ACIN1

Protein-coding gene in the species Homo sapiens
ACIN1
Identifiers
AliasesACIN1, ACINUS, ACN, fSAP152, apoptotic chromatin condensation inducer 1
External IDsOMIM: 604562; MGI: 1891824; HomoloGene: 22853; GeneCards: ACIN1; OMA:ACIN1 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for ACIN1
Genomic location for ACIN1
Band14q11.2Start23,058,564 bp[1]
End23,095,614 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for ACIN1
Genomic location for ACIN1
Band14|14 C2Start54,642,161 bp[2]
End54,686,931 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • right lobe of thyroid gland

  • sural nerve

  • left lobe of thyroid gland

  • right ovary

  • left ovary

  • body of uterus

  • canal of the cervix

  • right adrenal cortex

  • anterior pituitary
Top expressed in
  • neural layer of retina

  • tail of embryo

  • ventricular zone

  • genital tubercle

  • yolk sac

  • granulocyte

  • Rostral migratory stream

  • primary visual cortex

  • superior frontal gyrus

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ATPase activity
  • protein binding
  • enzyme binding
  • nucleic acid binding
  • RNA binding
Cellular component
  • nuclear speck
  • plasma membrane
  • exon-exon junction complex
  • nucleoplasm
  • nucleolus
  • ASAP complex
  • nucleus
  • cytosol
Biological process
  • apoptotic chromosome condensation
  • mRNA processing
  • negative regulation of mRNA splicing, via spliceosome
  • RNA splicing
  • positive regulation of apoptotic process
  • positive regulation of monocyte differentiation
  • erythrocyte differentiation
  • apoptotic process
  • execution phase of apoptosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22985

56215

Ensembl

ENSG00000100813

ENSMUSG00000022185

UniProt

Q9UKV3

Q9JIX8

RefSeq (mRNA)
NM_001164814
NM_001164815
NM_001164816
NM_001164817
NM_014977

NM_001386863

NM_001085472
NM_001085473
NM_001242605
NM_001242606
NM_019567

NM_023190

RefSeq (protein)

NP_001158286
NP_001158287
NP_001158288
NP_001158289
NP_055792

NP_001078941
NP_001078942
NP_001229534
NP_001229535
NP_062513

NP_075679
NP_001361699

Location (UCSC)Chr 14: 23.06 – 23.1 MbChr 14: 54.64 – 54.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Apoptotic chromatin condensation inducer in the nucleus is a protein that in humans is encoded by the ACIN1 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100813 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022185 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation". Nature. 401 (6749): 168–73. Bibcode:1999Natur.401..168S. doi:10.1038/43678. PMID 10490026. S2CID 4364282.
  7. ^ "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1".

External links

Further reading

  • Zermati Y, Garrido C, Amsellem S, et al. (2001). "Caspase activation is required for terminal erythroid differentiation". J. Exp. Med. 193 (2): 247–54. doi:10.1084/jem.193.2.247. PMC 2193347. PMID 11208865.
  • Sordet O, Rébé C, Plenchette S, et al. (2003). "Specific involvement of caspases in the differentiation of monocytes into macrophages". Blood. 100 (13): 4446–53. doi:10.1182/blood-2002-06-1778. PMID 12393560.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
  • Hu Y, Yao J, Liu Z, et al. (2005). "Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation". EMBO J. 24 (20): 3543–54. doi:10.1038/sj.emboj.7600823. PMC 1276706. PMID 16177823.
  • Joselin AP, Schulze-Osthoff K, Schwerk C (2006). "Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis". J. Biol. Chem. 281 (18): 12475–84. doi:10.1074/jbc.M509859200. PMID 16537548.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Shu Y, Iijima T, Sun W, et al. (2007). "The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma". Journal of Thoracic Oncology. 1 (2): 160–7. doi:10.1097/01243894-200602000-00010. PMID 17409846.


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