C8 complex
Protein involved in the complement system
Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).
A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.
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Structure
C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.
References
External links
- Complement+C8 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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- Cytotoxicity(by MAC)
- immune adherence
- Inducing inflammation
- Opsonization
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