CIDEB

Protein-coding gene in humans
CIDEB
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1D4B

Identifiers
AliasesCIDEB, cell death-inducing DFFA-like effector b, cell death inducing DFFA like effector b
External IDsOMIM: 604441; MGI: 1270844; HomoloGene: 7666; GeneCards: CIDEB; OMA:CIDEB - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for CIDEB
Genomic location for CIDEB
Band14q12Start24,305,096 bp[1]
End24,311,430 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for CIDEB
Genomic location for CIDEB
Band14|14 C3Start55,991,507 bp[2]
End55,995,915 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • duodenum

  • spleen

  • granulocyte

  • monocyte

  • blood

  • mucosa of esophagus

  • human kidney

  • left adrenal cortex

  • right adrenal gland
Top expressed in
  • right kidney

  • jejunum

  • human kidney

  • duodenum

  • left lobe of liver

  • ileum

  • proximal tubule

  • intestinal villus

  • epithelium of small intestine

  • colon
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • identical protein binding
Cellular component
  • perinuclear region of cytoplasm
  • cytosol
  • lipid droplet
  • intracellular anatomical structure
Biological process
  • positive regulation of release of cytochrome c from mitochondria
  • execution phase of apoptosis
  • activation of cysteine-type endopeptidase activity
  • positive regulation of cell death
  • intrinsic apoptotic signaling pathway in response to DNA damage
  • apoptotic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27141

12684

Ensembl

ENSG00000136305
ENSG00000285199

ENSMUSG00000022219

UniProt

Q9UHD4

O70303

RefSeq (mRNA)

NM_014430
NM_001318807

NM_009894
NM_026804

RefSeq (protein)

NP_001305736
NP_055245

NP_034024

Location (UCSC)Chr 14: 24.31 – 24.31 MbChr 14: 55.99 – 56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cell death-inducing DFFA-like effector b, also known as CIDEB, is a human gene.[5][6][7]

In humans, individuals carrying rare loss of function mutations in the CIDEB gene are protected against different aetiologies of liver disease.[8] CIDEB knockout mice have been generated by homolog recombination technique. The CIDE null mice show decreased lipogenesis. The CIDEB knockout mice are resistant to high fat diet induced obesity and liver steatosis. In addition, the CIDEB null mice also have improved insulin sensitivity and enhanced hepatic fatty acid oxidation and whole body metabolism.[9] CIDEB plays a key role in determining lipid droplet size: overexpression of CIDEB in vitro results in fat accumulation by inducing larger lipid droplets, while CIDEB knock-out experiments results in accumulation of smaller lipid droplets.[10][8]

References

  1. ^ a b c ENSG00000285199 GRCh38: Ensembl release 89: ENSG00000136305, ENSG00000285199 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022219 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CIDEB cell death-inducing DFFA-like effector b".
  6. ^ Ye J, Zhong Li J, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P (2009). "Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B." Cell Metabolism. 9 (2): 177–190. doi:10.1016/j.cmet.2008.12.013. PMID 19187774.
  7. ^ Li JZ, Lei Y, Wang Y, Zhang Y, Ye J, Xia X, Pan X, Li P (May 2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta. 1801 (5): 577–86. doi:10.1016/j.bbalip.2010.01.012. PMID 20123130.
  8. ^ a b Verweij N, Haas ME, Nielsen JB, Sosina OA, Kim M, Akbari P, De T, Hindy G, Bovijn J, Persaud T, Miloscio L, Germino M, Panagis L, Watanabe K, Mbatchou J (2022-07-28). "Germline Mutations in CIDEB and Protection against Liver Disease". New England Journal of Medicine. 387 (4): 332–344. doi:10.1056/NEJMoa2117872. ISSN 0028-4793. PMID 35939579. S2CID 251143047.
  9. ^ Zhong Li J, Ye J, Xue B, Qi J, Zhang J, Zhou Z, Li Q, Wen Z, Li P (2007). "Cideb regulates diet-induced obesity, liver steatosis and insulin sensitivity by controlling lipogeneis and fatty acid oxidation". Diabetes. 56 (10): 2523–2532. doi:10.2337/db07-0040. PMID 17646209.
  10. ^ Xu W, Wu L, Yu M, Chen FJ, Arshad M, Xia X, Ren H, Yu J, Xu L, Xu D, Li JZ, Li P, Zhou L (2016-02-26). "Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes". The Journal of Biological Chemistry. 291 (9): 4282–4293. doi:10.1074/jbc.M115.701094. ISSN 1083-351X. PMC 4813457. PMID 26733203.

Further reading

  • Inohara N, Koseki T, Chen S, et al. (1998). "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor". EMBO J. 17 (9): 2526–33. doi:10.1093/emboj/17.9.2526. PMC 1170594. PMID 9564035.
  • Lugovskoy AA, Zhou P, Chou JJ, et al. (2000). "Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis". Cell. 99 (7): 747–55. doi:10.1016/S0092-8674(00)81672-4. PMID 10619428.
  • Chen Z, Guo K, Toh SY, et al. (2000). "Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis". J. Biol. Chem. 275 (30): 22619–22. doi:10.1074/jbc.C000207200. PMID 10837461.
  • Liang L, Zhao M, Xu Z, et al. (2003). "Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family". Biochem. J. 370 (Pt 1): 195–203. doi:10.1042/BJ20020656. PMC 1223158. PMID 12429024.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Erdtmann L, Franck N, Lerat H, et al. (2003). "The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis" (PDF). J. Biol. Chem. 278 (20): 18256–64. doi:10.1074/jbc.M209732200. PMID 12595532.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Da L, Li D, Yokoyama KK, et al. (2006). "Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene". Biochem. J. 393 (Pt 3): 779–88. doi:10.1042/BJ20051027. PMC 1360731. PMID 16248853.
  • Li JZ, Lei Y, Wang Y, Zhang Y, Ye J, Xia X, Pan X, Li P, et al. (2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta. 1801 (Pt 5): 577–586. doi:10.1016/j.bbalip.2010.01.012. PMID 20123130.



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