CRIP2

Protein-coding gene in the species Homo sapiens
CRIP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CU8

Identifiers
AliasesCRIP2, CRIP, CRP2, ESP1, cysteine rich protein 2
External IDsOMIM: 601183; MGI: 1915587; HomoloGene: 135666; GeneCards: CRIP2; OMA:CRIP2 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for CRIP2
Genomic location for CRIP2
Band14q32.33Start105,472,962 bp[1]
End105,480,162 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for CRIP2
Genomic location for CRIP2
Band12 F1|12 61.57 cMStart113,103,856 bp[2]
End113,109,126 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • right auricle

  • right coronary artery

  • popliteal artery

  • tibial arteries

  • Descending thoracic aorta

  • ascending aorta

  • left coronary artery

  • right uterine tube

  • left ventricle
Top expressed in
  • ankle joint

  • right ventricle

  • right lung

  • right lung lobe

  • left lung

  • gastrula

  • interventricular septum

  • endothelial cell of lymphatic vessel

  • lip

  • atrium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • zinc ion binding
  • protein binding
Cellular component
  • cell cortex
Biological process
  • positive regulation of cell population proliferation
  • hemopoiesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1397

68337

Ensembl

ENSG00000182809

ENSMUSG00000006356

UniProt

P52943

Q9DCT8

RefSeq (mRNA)

NM_001270837
NM_001270841
NM_001312

NM_024223
NM_001347443

RefSeq (protein)

NP_001257766
NP_001257770
NP_001303

NP_001334372
NP_077185

Location (UCSC)Chr 14: 105.47 – 105.48 MbChr 12: 113.1 – 113.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cysteine-rich protein 2 is a protein that in humans is encoded by the CRIP2 gene.[5][6][7][8]

CRIP2 and the closely related CRIP1 are cysteine-rich proteins containing two LIM domains. They are highly expressed during cardiovascular development and act to bridge serum response factor and GATA proteins and stimulate smooth muscle target genes.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182809 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006356 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tsui SK, Chan PP, Cheuk CW, Liew CC, Waye MM, Fung KP, Lee CY (Feb 1997). "A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation". Biochem Mol Biol Int. 39 (4): 747–54. doi:10.1080/15216549600201831. PMID 8843343. S2CID 25981657.
  6. ^ Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y (January 1996). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.
  7. ^ Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD (Mar 2000). "Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle". J Biol Chem. 275 (8): 5504–11. doi:10.1074/jbc.275.8.5504. PMID 10681529.
  8. ^ "Entrez Gene: CRIP2 cysteine-rich protein 2".
  9. ^ Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (January 2003). "Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors". Dev. Cell. 4 (1): 107–18. doi:10.1016/S1534-5807(02)00396-9. PMID 12530967.

External links

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • van Ham M, Croes H, Schepens J, et al. (2004). "Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL". Genes Cells. 8 (7): 631–44. doi:10.1046/j.1365-2443.2003.00660.x. PMID 12839623.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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  • 2cu8: Solution structure of the LIM domain of human Cysteine-rich protein 2
    2cu8: Solution structure of the LIM domain of human Cysteine-rich protein 2


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