CYP20A1

Protein-coding gene in the species Homo sapiens

CYP20A1

Identifiers

Aliases

CYP20A1, CYP-M, cytochrome P450 family 20 subfamily A member 1

External IDs

MGI: 1925201 HomoloGene: 18584 GeneCards: CYP20A1

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q33.2	Start	203,238,940 bp^[1]
Band	2q33.2	End	203,305,611 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 C2	Start	60,382,482 bp^[2]
Band	1\|1 C2	End	60,427,219 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

monocyte

islet of Langerhans

body of pancreas

rectum

left adrenal gland

gallbladder

stromal cell of endometrium

left coronary artery

sural nerve

Top expressed in

belly cord

seminal vesicula

calvaria

ureter

cumulus cell

renal corpuscle

left lung lobe

dermis

trigeminal ganglion

interventricular septum

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


57404


77951

Ensembl


ENSG00000119004


ENSMUSG00000049439

UniProt


Q6UW02


Q8BKE6

RefSeq (mRNA)


NM_020674 NM_177538


NM_030013 NM_001313721

RefSeq (protein)

NP_803882 NP_001358624 NP_001358625 NP_001358626 NP_001358627
NP_001358628 NP_001358629 NP_001358630 NP_001358631 NP_001358632 NP_001358633 NP_001358634 NP_001358635


NP_001300650 NP_084289

Location (UCSC)

Chr 2: 203.24 – 203.31 Mb

Chr 1: 60.38 – 60.43 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1) is a protein which in humans is encoded by the CYP20A1 gene.^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in pollutant and drug metabolism and the synthesis of cholesterol, steroids, and other lipids. CYP20A1 lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen.^[6]

CYP20A1 has no identified substrate or biological role and is considered an "orphan" P450.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119004 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049439 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
^ This article incorporates public domain material from "Entrez Gene: CY20A1". Reference Sequence collection. National Center for Biotechnology Information.

External links

Human CYP20A1 genome location and CYP20A1 gene details page in the UCSC Genome Browser.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jiang JH, Jia WH, Qin HD, et al. (2004). "[Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue]". AI Zheng. 23 (6): 672–7. PMID 15191668.
Werck-Reichhart D, Feyereisen R (2000). "Cytochromes P450: a success story". Genome Biol. 1 (6): REVIEWS3003. doi:10.1186/gb-2000-1-6-reviews3003. PMC 138896. PMID 11178272.
Ross CJ, Katzov-Eckert H, Dubé MP, et al. (2009). "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy". Nat. Genet. 41 (12): 1345–9. doi:10.1038/ng.478. PMID 19898482. S2CID 21293339.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.