DGLUCY

DGLUCY
Identifiers
Aliases	DGLUCY, C14orf159, chromosome 14 open reading frame 159, D-glutamate cyclase
External IDs	MGI: 2444813; HomoloGene: 11798; GeneCards: DGLUCY; OMA:DGLUCY - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.11 Start 91,060,333 bp[1] End 91,225,632 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 100,745,316 bp[2] End 100,863,240 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left ventricle right auricle muscle of thigh triceps brachii muscle gastrocnemius muscle body of tongue body of stomach fundus granulocyte Top expressed in right kidney interventricular septum human kidney lacrimal gland proximal tubule granulocyte duodenum muscle of thigh left lobe of liver right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding D-glutamate cyclase activity lyase activity molecular function Cellular component mitochondrion mitochondrial matrix cellular component Biological process glutamate metabolic process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80017 217830 Ensembl ENSG00000133943 ENSMUSG00000021185 UniProt Q7Z3D6 Q8BH86 RefSeq (mRNA) NM_024952 NM_001102366 NM_001102367 NM_001102368 NM_001102369 NM_001286470 NM_001286471 NM_001286472 NM_001286473 NM_001358310 NM_001358311 NM_001358312 NM_145448 NM_001361017 NM_001361020 NM_001361023 RefSeq (protein) NP_001095836 NP_001095837 NP_001095838 NP_001095839 NP_001273399 NP_001273400 NP_001273401 NP_001273402 NP_079228 NP_001345239 NP_001345240 NP_001345241 NP_663423 NP_001347946 NP_001347949 NP_001347952 Location (UCSC) Chr 14: 91.06 – 91.23 Mb Chr 12: 100.75 – 100.86 Mb PubMed search [3] [4]
Wikidata
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DGLUCY (D-glutamate cyclase) is a protein that in humans is encoded by the DGLUCY gene.^[5]

Orthologs

The human gene, DGLUCY, is highly conserved in mammals and birds.^[6] Orthologs gathered from BLAST and BLAT searches reveal that the human DGLUCY mRNA sequence is conserved with a sequence identity of 98% in chimpanzees, 88% in mice, and 81% in platypus and chicken.^[7][8] The following table contains a list orthologs that were gathered from BLAST searches. Sequence alignments were performed using blastn to derive sequence identity, score, and E-values between the human c14orf159 variant 1 mRNA and its orthologs.

The protein that the human gene DGLUCY encodes has been found to be highly conserved among mammals, birds, amphibians, fish, tunicates, cnidarians, and echinoderms. However, no protein orthologs have been found in nematodes, arthropods, fungi, protists, plants, bacteria, or archea. Fungi and bacteria contain the DUF1445 conserved domain which is found in human c14orf159 and its orthologs. BLAST and BLAT searches have been utilized to find orthologs to the c14orf159 protein. The following table lists protein orthologs for the human protein with sequence identity, sequence similarity, scores, and E-values derived from blastp sequence comparisons.^[9]

Post-translational modification

The protein product of the DGLUCY gene is predicted^[5] and was found^[10][11] to be translocated to mitochondrion.

Post-translational modifications are predicted for the protein DGLUCY. All predicted sites in human DGLUCY were compared to orthologs using multiple sequence alignments to determine likelihood of modification.^{[12][13][14][15] [16]}

Regulation

Estrogen receptor alpha, in the presence of estradiol, binds to the DGLUCY gene and likely regulates its expression.^[17]

References

External links

• Human C14orf159 genome location and C14orf159 gene details page in the UCSC Genome Browser.

Further reading