EPH receptor B2

EPHB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B4F, 1F0M, 2QBX, 3ZFM
Identifiers
Aliases	EPHB2, Ephb2, Cek5, Drt, ETECK, Erk, Hek5, Nuk, Prkm5, Qek5, Sek3, Tyro5, CAPB, EK5, EPHT3, PCBC, EPH receptor B2, DRT, ERK, BDPLT22
External IDs	OMIM: 600997 MGI: 99611 HomoloGene: 37925 GeneCards: EPHB2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 22,710,839 bp[1] End 22,921,500 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 69.0 cM Start 136,374,850 bp[2] End 136,563,299 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence rectum duodenum islet of Langerhans cecum appendix pericardium periodontal fiber human penis prefrontal cortex Top expressed in internal carotid artery crypt of lieberkuhn of small intestine external carotid artery Paneth cell ganglionic eminence maxillary prominence abdominal wall medial ganglionic eminence vas deferens left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity transmembrane-ephrin receptor activity kinase activity protein binding identical protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity signaling receptor binding ATP binding axon guidance receptor activity ephrin receptor activity amyloid-beta binding signaling receptor activity protein-containing complex binding Cellular component integral component of membrane cytosol cell projection membrane integral component of plasma membrane extracellular region axon neuronal cell body dendrite nucleus plasma membrane neuron projection receptor complex postsynapse glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane Biological process positive regulation of synapse assembly roof of mouth development phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway optic nerve morphogenesis ephrin receptor signaling pathway learning commissural neuron axon guidance nervous system development multicellular organism development regulation of axonogenesis dendritic spine development dendritic spine morphogenesis negative regulation of axonogenesis protein phosphorylation positive regulation of long-term neuronal synaptic plasticity regulation of body fluid levels inner ear morphogenesis angiogenesis cell morphogenesis animal organ morphogenesis regulation of neuronal synaptic plasticity urogenital system development peptidyl-tyrosine phosphorylation corpus callosum development central nervous system projection neuron axonogenesis axonal fasciculation camera-type eye morphogenesis retinal ganglion cell axon guidance axon guidance trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission negative regulation of protein phosphorylation learning or memory positive regulation of gene expression positive regulation of synaptic plasticity negative regulation of Ras protein signal transduction regulation of synapse assembly negative regulation of ERK1 and ERK2 cascade postsynaptic membrane assembly neuron projection retraction positive regulation of long-term synaptic potentiation positive regulation of protein localization to plasma membrane negative regulation of NMDA glutamate receptor activity positive regulation of NMDA glutamate receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2048 13844 Ensembl ENSG00000133216 ENSMUSG00000028664 UniProt P29323 P54763 RefSeq (mRNA) NM_001309192 NM_001309193 NM_004442 NM_017449 NM_001290753 NM_010142 RefSeq (protein) NP_001296121 NP_001296122 NP_004433 NP_059145 NP_001277682 NP_034272 Location (UCSC) Chr 1: 22.71 – 22.92 Mb Chr 4: 136.37 – 136.56 Mb PubMed search [3] [4]
Wikidata
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Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene.^[5]

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.^[6]

Animal studies

EphB2 is part of the NMDA signaling pathway and restoring expression rescues cognitive function in an animal model of Alzheimer's disease.^[7]

A recessive EphB2 gene is responsible for the crested-feather mutation in pigeons.^[8]

Interactions

EPH receptor B2 has been shown to interact with:

• Abl gene^[9]
• RAS p21 protein activator 1^[10]
• Src^[11][12]

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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