Ferroxidase

Iron oxidizing enzyme, Fe(II) to Fe(III) conversion

Ferroxidase

Identifiers

EC no.

1.16.3.1

CAS no.

9031-37-2

Databases

IntEnz

IntEnz view

BRENDA

BRENDA entry

ExPASy

NiceZyme view

KEGG

KEGG entry

MetaCyc

metabolic pathway

PRIAM

profile

PDB structures

RCSB PDB PDBe PDBsum

Gene Ontology

AmiGO / QuickGO

Ferroxidase also known as Fe(II):oxygen oxidoreductase is an enzyme that catalyzes the oxidization of iron II to iron III:

4 Fe²⁺ + 4 H⁺ + O₂ ⇔ 4 Fe³⁺ + 2H₂O

Examples

Human genes encoding proteins with ferroxidase activity include:

Cox JC, Boxer DH (1986). "The role of rusticyanin, a blue copper protein, in the electron transport chain of Thiobacillus ferrooxidans grown on iron or thiosulfate". Biotechnol. Appl. Biochem. 8: 269–275.
Osaki S (November 1966). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)". J. Biol. Chem. 241 (21): 5053–9. doi:10.1016/S0021-9258(18)99669-9. PMID 5925868.
Osaki S, Walaas O (June 1967). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase. II. Rate constants at various steps and formation of a possible enzyme-substrate complex". J. Biol. Chem. 242 (11): 2653–7. doi:10.1016/S0021-9258(18)99620-1. PMID 6027241.

Other oxidoreductases (EC 1.15–1.21)

1.15: Acting on superoxide as acceptor

1.16: Oxidizing metal ions

1.17: Acting on CH or CH2 groups

1.18: Acting on iron–sulfur proteins as donors

1.19: Acting on reduced flavodoxin as donor

1.20: Acting on phosphorus or arsenic in donors

1.21: Acting on X-H and Y-H to form an X-Y bond

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)