GDF7

Protein-coding gene in the species Homo sapiens
GDF7
Identifiers
AliasesGDF7, BMP12, growth differentiation factor 7
External IDsOMIM: 604651; MGI: 95690; HomoloGene: 32177; GeneCards: GDF7; OMA:GDF7 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for GDF7
Genomic location for GDF7
Band2p24.1Start20,667,144 bp[1]
End20,679,243 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for GDF7
Genomic location for GDF7
Band12|12 A1.1Start8,347,918 bp[2]
End8,351,954 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • seminal vesicula

  • endometrium

  • ascending aorta

  • right coronary artery

  • canal of the cervix

  • kidney tubule

  • popliteal artery

  • vagina

  • right lobe of liver

  • myometrium
Top expressed in
  • uterus

  • foot

  • shoulder

  • toe

  • rhombencephalon

  • cerebellar cortex

  • mesencephalon

  • thymus

  • diencephalon

  • heart
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cytokine activity
  • protein homodimerization activity
  • protein binding
  • transforming growth factor beta receptor binding
  • growth factor activity
Cellular component
  • extracellular region
  • extracellular space
Biological process
  • regulation of apoptotic process
  • pathway-restricted SMAD protein phosphorylation
  • cell fate commitment
  • epithelial cell differentiation
  • regulation of MAPK cascade
  • SMAD protein signal transduction
  • spinal cord association neuron differentiation
  • cell development
  • positive regulation of tendon cell differentiation
  • positive regulation of pathway-restricted SMAD protein phosphorylation
  • roof plate formation
  • BMP signaling pathway
  • axon guidance
  • reproductive structure development
  • positive regulation of transcription, DNA-templated
  • forebrain morphogenesis
  • gland morphogenesis
  • positive regulation of gene expression
  • positive regulation of neuron differentiation
  • neural tube development
  • branching morphogenesis of an epithelial tube
  • midbrain development
  • activin receptor signaling pathway
  • morphogenesis of an epithelial fold
  • regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

151449

238057

Ensembl

ENSG00000143869

ENSMUSG00000037660

UniProt

Q7Z4P5

P43029

RefSeq (mRNA)

NM_182828

NM_013527
NM_001312876

RefSeq (protein)

NP_878248

NP_001299805
NP_038555

Location (UCSC)Chr 2: 20.67 – 20.68 MbChr 12: 8.35 – 8.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene.[5]

GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos. The roof plate is required for the generation of several classes of spinal cord dorsal interneurons; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cells by generating signals within the roof plate.[5][6]

GDF7 is also known as bone morphogenic protein 12 (BMP-12).[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143869 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037660 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Lee KJ, Mendelsohn M, Jessell TM (November 1998). "Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord". Genes Dev. 12 (21): 3394–407. doi:10.1101/gad.12.21.3394. PMC 317230. PMID 9808626.
  6. ^ Lo L, Dormand E, Anderson D (2005). "Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7". Proc Natl Acad Sci USA. 102 (20): 7192–7. Bibcode:2005PNAS..102.7192L. doi:10.1073/pnas.0502581102. PMC 1091754. PMID 15883363.
  7. ^ Peng C, Lei C, Guofei C, Tian Y, Wei L, Jianwei Z, Chen W, Wentao Z, Changqing J (2019). "The application of BMP-12-overexpressing mesenchymal stem cells loaded 3D-printed PLGA scaffolds in rabbit rotator cuff repair". International Journal of Biological Macromolecules. 138: 79–88. doi:10.1016/j.ijbiomac.2019.07.041. PMID 31295489. S2CID 195892657.

Further reading

  • Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
  • Davidson AJ, Postlethwait JH, Yan YL, et al. (1999). "Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily". Genome Res. 9 (2): 121–9. doi:10.1101/gr.9.2.121. PMID 10022976.
  • Butler SJ, Dodd J (2003). "A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons". Neuron. 38 (3): 389–401. doi:10.1016/S0896-6273(03)00254-X. PMID 12741987. S2CID 6434429.
  • Mazerbourg S, Sangkuhl K, Luo CW, et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014. S2CID 23693180.
  • v
  • t
  • e
TGF beta superfamily of ligands
Ligand of ACVR or TGFBR
Ligand of BMPR
TGF beta receptors
(Activin, BMP, family)
TGFBR1:
TGFBR2:
TGFBR3:
Transducers/SMADLigand inhibitors
CoreceptorsOther
  • v
  • t
  • e
TGFβ receptor superfamily modulators
Type I
ALK1 (ACVRL1)
  • Kinase inhibitors: K-02288
  • ML-347 (LDN-193719, VU0469381)
  • Other inhibitors: Disitertide
ALK2 (ACVR1A)
  • Kinase inhibitors: DMH-1
  • DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
  • ML-347 (LDN-193719, VU0469381)
ALK3 (BMPR1A)
  • Kinase inhibitors: DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
ALK4 (ACVR1B)
  • Kinase inhibitors: A 83-01
  • SB-431542
  • SB-505124
ALK5 (TGFβR1)
ALK6 (BMPR1B)
  • Kinase inhibitors: DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
ALK7 (ACVR1C)
  • Antagonists: Lefty (1, 2)
  • Kinase inhibitors: A 83-01
  • SB-431542
  • SB-505124
Type II
TGFβR2
  • Kinase inhibitors: DMH-2
  • LY-364947
BMPR2
ACVR2A (ACVR2)
ACVR2B
  • Decoy receptors: Ramatercept
AMHR2 (AMHR)
Type III
TGFβR3 (β-glycan)
Unsorted


Stub icon

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e