| Title | Author | Japanese publisher | English publisher |
| S.A (S・A(スペシャル・エー), S.A (Supesharu Ē)) | Maki Minami | Hakusensha | Viz Media |
| S.S. Astro (教艦ASTRO, Kyōkan Asutoro) | Negi Banno | Houbunsha | Yen Press |
| Saber Marionette J (セイバーマリオネット J, Seibā Marionetto Jei) | Satoru Akahori and Yumisuke Kotoyoshi | Kadokawa Shoten | Tokyopop (NA)
Madman Entertainment (ANZ) |
| Saikano (最終兵器彼女, Saishū Heiki Kanojo) | Shin Takahashi | Shogakukan | Viz Media |
| Sailor Moon (美少女戦士セーラームーン, Bishōjo Senshi Sērā Mūn) | Naoko Takeuchi | Kodansha | Tokyopop (formerly)
Kodansha USA |
| Saint Seiya (聖闘士星矢, Seinto Seiya) | Masami Kurumada | Shueisha | Viz Media |
| Saint Tail (怪盗セイント・テール, Kaitō Seinto Tēru) | Megumi Tachikawa | Kodansha | Tokyopop |
Saiyuki (幻想魔伝 最遊記, Gensō Maden Saiyūki)
| Kazuya Minekura | Enix (Saiyuki)
Issaisha (Saiyuki Reload) | Tokyopop (NA)
Chuang Yi (SG) |
| Sakura Taisen (サクラ大戦 漫画版, Sakura Taisen Manga-ban) | Ouji Hiroi, Satoru Akahori, and Ikku Masa | Kodansha | Tokyopop |
| Samurai Champloo (サムライチャンプルー, Samurai Chanpurū) | Shinichirō Watanabe and Masaru Gotsubo | Kadokawa Shoten | Bandai Entertainment |
| Samurai Deeper Kyo (サムライ ディーパー キョウ, Samurai Dīpā Kyō) | Akimine Kamijyo | Kodansha | Tokyopop |
| Samurai Executioner (首斬り朝, Kubikiri Asa) | Kazuo Koike and Goseki Kojima | Kodansha | Dark Horse Comics |
| Real Bout High School (SAMURAI GIRL リアルバウトハイスクール, Samurai Gāru: Riaru Bauto Hai Sukūru) | Reiji Saiga and Sora Inoue | Fujimi Shobo | Tokyopop |
| Samurai Harem: Asu no Yoichi (明日のよいち!, Asu no Yoichi!) | Yū Minamoto | Akita Shoten | Tokyopop |
| Sanctuary (サンクチュアリ, Sankuchuari) | Buronson and Ryoichi Ikegami | Shogakukan | Viz Media |
| Sand Chronicles (砂時計, Suna-dokei) | Hinako Ashihara | Shogakukan | Viz Media |
| Sand Land (サンドランド, Sando Rando) | Akira Toriyama | Shueisha | Viz Media |
| Satisfaction Guaranteed (よろず屋東海道本舗, Yorozuya Tōkaidō Honpo) | Ryo Saenagi | Hakusensha | Tokyopop |
| Sayonara, Zetsubou-Sensei (さよなら 絶望先生, Sayonara Zetsubō Sensei) | Kōji Kumeta | Kodansha | Kodansha USA |
| Saving Life | Mario Kaneda | Kadokawa | Tokyopop (previous)
Viz Media (subsequent)[11] |
| School Rumble (スクールランブル, Sukūru Ranburu) | Jin Kobayashi | Kodansha | Del Rey Manga (NA)
Tanoshimi (UK) |
| School Zone (スクールゾーン, Sukūru Zōn) | Kanako Inuki | Leed Publishing | Dark Horse Comics |
| Scrapped Princess (スクラップド・プリンセス, Sukurappudo Purinsesu) | Ichiro Sakaki and Yabuki Go | Kadokawa Shoten | Tokyopop |
| Scryed (スクライド, Sukuraido) | Yōsuke Kuroda and Yasunari Toda | Akita Shoten | Tokyopop |
| Seduce Me After the Show | est em | Tokyo Mangasha | Aurora Publishing |
| Seikai Trilogy (星界の紋章, Seikai no Monshō) | Aya Yoshinaga | | Tokyopop |
| Selfish Love (君主サマの恋は勝手, Kunshu-sama no Koi wa Katte!) | Naduki Koujima | Biblos | Central Park Media |
| Sensual Phrase (快感フレーズ, Kaikan Furēzu) | Mayu Shinjo | Shogakukan | Viz Media |
| Seraph of the End (終わりのセラフ, Owari no Serafu) | Takaya Kagami and Yamato Yamamoto | Shueisha | Viz Media |
| The Seven Deadly Sins (七つの大罪, Nanatsu no Taizai) | Nakaba Suzuki | Kodansha | Kodansha USA |
| Seven of Seven (七人のナナ, Shichinin no Nana) | Yasuhiro Imagawa and Azusa Kunihiro | Akita Shoten | ADV Manga |
| Sexy Voice and Robo (セクシーボイスアンドロボ, Sekushī Boisu ando Robo) | Iou Kuroda | Shogakukan | Viz Media |
| Sgt. Frog (ケロロ軍曹, Keroro Gunsō) | Mine Yoshizaki | Kadokawa Shoten | Tokyopop |
| Shadow Lady (シャドウレディ, Shadō Redi) | Masakazu Katsura | Shueisha | Dark Horse Comics |
| Shadow Star (なるたる, Narutaru) | Mohiro Kitoh | Kodansha | Dark Horse Comics |
| Shakugan no Shana (灼眼のシャナ, Shakugan no Shana) | Yashichiro Takahashi and Ayato Sasakura | MediaWorks | Viz Media |
| Shaman King (シャーマンキング, Shāman Kingu) | Hiroyuki Takei | Shueisha (former)
Kodansha (current) | Viz Media (former)
Kodansha USA (current) |
| Shiki Tsukai (四季使い, Shiki Tsukai) | To-Ru Zekuu and Yuna Takanagi | Kodansha | Del Rey Manga |
| Shinobi Life (シノビライフ, Shinobi Raifu) | Shoko Conami | Akita Shoten | Tokyopop |
| Shirahime-Syo: Snow Goddess Tales (白姫抄, Shiro Hime Shō) | Clamp | Kobunsha (1992)
Kadokawa Shoten (2001) | Tokyopop |
| Short Program (ショートプログラム, Shōto Puroguramu) | Mitsuru Adachi | Shogakukan | Viz Media |
| Short Cuts (ショートカッツ, Shōto Kattsu) | Usamaru Furuya | Shogakukan | Viz Media |
| Shout Out Loud! (叫んでやるぜ!, Yonde Yaru ze!) | Satosumi Takaguchi | Kadokawa Shoten | Blu |
| Shugo Chara! (しゅごキャラ!, Shugo Kyara!) | Peach-Pit | Kodansha | Kodansha USA |
| Silent Möbius (サイレントメビウス, Sairento Mebiusu) | Kia Asamiya | Kadokawa Shoten | Viz Media |
| A Silent Voice (聲の形, Koe no Katachi) | Yoshitoki Ōima | Kodansha | Kodansha USA (NA) |
| Since You've Been Gone: see Four Shōjo Stories |
| Skip Beat! (スキップ・ビート!, Sukippu Bīto!) | Yoshiki Nakamura | Hakusensha | Viz Media |
| Skull Man (スカルマン, Sukaru Man) | Kazuhiko Shimamoto | Media Factory | Tokyopop |
| Skyscrapers of Oz (オズの摩天楼, Ozu no Matenrō) | Yoshino Somei and Row Takamura | Chara Comics | Media Blasters |
| Slam Dunk (スラムダンク, Suramu Danku) | Takehiko Inoue | Shueisha | Viz Media |
| Slayers (スレイヤーズ, Sureiyāzu) | Rui Araizumi, Issei Hyouji, Hajime Kanzaka, Yoshijirou Muramatsu, Tommy Ohtsuka, Shin Sasaki, and Shoko Yoshinaka | Kadokawa Shoten | Central Park Media |
| Slut Girl (スラッと女, Suratto Onna) | Isutoshi | Fujimi Publishing | Eros Comix |
| Socrates in Love (世界の中心で、愛をさけぶ, Sekai no Chūshin de Ai o Sakebu) | Kyoichi Katayama and Kazumi Kazui | Shogakukan | Viz Media |
| Solanin (ソラニン, Soranin) | Inio Asano | Shogakukan | Viz Media |
| Solfege (ソルフェージュ, Sorufēju) | Fumi Yoshinaga | Hakusensha, Houbunsha | Digital Manga Publishing |
| Someday's Dreamers (魔法遣いに大切なこと, Mahō Tsukai ni Taisetsu na Koto) (and Someday's Dreamers: Spellbound sequel) | Norie Yamada and Kumichi Yoshizuki | Kadokawa Shoten | Tokyopop |
| Sorcerer Hunters (爆れつハンター, Bakuretsu Hantā) | Satoru Akahori and Ray Omishi | MediaWorks | Tokyopop |
| Soul Eater (ソウルイーター, Sōru Ītā) | Atsushi Okubo | Gangan Comics | Yen Press
Square Enix (Perfect Edition) |
| Soul Eater Not! (ソウルイーターノット!, Sōru Ītā Notto!) | Atsushi Okubo | Gangan Comics | Yen Press |
| Soul Rescue (ソウルレスキュー, Sōru Resukyū) | Aya Kanno | Hakusensha | Tokyopop |
| Spider-Man: The Manga (スパイダーマン, Supaidāman) | Ryoichi Ikegami and Kazumasa Hirai | Kodansha | Marvel Comics |
| Spiral: The Bonds of Reasoning (スパイラル〜推理の絆〜, Supairaru - Suiri no Kizuna) | Kyou Shirodaira and Eita Mizuno | Gangan Comics | Tokyopop (former)
Yen Press (current) |
| Spirit of Wonder (スピリット オブ ワンダー, Supiritto Obu Wandā) | Kenji Tsuruta | Kodansha | Dark Horse Comics |
| Spy × Family (SPY×FAMILY) | Tatsuya Endo | Shueisha | Viz Media |
| Spring Fever (水温む, Mizu Nurumu) | Yugi Yamada | Houbunsha | Aurora Publishing |
| Star Wars series (スター・ウォーズ, Sutā Wōzu) | Kia Asamiya (The Phantom Menace)
Hisao Tamaki (A New Hope)
Toshiki Kudo (The Empire Strikes Back)
Sin-Ichi Hiromoto (Return of the Jedi) | MediaWorks | Dark Horse Comics |
| Steam Detectives (快傑蒸気探偵団, Kaiketsu Jōki Tanteidan) | Kia Asamiya | Shueisha | Viz Media |
| Steel Angel Kurumi (鋼鉄天使くるみ, Kōtetsu Tenshi Kurumi) | Kaishaku | Kadokawa Shoten | ADV Manga |
| Stellvia (宇宙のステルヴィア, Uchū no Suterubia) | Ryou Akizuki | MediaWorks | DrMaster |
| Strain (ストライン, Sutorain) | Buronson and Ryoichi Ikegami | Shogakukan | Viz Media |
| A Strange and Mystifying Story (この世異聞, Kono Yo Ibun) | Tsuta Suzuki | Libre Publishing | Digital Manga Publishing |
| Strawberry 100% (いちご100%, Ichigo 100%) | Mizuki Kawashita | Shueisha | Viz Media |
| Strawberry Marshmallow (苺ましまろ, Ichigo Mashimaro) | Barasui | MediaWorks | Tokyopop |
| Strawberry Panic! (ストロベリー・パニック!, Sutoroberī Panikku!) | Sakurako Kimino and Namuchi Takumi | MediaWorks | Seven Seas Entertainment |
| Street Fighter II (ストリートファイターII RYU, Sutorīto Faitā Ryū) | Masaomi Kanzaki | Tokuma Shoten | Tokuma Comics (1994)
UDON Entertainment (2007) |
| Striker or Spriggan (スプリガン, Supurigan)[n 19] | Hiroshi Takashige and Ryōji Minagawa | Shogakukan | Viz Media (NA)
Chuang Yi (SG) |
| Sugar Princess (シュガープリンセス, Shugā Purinsesu) | Hisaya Nakajo | Hakusensha | Viz Media |
| Sugar Sugar Rune (シュガシュガルーン, Shuga Shuga Rūn) | Moyoco Anno | Kodansha | Del Rey Manga |
| Suikoden III (幻想水滸伝 III, Gensō Suikoden Surī) | Aki Shimizu | | Tokyopop |
| Suki: A Like Story (すき。だからすき, Suki. Dakara Suki) | Clamp | Kadokawa Shoten | Tokyopop |
| Sumomomo Momomo: The Strongest Bride on Earth (すもももももも〜地上最強のヨメ〜, Sumomo mo Momo mo ~Chijō Saikyō no Yome~) | Shinobu Ohtaka | Square Enix | Yen Press |
| The Super Dimension Fortress Macross II: Lovers, Again (超時空要塞マクロスII -LOVERS AGAIN-, Chō-jikū Yōsai Makurosu Tsū: Rabāzu Agein) | Sukehiro Tomita and Tsuguo Okazaki | Shogakukan | Viz Media |
| Super Taboo (SUPERファミリーコンプレックス, Sūpā Famirī Konpurekkusu) | Wolf Ogami | Fujimi Publishing | Eros Comix |
| Suzuka (涼風, Suzuka) | Kouji Seo | Kodansha | Del Rey Manga |
| Swallowing the Earth (地球を呑む, Chikyū o Nomu) | Osamu Tezuka | Shogakukan | Digital Manga |
| Swan (SWAN, Suwan) | Kyoko Ariyoshi | Shueisha | CMX Manga |
| Sweet Rein (よろしく・マスター, Yoroshiku Masutā) | Sakura Tsukuba | Hakusensha | Viz Media |
| Switch (スイッチ, Suicchi) | Otoh Saki | Square Enix | Viz Media |
| Sword of the Dark Ones (RAGNRAROK, Ragunaroku) | Kentaro Yasui and Tsukasa Kotobuki | Kadokawa Shoten | CMX Manga |
| The Sword of Shibito (しびとの剣, Shibito no Ken) | Hideyuki Kikuchi and Missile Kakurai | Gentosha | CPM Manga |
