MT1B

Protein-coding gene in the species Homo sapiens
MT1B
Identifiers
AliasesMT1B, MT1, MT1Q, MTP, metallothionein 1B, MT-IB, MT-1B
External IDsOMIM: 156349; HomoloGene: 48385; GeneCards: MT1B; OMA:MT1B - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for MT1B
Genomic location for MT1B
Band16q13Start56,651,886 bp[1]
End56,653,204 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • duodenum

  • appendix

  • mucosa of esophagus

  • left uterine tube

  • urinary bladder

  • human musculoskeletal system

  • skeletal striated muscle

  • islet of Langerhans

  • muscle of leg
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • zinc ion binding
  • metal ion binding
Cellular component
  • cytoplasm
  • perinuclear region of cytoplasm
  • nucleus
Biological process
  • negative regulation of growth
  • cellular response to zinc ion
  • cellular zinc ion homeostasis
  • detoxification of copper ion
  • cellular response to cadmium ion
  • cellular response to copper ion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4490

n/a

Ensembl

ENSG00000169688

n/a

UniProt

P07438

n/a

RefSeq (mRNA)

NM_005947

n/a

RefSeq (protein)

NP_005938

n/a

Location (UCSC)Chr 16: 56.65 – 56.65 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Metallothionein-1B is a protein that in humans is encoded by the MT1B gene.[3][4][5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169688 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A. 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi:10.1073/pnas.81.17.5494. PMC 391732. PMID 6089206.
  4. ^ Heguy A, West A, Richards RI, Karin M (Dec 1986). "Structure and tissue-specific expression of the human metallothionein IB gene". Mol Cell Biol. 6 (6): 2149–57. doi:10.1128/MCB.6.6.2149. PMC 367755. PMID 3785191.
  5. ^ "Entrez Gene: MT1B metallothionein 1B".

Further reading

  • Lederer CW, Torrisi A, Pantelidou M, et al. (2007). "Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis". BMC Genomics. 8: 26. doi:10.1186/1471-2164-8-26. PMC 1796866. PMID 17244347.
  • Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID 15747776. S2CID 14394243.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.


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