Methazolamide
Chemical compound
- S01EC05 (WHO)
- US: ℞-only
- N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
- 554-57-4 Y
- 4100
- 6828
- DB00703 Y
- 3958 Y
- W733B0S9SD
- D00655 N
- ChEMBL19 N
- DTXSID1023281
- Interactive image
- O=S(=O)(C\1=N\N(C(=N/C(=O)C)/S/1)C)N
- InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4- Y
- Key:FLOSMHQXBMRNHR-DAXSKMNVSA-N Y
Methazolamide (trade name Neptazane) is a potent carbonic anhydrase inhibitor. It is indicated in the treatment of increased intraocular pressure (IOP) in chronic open-angle glaucoma and secondary glaucoma. Also it is used preoperatively in acute angle-closure (narrow-angle) glaucoma where lowering the IOP is desired before surgery.
This drug has displayed teratogenic effects in rats. Compared to another drug in the same class, acetazolamide, methazolamide requires a lower dose when administered to patients.
References
- Iyer G, Bellantone R, Taft D (1999). "In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics". J Pharmacokinet Biopharm. 27 (1): 45–66. doi:10.1023/A:1020630712388. PMID 10533697. S2CID 24294348.
- RxList. "Neptazane". Archived from the original on August 12, 2006. Retrieved August 20, 2006.
- Shirato S, Kagaya F, Suzuki Y, Joukou S (1997). "Stevens–Johnson syndrome induced by methazolamide treatment". Arch Ophthalmol. 115 (4): 550–3. doi:10.1001/archopht.1997.01100150552021. PMID 9109770.
- Skorobohach B, Ward D, Hendrix D (2003). "Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs". Am J Vet Res. 64 (2): 183–7. doi:10.2460/ajvr.2003.64.183. PMID 12602587.
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muscarinic | |
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muscarinic/nicotinic | |
acetylcholinesterase inhibitors |
(sulfonamides)
- Acetazolamide
- Brinzolamide (+timolol, +brimonidine)
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- Dorzolamide (+timolol)
- Methazolamide
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