OSGEP

Protein-coding gene in the species Homo sapiens
OSGEP
Identifiers
AliasesOSGEP, Osgep, 1500019L24Rik, GCPL-1, PRSMG1, GCPL1, KAE1, OSGEP1, O-sialoglycoprotein endopeptidase, TCS3, GAMOS3
External IDsOMIM: 610107; MGI: 1913496; HomoloGene: 6395; GeneCards: OSGEP; OMA:OSGEP - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for OSGEP
Genomic location for OSGEP
Band14q11.2Start20,446,401 bp[1]
End20,455,089 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for OSGEP
Genomic location for OSGEP
Band14|14 C1Start51,143,935 bp[2]
End51,162,350 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • anterior pituitary

  • right lobe of thyroid gland

  • granulocyte

  • left lobe of thyroid gland

  • right uterine tube

  • right ovary

  • left ovary

  • right frontal lobe

  • canal of the cervix
Top expressed in
  • interventricular septum

  • ventricular zone

  • neural layer of retina

  • muscle of thigh

  • maxillary prominence

  • mandibular prominence

  • neural tube

  • endocardial cushion

  • somite

  • epiblast
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • acyltransferase activity
  • metal ion binding
  • N(6)-L-threonylcarbamoyladenine synthase activity
  • protein binding
  • acyltransferase activity, transferring groups other than amino-acyl groups
Cellular component
  • nucleoplasm
  • plasma membrane
  • nuclear speck
  • nucleus
  • EKC/KEOPS complex
  • cytoplasm
Biological process
  • tRNA processing
  • tRNA threonylcarbamoyladenosine modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55644

66246

Ensembl

ENSG00000092094

ENSMUSG00000006289

UniProt

Q9NPF4

Q8BWU5

RefSeq (mRNA)

NM_017807

NM_133676

RefSeq (protein)

NP_060277

NP_598437

Location (UCSC)Chr 14: 20.45 – 20.46 MbChr 14: 51.14 – 51.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable O-sialoglycoprotein endopeptidase is an enzyme in humans encoded by the OSGEP gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000092094 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006289 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seki Y, Ikeda S, Kiyohara H, Ayabe H, Seki T, Matsui H (May 2002). "Sequencing analysis of a putative human O-sialoglycoprotein endopeptidase gene (OSGEP) and analysis of a bidirectional promoter between the OSGEP and APEX genes". Gene. 285 (1–2): 101–8. doi:10.1016/S0378-1119(02)00429-8. PMID 12039036.
  6. ^ "Entrez Gene: OSGEP O-sialoglycoprotein endopeptidase".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Vickers JD, Packham MA, Kinlough-Rathbone RL (1997). "Differences between platelet phosphoinositide metabolism stimulated by thrombin or SFLLRN are not accounted for by interaction of thrombin with glycoprotein Ib". Am. J. Hematol. 54 (4): 288–95. doi:10.1002/(SICI)1096-8652(199704)54:4<288::AID-AJH5>3.0.CO;2-R. PMID 9092683. S2CID 22989321.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Chervenak JL, Illsley NP (2000). "Episialin acts as an antiadhesive factor in an in vitro model of human endometrial-blastocyst attachment". Biol. Reprod. 63 (1): 294–300. doi:10.1095/biolreprod63.1.294. PMID 10859271.
  • Kinoshita M, Nakamura T, Ihara M, et al. (2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Lett. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125. S2CID 23615506.
  • Armerding D, Fuhlbrigge RC, Kieffer JD, Kupper TS (2001). "Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity". Int. Arch. Allergy Immunol. 126 (1): 78–90. doi:10.1159/000049497. PMID 11641609. S2CID 45610233.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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