PCNX

Protein-coding gene in the species Homo sapiens
PCNX1
Identifiers
AliasesPCNX1, PCNXL1, pecanex, PCNX, pecanex homolog 1 (Drosophila), pecanex homolog 1, pecanex 1
External IDsOMIM: 617655; MGI: 1891924; HomoloGene: 40997; GeneCards: PCNX1; OMA:PCNX1 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for PCNX1
Genomic location for PCNX1
Band14q24.2Start70,907,405 bp[1]
End71,115,382 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for PCNX1
Genomic location for PCNX1
Band12|12 D1Start81,906,797 bp[2]
End82,047,698 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of colon

  • Brodmann area 23

  • sural nerve

  • middle temporal gyrus

  • Achilles tendon

  • ventricular zone

  • parietal pleura

  • blood

  • Skeletal muscle tissue of rectus abdominis

  • visceral pleura
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • Epithelium of choroid plexus

  • epithelium of lens

  • retinal pigment epithelium

  • spermatocyte

  • spermatid

  • neural layer of retina

  • temporal muscle

  • granulocyte

  • sternocleidomastoid muscle
More reference expression data
BioGPS


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22990

54604

Ensembl

ENSG00000100731

ENSMUSG00000021140

UniProt

Q96RV3

Q9QYC1

RefSeq (mRNA)

NM_001308160
NM_014982

NM_018814

RefSeq (protein)

NP_001295089
NP_055797

NP_061284

Location (UCSC)Chr 14: 70.91 – 71.12 MbChr 12: 81.91 – 82.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pecanex-like protein 1 is a protein that in humans is encoded by the PCNX gene.[5][6][7] The gene is found in Homo sapiens, and functions as a competitive endogenous RNA of S-phase kinase associated protein 2 in lung cancer.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100731 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021140 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Roux AF, Rommens JM, Read L, Duncan AM, Cox DW (July 1997). "Physical and transcription map in the region 14q24.3: identification of six novel transcripts". Genomics. 43 (2): 130–40. doi:10.1006/geno.1997.4786. PMID 9244429.
  6. ^ Geisinger A, Alsheimer M, Baier A, Benavente R, Wettstein R (April 2005). "The mammalian gene pecanex 1 is differentially expressed during spermatogenesis". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1728 (1–2): 34–43. doi:10.1016/j.bbaexp.2005.01.010. PMID 15777640.
  7. ^ "Entrez Gene: PCNX pecanex homolog (Drosophila)".
  8. ^ "PCNX1 pecanex 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-10-18.
  9. ^ Li J, Tian H, Pan J, Jiang N, Yang J, Zhou C, Xu D, Meng X, Gong Z (October 2017). "Pecanex functions as a competitive endogenous RNA of S-phase kinase associated protein 2 in lung cancer". Cancer Letters. 406: 36–46. doi:10.1016/j.canlet.2017.07.030. PMID 28789966.

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. CiteSeerX 10.1.1.529.4378. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.


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