PDE1B

Protein-coding gene in the species Homo sapiens

PDE1B

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1TAZ, 4NPV, 4NPW, 5B25

Identifiers

Aliases

PDE1B, PDE1B1, PDES1B, HEL-S-79p, phosphodiesterase 1B

External IDs

OMIM: 171891; MGI: 97523; HomoloGene: 37370; GeneCards: PDE1B; OMA:PDE1B - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.2	Start	54,549,601 bp^[1]
Band	12q13.2	End	54,579,239 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 F3	Start	103,411,461 bp^[2]
Band	15\|15 F3	End	103,438,479 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

caudate nucleus

nucleus accumbens

putamen

gastric mucosa

right frontal lobe

prefrontal cortex

Descending thoracic aorta

Brodmann area 9

cingulate gyrus

anterior cingulate cortex

Top expressed in

olfactory tubercle

nucleus accumbens

superior frontal gyrus

globus pallidus

ventricular zone

perirhinal cortex

granulocyte

entorhinal cortex

dentate gyrus of hippocampal formation granule cell

superior colliculus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity metal ion binding calmodulin binding cyclic-nucleotide phosphodiesterase activity calmodulin-dependent cyclic-nucleotide phosphodiesterase activity protein binding phosphoric diester hydrolase activity hydrolase activity calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity
Cellular component	cytoplasm neuronal cell body cytosol
Biological process	visual learning regulation of neurotransmitter levels cAMP catabolic process locomotory behavior response to amphetamine serotonin metabolic process monocyte differentiation regulation of dopamine metabolic process cellular response to macrophage colony-stimulating factor stimulus cGMP catabolic process cellular response to granulocyte macrophage colony-stimulating factor stimulus apoptotic process signal transduction G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5153


18574

Ensembl


ENSG00000123360


ENSMUSG00000022489

UniProt


Q01064


Q01065

RefSeq (mRNA)

NM_000924 NM_001165975 NM_001288768 NM_001288769 NM_001315534
NM_001315535


NM_001285890 NM_008800 NM_001357980

RefSeq (protein)

NP_000915 NP_001159447 NP_001275697 NP_001275698 NP_001302463
NP_001302464


NP_001272819 NP_032826 NP_001344909

Location (UCSC)

Chr 12: 54.55 – 54.58 Mb

Chr 15: 103.41 – 103.44 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123360 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022489 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jiang X, Li J, Paskind M, Epstein PM (Nov 1996). "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells". Proc Natl Acad Sci U S A. 93 (20): 11236–41. Bibcode:1996PNAS...9311236J. doi:10.1073/pnas.93.20.11236. PMC 1074519. PMID 8855339.
^ Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R (Feb 1998). "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1". Cell Signal. 9 (7): 519–29. doi:10.1016/S0898-6568(97)00046-6. PMID 9419816.
^ "Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent".

Repaske DR, Swinnen JV, Jin SL, et al. (1992). "A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase". J. Biol. Chem. 267 (26): 18683–8. doi:10.1016/S0021-9258(19)37015-2. PMID 1326532.
Spence S, Rena G, Sullivan M, et al. (1997). "Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase". Biochem. J. 321 ( Pt 1) (Pt 1): 157–63. doi:10.1042/bj3210157. PMC 1218050. PMID 9003415.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bender AT, Ostenson CL, Wang EH, Beavo JA (2005). "Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (2): 497–502. Bibcode:2005PNAS..102..497B. doi:10.1073/pnas.0408535102. PMC 544304. PMID 15625104.
Bender AT, Beavo JA (2006). "PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte". Proc. Natl. Acad. Sci. U.S.A. 103 (2): 460–5. Bibcode:2006PNAS..103..460B. doi:10.1073/pnas.0509972102. PMC 1326187. PMID 16407168.