PEX11A

Protein-coding gene in the species Homo sapiens
PEX11A
Identifiers
AliasesPEX11A, PEX11-ALPHA, PMP28, hsPEX11p, peroxisomal biogenesis factor 11 alpha, PEX11alpha
External IDsOMIM: 603866; MGI: 1338788; HomoloGene: 20829; GeneCards: PEX11A; OMA:PEX11A - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for PEX11A
Genomic location for PEX11A
Band15q26.1Start89,677,764 bp[1]
End89,690,783 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for PEX11A
Genomic location for PEX11A
Band7|7 D2Start79,385,705 bp[2]
End79,392,879 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • germinal epithelium

  • mucosa of transverse colon

  • parotid gland

  • adipose tissue

  • lactiferous gland

  • right lobe of liver

  • mucosa of sigmoid colon

  • palpebral conjunctiva

  • subcutaneous adipose tissue
Top expressed in
  • salivary gland

  • lacrimal gland

  • brown adipose tissue

  • parotid gland

  • left lobe of liver

  • right kidney

  • submandibular gland

  • zygote

  • Paneth cell

  • proximal tubule
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • protein homodimerization activity
Cellular component
  • integral component of membrane
  • peroxisomal membrane
  • peroxisome
  • membrane
  • integral component of peroxisomal membrane
  • protein-containing complex
Biological process
  • regulation of peroxisome size
  • peroxisome membrane biogenesis
  • peroxisome organization
  • signal transduction
  • peroxisome fission
  • brown fat cell differentiation
  • regulation of lipid metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8800

18631

Ensembl

ENSG00000166821

ENSMUSG00000030545

UniProt

O75192

Q9Z211

RefSeq (mRNA)

NM_003847
NM_001271572
NM_001271573

NM_011068

RefSeq (protein)

NP_001258501
NP_001258502
NP_003838

NP_035198

Location (UCSC)Chr 15: 89.68 – 89.69 MbChr 7: 79.39 – 79.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peroxisomal membrane protein 11A is a protein that in humans is encoded by the PEX11A gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166821 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030545 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (Dec 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem. 273 (45): 29607–14. doi:10.1074/jbc.273.45.29607. PMID 9792670.
  6. ^ "Entrez Gene: PEX11A peroxisomal biogenesis factor 11A".

Further reading

  • Abe I, Okumoto K, Tamura S, Fujiki Y (1998). "Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11". FEBS Lett. 431 (3): 468–72. doi:10.1016/S0014-5793(98)00815-1. PMID 9714566.
  • South ST, Gould SJ (1999). "Peroxisome Synthesis in the Absence of Preexisting Peroxisomes". J. Cell Biol. 144 (2): 255–66. doi:10.1083/jcb.144.2.255. PMC 2132891. PMID 9922452.
  • Sacksteder KA, Jones JM, South ST, et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Shimizu M, Akter MH, Emi Y, et al. (2007). "Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective transactivation of the perilipin/PEX11 alpha gene pair". J. Biochem. 139 (3): 563–73. doi:10.1093/jb/mvj053. PMID 16567422.
  • Orth T, Reumann S, Zhang X, et al. (2007). "The PEROXIN11 Protein Family Controls Peroxisome Proliferation in Arabidopsis". Plant Cell. 19 (1): 333–50. doi:10.1105/tpc.106.045831. PMC 1820951. PMID 17220199.


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