PIK3R4

Protein-coding gene in the species Homo sapiens
PIK3R4
Identifiers
AliasesPIK3R4, VPS15, p150, phosphoinositide-3-kinase regulatory subunit 4
External IDsOMIM: 602610 MGI: 1922919 HomoloGene: 24678 GeneCards: PIK3R4
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PIK3R4
Genomic location for PIK3R4
Band3q22.1Start130,678,934 bp[1]
End130,746,829 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for PIK3R4
Genomic location for PIK3R4
Band9 F1|9 56.79 cMStart105,520,177 bp[2]
End105,564,856 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • anterior pituitary

  • right lobe of thyroid gland

  • Brodmann area 9

  • left lobe of thyroid gland

  • upper lobe of left lung

  • right lung

  • tibial nerve

  • skin of abdomen

  • right coronary artery
Top expressed in
  • secondary oocyte

  • motor neuron

  • medullary collecting duct

  • iris

  • facial motor nucleus

  • primitive streak

  • semi-lunar valve

  • retinal pigment epithelium

  • supraoptic nucleus

  • trigeminal ganglion
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • protein kinase activity
  • nucleotide binding
  • kinase activity
  • protein serine/threonine kinase activity
  • protein binding
  • ATP binding
  • 1-phosphatidylinositol-3-kinase activity
Cellular component
  • cytosol
  • endosome
  • late endosome
  • phagocytic vesicle membrane
  • membrane
  • phosphatidylinositol 3-kinase complex, class III
  • nuclear pore
  • autophagosome
  • phosphatidylinositol 3-kinase complex, class III, type I
  • axoneme
  • nucleus-vacuole junction
  • cytoplasmic vesicle
  • phosphatidylinositol 3-kinase complex, class III, type II
  • microtubule cytoskeleton
  • intracellular membrane-bounded organelle
Biological process
  • cellular response to glucose starvation
  • regulation of cytokinesis
  • phosphorylation
  • late endosome to vacuole transport
  • autophagy of peroxisome
  • receptor catabolic process
  • positive regulation of phosphatidylinositol 3-kinase activity
  • protein phosphorylation
  • phosphatidylinositol biosynthetic process
  • protein targeting to vacuole
  • toll-like receptor 9 signaling pathway
  • macroautophagy
  • phosphatidylinositol-3-phosphate biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

30849

75669

Ensembl

ENSG00000196455

ENSMUSG00000032571

UniProt

Q99570

Q8VD65

RefSeq (mRNA)

NM_014602

NM_001081309
NM_029380

RefSeq (protein)

NP_055417

NP_001074778

Location (UCSC)Chr 3: 130.68 – 130.75 MbChr 9: 105.52 – 105.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196455 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032571 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 [ Homo sapiens (human) ]".
  6. ^ Panaretou C, Domin J, Cockcroft S, Waterfield MD (January 1997). "Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex". J. Biol. Chem. 272 (4): 2477–85. doi:10.1074/jbc.272.4.2477. PMID 8999962.

Further reading

  • Askham JM, Vaughan KT, Goodson HV, Morrison EE (2002). "Evidence That an Interaction between EB1 and p150Glued Is Required for the Formation and Maintenance of a Radial Microtubule Array Anchored at the Centrosome". Mol. Biol. Cell. 13 (10): 3627–45. doi:10.1091/mbc.E02-01-0061. PMC 129971. PMID 12388762.
  • Koyasu S (2003). "The role of PI3K in immune cells". Nat. Immunol. 4 (4): 313–9. doi:10.1038/ni0403-313. PMID 12660731. S2CID 9951653.
  • Matsunaga K, Saitoh T, Tabata K, et al. (2009). "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages". Nat. Cell Biol. 11 (4): 385–96. doi:10.1038/ncb1846. PMID 19270696. S2CID 205286778.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Takeshita F, Gursel I, Ishii KJ, et al. (2004). "Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9". Semin. Immunol. 16 (1): 17–22. doi:10.1016/j.smim.2003.10.009. PMID 14751759.
  • Ligon LA, Shelly SS, Tokito M, Holzbaur EL (2003). "The Microtubule Plus-End Proteins EB1 and Dynactin Have Differential Effects on Microtubule Polymerization". Mol. Biol. Cell. 14 (4): 1405–17. doi:10.1091/mbc.E02-03-0155. PMC 153110. PMID 12686597.
  • Yan Y, Flinn RJ, Wu H, et al. (2009). "hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells". Biochem. J. 417 (3): 747–55. doi:10.1042/BJ20081865. PMC 2652830. PMID 18957027.
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Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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