Protein wntless homolog

Protein-coding gene in the species Homo sapiens
WLS
Identifiers
AliasesWLS, C1orf139, EVI, GPR177, MRP, mig-14, wntless Wnt ligand secretion mediator, Wnt ligand secretion mediator, ZKS
External IDsOMIM: 611514; MGI: 1915401; HomoloGene: 11779; GeneCards: WLS; OMA:WLS - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for WLS
Genomic location for WLS
Band1p31.3Start68,098,473 bp[1]
End68,233,120 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for WLS
Genomic location for WLS
Band3|3 H4Start159,545,309 bp[2]
End159,644,300 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • Epithelium of choroid plexus

  • retinal pigment epithelium

  • corpus epididymis

  • gastric mucosa

  • islet of Langerhans

  • gallbladder

  • optic nerve

  • endothelial cell

  • bronchial epithelial cell
Top expressed in
  • calvaria

  • molar

  • left lung lobe

  • olfactory epithelium

  • pineal gland

  • choroid plexus of fourth ventricle

  • maxillary prominence

  • right kidney

  • corneal stroma

  • seminal vesicula
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • Wnt-protein binding
  • mu-type opioid receptor binding
Cellular component
  • integral component of membrane
  • endocytic vesicle membrane
  • endosome
  • Golgi apparatus
  • early endosome membrane
  • membrane
  • plasma membrane
  • dendrite membrane
  • trans-Golgi network
  • early endosome
  • dendrite cytoplasm
  • extracellular exosome
  • cytoplasmic vesicle membrane
  • endoplasmic reticulum membrane
  • cytoplasmic vesicle
  • Golgi membrane
  • endoplasmic reticulum
Biological process
  • exocrine pancreas development
  • positive regulation of canonical Wnt signaling pathway
  • positive regulation of Wnt protein secretion
  • mesoderm formation
  • hindbrain development
  • multicellular organism development
  • positive regulation of Wnt signaling pathway
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • intracellular protein transport
  • anterior/posterior axis specification
  • midbrain development
  • Wnt signaling pathway
  • Wnt protein secretion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79971

68151

Ensembl

ENSG00000116729

ENSMUSG00000028173

UniProt

Q5T9L3

Q6DID7

RefSeq (mRNA)

NM_001002292
NM_001193334
NM_024911

NM_026582
NM_001356349
NM_001356350

RefSeq (protein)

NP_001002292
NP_001180263
NP_079187

NP_080858
NP_001343278
NP_001343279

Location (UCSC)Chr 1: 68.1 – 68.23 MbChr 3: 159.55 – 159.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein wntless homolog, commonly known as Wntless, is encoded in humans by the WLS gene .[5] Wntless is a receptor for Wnt proteins in Wnt-secreting cells.[6]

Wntless was shown to be a cargo for the retromer complex.[6] It has been found essential for hair follicle induction.[7]

A homozygous missense mutation in the WLS gene was identified in Zaki syndrome.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116729 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028173 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "WLS - Protein wntless homolog - Homo sapiens (Human) - WLS gene & protein". www.uniprot.org. Retrieved 30 May 2022.
  6. ^ a b Eaton S (January 2008). "Retromer retrieves wntless". Developmental Cell. 14 (1): 4–6. doi:10.1016/j.devcel.2007.12.014. PMID 18194646.
  7. ^ Fu J, Hsu W (April 2013). "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis". The Journal of Investigative Dermatology. 133 (4): 890–8. doi:10.1038/jid.2012.407. PMC 3594635. PMID 23190887.
  8. ^ Chai G, Szenker-Ravi E, Chung C, Li Z, Wang L, Khatoo M, Marshall T, Jiang N, Yang X, McEvoy-Venneri J, Stanley V (2021-09-29). "A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion". New England Journal of Medicine. 385 (14): 1292–1301. doi:10.1056/NEJMoa2033911. PMC 9017221. PMID 34587386.

Further reading

  • Bänziger C, Soldini D, Schütt C, Zipperlen P, Hausmann G, Basler K (May 2006). "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells". Cell. 125 (3): 509–22. doi:10.1016/j.cell.2006.02.049. PMID 16678095. S2CID 7841408.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.

See also

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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