RNASET2

Protein-coding gene in the species Homo sapiens
RNASET2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3T0O

Identifiers
AliasesRNASET2, RNASE6PL, bA514O12.3, ribonuclease T2
External IDsOMIM: 612944; MGI: 3702087; HomoloGene: 31190; GeneCards: RNASET2; OMA:RNASET2 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for RNASET2
Genomic location for RNASET2
Band6q27Start166,922,113 bp[1]
End166,957,191 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for RNASET2
Genomic location for RNASET2
Band17|17 A1Start7,238,033 bp[2]
End7,278,698 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • granulocyte

  • blood

  • monocyte

  • spleen

  • parotid gland

  • seminal vesicula

  • olfactory bulb

  • lymph node

  • inferior ganglion of vagus nerve
Top expressed in
  • right kidney

  • granulocyte

  • muscle of thigh

  • lip

  • zygote

  • esophagus

  • genital tubercle

  • dentate gyrus of hippocampal formation granule cell

  • ventricular zone

  • morula
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • hydrolase activity
  • ribonuclease T2 activity
  • endonuclease activity
  • nuclease activity
  • RNA binding
  • ribonuclease activity
  • endoribonuclease activity
Cellular component
  • lysosomal lumen
  • endoplasmic reticulum lumen
  • lysosome
  • endoplasmic reticulum
  • extracellular exosome
  • extracellular region
  • extracellular space
  • azurophil granule lumen
Biological process
  • nucleic acid phosphodiester bond hydrolysis
  • RNA phosphodiester bond hydrolysis, endonucleolytic
  • RNA catabolic process
  • RNA phosphodiester bond hydrolysis
  • neutrophil degranulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8635

68195

Ensembl

ENSG00000026297

ENSMUSG00000094724

UniProt

O00584

Q5FWA0

RefSeq (mRNA)

NM_003730
NM_017795
NM_018726

NM_026611
NM_029204

RefSeq (protein)

NP_003721

NP_080887
NP_001077407
NP_080887

Location (UCSC)Chr 6: 166.92 – 166.96 MbChr 17: 7.24 – 7.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribonuclease T2 is an enzyme that in humans is encoded by the RNASET2 gene.[5][6] It is a type of endoribonuclease.

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.[6] RNASET2 has been reported as a tumour associated antigen in anaplastic large cell lymphoma and other lymphomas.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000026297 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000094724 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Trubia M, Sessa L, Taramelli R (Sep 1997). "Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies". Genomics. 42 (2): 342–344. doi:10.1006/geno.1997.4679. PMID 9192857.
  6. ^ a b "Entrez Gene: RNASET2 ribonuclease T2".
  7. ^ Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CS, Liggins AP, Taramelli R, Banham AH, Acquati F, Murphy D, Pulford K (Sep 2012). "RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis". J Proteomics. 75 (17): 5279–5292. doi:10.1016/j.jprot.2012.06.009. PMID 22732457.

Further reading

  • Acquati F, Morelli C, Cinquetti R, et al. (2001). "Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27". Oncogene. 20 (8): 980–988. doi:10.1038/sj.onc.1204178. PMID 11314033.
  • Liu Y, Emilion G, Mungall AJ, et al. (2002). "Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer". Oncogene. 21 (3): 387–399. doi:10.1038/sj.onc.1205067. PMID 11821951.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Acquati F, Possati L, Ferrante L, et al. (2005). "Tumor and metastasis suppression by the human RNASET2 gene". Int. J. Oncol. 26 (5): 1159–68. doi:10.3892/ijo.26.5.1159. PMID 15809705.
  • Campomenosi P, Salis S, Lindqvist C, et al. (2006). "Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins". Arch. Biochem. Biophys. 449 (1–2): 17–26. doi:10.1016/j.abb.2006.02.022. PMID 16620762.
  • Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CS, Liggins AP, Taramelli R, Banham AH, Acquati F, Murphy D, Pulford K (2012). "RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis". J Proteomics. 75 (17): 5279–5292. doi:10.1016/j.jprot.2012.06.009. PMID 22732457.


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