SNX9

Protein-coding gene in the species Homo sapiens

SNX9

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2RAI, 2RAJ, 2RAK, 3DYT, 3DYU, 3LGE

Identifiers

Aliases

SNX9, SDP1, SH3PX1, SH3PXD3A, WISP, sorting nexin 9

External IDs

OMIM: 605952; MGI: 1913866; HomoloGene: 49454; GeneCards: SNX9; OMA:SNX9 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q25.3	Start	157,700,387 bp^[1]
Band	6q25.3	End	157,945,077 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17 A1\|17 3.51 cM	Start	5,891,604 bp^[2]
Band	17 A1\|17 3.51 cM	End	5,982,229 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cartilage tissue

mucosa of ileum

superficial temporal artery

Achilles tendon

decidua

right coronary artery

tendon of biceps brachii

tail of epididymis

synovial membrane

tibial arteries

Top expressed in

Ileal epithelium

zygote

secondary oocyte

primary oocyte

choroid plexus of fourth ventricle

jejunum

lactiferous gland

duodenum

right kidney

calvaria

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein homodimerization activity Arp2/3 complex binding 1-phosphatidylinositol binding protein binding phosphatidylinositol binding ubiquitin protein ligase binding lipid binding cadherin binding identical protein binding
Cellular component	cytoplasm Golgi apparatus cell projection membrane ruffle extrinsic component of cytoplasmic side of plasma membrane plasma membrane trans-Golgi network extracellular exosome cytoplasmic vesicle membrane clathrin-coated vesicle cytosol cytoplasmic vesicle cuticular plate
Biological process	endocytosis cleavage furrow formation mitotic cytokinesis positive regulation of membrane protein ectodomain proteolysis receptor-mediated endocytosis plasma membrane tubulation cell division endosomal transport positive regulation of GTPase activity positive regulation of protein oligomerization protein transport lipid tube assembly cell cycle intracellular protein transport positive regulation of protein kinase activity membrane organization mitotic cell cycle transport positive regulation of actin filament polymerization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51429


66616

Ensembl


ENSG00000130340


ENSMUSG00000002365

UniProt


Q9Y5X1


Q91VH2

RefSeq (mRNA)


NM_016224


NM_025664

RefSeq (protein)


NP_057308


NP_079940

Location (UCSC)

Chr 6: 157.7 – 157.95 Mb

Chr 17: 5.89 – 5.98 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.^[5]^[6]^[7]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.^[7]

Interactions

SNX9 has been shown to interact with ADAM9,^[5] DNM2^[8] and ADAM15.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130340 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002365 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Howard L; Nelson KK; Maciewicz RA; Blobel CP (Dec 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
^ Yarar D; Waterman-Storer CM; Schmid SL (Jul 2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis". Dev Cell. 13 (1): 43–56. doi:10.1016/j.devcel.2007.04.014. PMID 17609109.
^ ^a ^b "Entrez Gene: SNX9 sorting nexin 9".
^ Lundmark, Richard; Carlsson Sven R (Nov 2003). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. 278 (47). United States: 46772–81. doi:10.1074/jbc.M307334200. ISSN 0021-9258. PMID 12952949.

Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
Lin Q; Lo CG; Cerione RA; Yang W (2002). "The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation". J. Biol. Chem. 277 (12): 10134–8. doi:10.1074/jbc.M110329200. PMID 11799118.
Lundmark R; Carlsson SR (2002). "The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2". Biochem. J. 362 (Pt 3): 597–607. doi:10.1042/0264-6021:3620597. PMC 1222423. PMID 11879186.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lundmark R; Carlsson SR (2004). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. 278 (47): 46772–81. doi:10.1074/jbc.M307334200. PMID 12952949.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Schulze WX; Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc.M309909200. PMID 14679214.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B; Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Lundmark R; Carlsson SR (2004). "Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9". J. Biol. Chem. 279 (41): 42694–702. doi:10.1074/jbc.M407430200. PMID 15299020.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Soulet F; Yarar D; Leonard M; Schmid SL (2005). "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis". Mol. Biol. Cell. 16 (4): 2058–67. doi:10.1091/mbc.E04-11-1016. PMC 1073683. PMID 15703209.
Yeow-Fong L; Lim L; Manser E (2005). "SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1". FEBS Lett. 579 (22): 5040–8. doi:10.1016/j.febslet.2005.07.093. PMID 16137687. S2CID 44482842.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Childress C; Lin Q; Yang W (2006). "Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2". Biochem. J. 394 (Pt 3): 693–8. doi:10.1042/BJ20050576. PMC 1383719. PMID 16316319.
Marchès O, Batchelor M, Shaw RK, et al. (2006). "EspF of enteropathogenic Escherichia coli binds sorting nexin 9". J. Bacteriol. 188 (8): 3110–5. doi:10.1128/JB.188.8.3110-3115.2006. PMC 1447016. PMID 16585770.
Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly". PLOS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMC 1540706. PMID 16903783.
Badour K, McGavin MK, Zhang J, et al. (2007). "Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells". Proc. Natl. Acad. Sci. U.S.A. 104 (5): 1593–8. Bibcode:2007PNAS..104.1593B. doi:10.1073/pnas.0610543104. PMC 1785243. PMID 17242350.