SSBP3

Protein-coding gene in the species Homo sapiens

SSBP3

Identifiers

Aliases

SSBP3, CSDP, SSDP, SSDP1, single stranded DNA binding protein 3

External IDs

OMIM: 607390 MGI: 1919725 HomoloGene: 23411 GeneCards: SSBP3

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p32.3	Start	54,225,433 bp^[1]
Band	1p32.3	End	54,413,479 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 C7	Start	106,767,898 bp^[2]
Band	4\|4 C7	End	106,906,891 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

popliteal artery

prefrontal cortex

canal of the cervix

right coronary artery

cerebellar hemisphere

dorsolateral prefrontal cortex

body of stomach

ganglionic eminence

Brodmann area 9

left coronary artery

Top expressed in

superior frontal gyrus

cerebellar cortex

ganglionic eminence

ascending aorta

hand

maxillary prominence

thymus

aortic valve

primary motor cortex

medullary collecting duct

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	single-stranded DNA binding DNA binding protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific
Cellular component	nucleus protein-containing complex
Biological process	midbrain-hindbrain boundary initiation positive regulation of transcription, DNA-templated prechordal plate formation head morphogenesis positive regulation of anterior head development regulation of transcription, DNA-templated hematopoietic progenitor cell differentiation transcription, DNA-templated positive regulation of cell population proliferation transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II head development protein-containing complex assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23648


72475

Ensembl


ENSG00000157216


ENSMUSG00000061887

UniProt


Q9BWW4


Q9D032

RefSeq (mRNA)


NM_001009955 NM_018070 NM_145716


NM_023672 NM_198438 NM_001355532

RefSeq (protein)


NP_001009955 NP_060540 NP_663768


NP_076161 NP_940840 NP_001342461

Location (UCSC)

Chr 1: 54.23 – 54.41 Mb

Chr 4: 106.77 – 106.91 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Single-stranded DNA-binding protein 3 is a protein that in humans is encoded by the SSBP3 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157216 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061887 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Castro P, Liang H, Liang JC, Nagarajan L (July 2002). "A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity". Genomics. 80 (1): 78–85. doi:10.1006/geno.2002.6805. PMID 12079286.
^ "Entrez Gene: SSBP3 single stranded DNA binding protein 3".

Wu L (January 2006). "Structure and functional characterization of single-strand DNA binding protein SSDP1: carboxyl-terminal of SSDP1 has transcription activity". Biochemical and Biophysical Research Communications. 339 (3): 977–84. doi:10.1016/j.bbrc.2005.11.098. PMID 16325762.
Chen L, Segal D, Hukriede NA, Podtelejnikov AV, Bayarsaihan D, Kennison JA, Ogryzko VV, Dawid IB, Westphal H (October 2002). "Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development". Proceedings of the National Academy of Sciences of the United States of America. 99 (22): 14320–5. Bibcode:2002PNAS...9914320C. doi:10.1073/pnas.212532399. PMC 137882. PMID 12381786.
Raval-Fernandes S, Kickhoefer VA, Rome LH (September 1999). "Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus". Gene. 237 (1): 201–7. doi:10.1016/S0378-1119(99)00289-9. PMID 10524251.
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.

DNA replication (comparing prokaryotic to eukaryotic)

Initiation

Prokaryotic (initiation)	Pre-replication complex dnaC Helicase dnaA dnaB T7 Primase dnaG
Eukaryotic (preparation in G1 phase)	Pre-replication complex Origin recognition complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence Single-strand binding protein SSBP2 SSBP3 SSBP4 RNase H RNASEH1 RNASEH2A Helicase: HFM1 Primase: PRIM1 PRIM2
Both	Origin of replication/Ori/Replicon Replication fork Lagging and leading strands Okazaki fragments Primer

Replication

Prokaryotic (elongation)	DNA polymerase III holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase: DNA polymerase I Klenow fragment
Eukaryotic (synthesis in S phase)	Replication factor C RFC1 Flap endonuclease FEN1 Topoisomerase Replication protein A RPA1 Eukaryotic DNA polymerase: alpha POLA1 POLA2 PRIM1 PRIM2 delta POLD1 POLD2 POLD3 POLD4 epsilon POLE POLE2 POLE3 POLE4 DNA clamp PCNA Control of chromosome duplication
Both	Movement: Processivity DNA ligase