Solute carrier family 38 member 9

Protein-coding gene in the species Homo sapiens
SLC38A9
Identifiers
AliasesSLC38A9, URLC11, solute carrier family 38 member 9
External IDsOMIM: 616203; MGI: 1918839; HomoloGene: 18139; GeneCards: SLC38A9; OMA:SLC38A9 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SLC38A9
Genomic location for SLC38A9
Band5q11.2Start55,625,845 bp[1]
End55,773,194 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for SLC38A9
Genomic location for SLC38A9
Band13|13 D2.2Start112,797,285 bp[2]
End112,875,283 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • placenta

  • pancreatic epithelial cell

  • buccal mucosa cell

  • Achilles tendon

  • tibia

  • body of pancreas

  • germinal epithelium

  • gonad

  • bone marrow cells
Top expressed in
  • lumbar spinal ganglion

  • spermatid

  • spermatocyte

  • bone marrow

  • otolith organ

  • utricle

  • hand

  • secondary oocyte

  • seminal vesicula

  • pineal gland
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • amino acid transmembrane transporter activity
  • L-leucine transmembrane transporter activity
  • L-arginine transmembrane transporter activity
  • metal ion binding
Cellular component
  • integral component of membrane
  • endosome
  • Ragulator complex
  • late endosome
  • lysosome
  • membrane
  • late endosome membrane
  • nucleoplasm
  • intracellular membrane-bounded organelle
  • lysosomal membrane
  • integral component of lysosomal membrane
Biological process
  • cellular response to amino acid stimulus
  • amino acid transmembrane transport
  • amino acid transport
  • positive regulation of TOR signaling
  • regulation of macroautophagy
  • branched-chain amino acid transport
  • neutral amino acid transport
  • cation transmembrane transport
  • L-alpha-amino acid transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

153129

268706

Ensembl

ENSG00000177058

ENSMUSG00000047789

UniProt

Q8NBW4

Q8BGD6

RefSeq (mRNA)
NM_001258286
NM_001258287
NM_001282429
NM_173514
NM_001349382

NM_001349383
NM_001349384
NM_001349385

NM_175376
NM_178746

RefSeq (protein)
NP_001245215
NP_001245216
NP_001269358
NP_775785
NP_001336311

NP_001336312
NP_001336313
NP_001336314

NP_848861

Location (UCSC)Chr 5: 55.63 – 55.77 MbChr 13: 112.8 – 112.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 38 member 9 is a protein that in humans is encoded by the SLC38A9 gene. [5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177058 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047789 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier family 38 member 9". Retrieved 2018-08-06.

Further reading

  • Uchiyama K, Takagi T, Iwamoto Y, Kondo N, Okayama T, Yoshida N, Kamada K, Katada K, Handa O, Ishikawa T, Yasuda H, Sakagami J, Konishi H, Yagi N, Naito Y, Itoh Y (2014). "New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid". PLOS ONE. 9 (4): e95080. Bibcode:2014PLoSO...995080U. doi:10.1371/journal.pone.0095080. PMC 3999094. PMID 24762746.
  • Rebsamen M, Pochini L, Stasyk T, de Araújo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G (March 2015). "SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1". Nature. 519 (7544): 477–81. Bibcode:2015Natur.519..477R. doi:10.1038/nature14107. PMC 4376665. PMID 25561175.
  • Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM (January 2015). "Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1". Science. 347 (6218): 188–94. doi:10.1126/science.1257132. PMC 4295826. PMID 25567906.
  • Jung J, Genau HM, Behrends C (July 2015). "Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9". Mol. Cell. Biol. 35 (14): 2479–94. doi:10.1128/MCB.00125-15. PMC 4475919. PMID 25963655.


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