TMED10

Protein-coding gene

TMED10

Identifiers

Aliases

TMED10, P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1, transmembrane p24 trafficking protein 10

External IDs

OMIM: 605406; MGI: 3782198; HomoloGene: 4972; GeneCards: TMED10; OMA:TMED10 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q24.3	Start	75,131,469 bp^[1]
Band	14q24.3	End	75,176,612 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

parotid gland

islet of Langerhans

stromal cell of endometrium

germinal epithelium

beta cell

corpus epididymis

caput epididymis

olfactory zone of nasal mucosa

mucosa of sigmoid colon

skin of thigh

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding syntaxin binding protein-containing complex binding
Cellular component	integral component of membrane Golgi apparatus endoplasmic reticulum membrane secretory granule membrane membrane intracellular membrane-bounded organelle melanosome Golgi membrane cis-Golgi network plasma membrane transport vesicle membrane transport vesicle zymogen granule membrane endoplasmic reticulum ER to Golgi transport vesicle membrane trans-Golgi network transport vesicle endoplasmic reticulum-Golgi intermediate compartment membrane gamma-secretase complex cytoplasmic vesicle COPI-coated vesicle endoplasmic reticulum-Golgi intermediate compartment COPII-coated ER to Golgi transport vesicle
Biological process	regulation of amyloid-beta formation Golgi organization kidney development COPI coating of Golgi vesicle vesicle targeting, to, from or within Golgi COPI-coated vesicle budding endoplasmic reticulum to Golgi vesicle-mediated transport COPII vesicle coating response to alkaloid protein complex oligomerization vesicle cargo loading protein transport regulated exocytosis intracellular protein transport vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10972


100042773

Ensembl


ENSG00000170348


ENSMUSG00000114251

UniProt


P49755


n/a

RefSeq (mRNA)


NM_006827


XM_036158265

RefSeq (protein)


NP_006818


n/a

Location (UCSC)

Chr 14: 75.13 – 75.18 Mb

n/a

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Transmembrane emp24 domain-containing protein 10 is a protein that in humans is encoded by the TMED10 gene.^[4]^[5]^[6]

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170348 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al. (Aug 1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754–60. doi:10.1038/375754a0. PMID 7596406. S2CID 4308372.
^ Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (Sep 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". J Biol Chem. 271 (29): 17183–9. doi:10.1074/jbc.271.29.17183. PMID 8663407.
^ ^a ^b "Entrez Gene: TMED10 transmembrane emp24-like trafficking protein 10 (yeast)".

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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Gommel D, Orci L, Emig EM, et al. (1999). "p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway". FEBS Lett. 447 (2–3): 179–85. doi:10.1016/S0014-5793(99)00246-X. PMID 10214941.
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Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.