Thymopentin

Chemical compound
  • L03AX09 (WHO)
Identifiers
  • (3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
CAS Number
  • 69558-55-0 checkY
PubChem CID
  • 451417
ChemSpider
  • 397640 checkY
UNII
  • O3Y80ZF13F
KEGG
  • D06117 checkY
ChEMBL
  • ChEMBL156025 checkY
NIAID ChemDB
  • 000127
CompTox Dashboard (EPA)
  • DTXSID9046609 Edit this at Wikidata
ECHA InfoCard100.242.320 Edit this at WikidataChemical and physical dataFormulaC30H49N9O9Molar mass679.776 g·mol−13D model (JSmol)
  • Interactive image
  • O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(O)cc1)C(C)C)CC(=O)O)CCCCN)[C@@H](N)CCC/N=C(\N)N
InChI
  • InChI=1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1 checkY
  • Key:PSWFFKRAVBDQEG-YGQNSOCVSA-N checkY
  (verify)

Thymopentin is an immunostimulant. As such, it has been used in several clinical studies in the early years of the AIDS pandemic (from 1983 to 1985). Thymopentin helped to improve immunological condition in several patients for a brief time under specific treatments.[1][2][3]

It interacts with T cells.[4]

It is a thymic polypeptide.[5]

References

  1. ^ Mascart-Lemone F, Huygen K, Clumeck N, Brenez D, Bolla K, Duchateau J (1983). "Stimulation of cellular function by thymopentin (TP-5) in three AIDS patients". Lancet. 322 (8352): 735–736. doi:10.1016/S0140-6736(83)92271-7. PMID 6193382. S2CID 519367.
  2. ^ Clumeck N, Van de Perre P, Mascart-Lemone F, Cran S, Bolla K, Duchateau J (1984). "Preliminary results on clinical and immunological effects of thymopentin in AIDS". Int J Clin Pharmacol Res. 4 (6): 459–463. PMID 6398315.
  3. ^ Clumeck N, Cran S, Van de Perre P, Mascart-Lemone F, Duchateau J, Bolla K (1985). "Thymopentin treatment in AIDS and pre-AIDS patients". Surv Immunol Res. 4 (1): supp1 58–62. doi:10.1007/BF02919057. PMID 3898293. S2CID 36555170.
  4. ^ Liu Z, Zheng X, Wang J, Wang E (2007). Egli M (ed.). "Molecular analysis of thymopentin binding to HLA-DR molecules". PLOS ONE. 2 (12): e1348. Bibcode:2007PLoSO...2.1348L. doi:10.1371/journal.pone.0001348. PMC 2137936. PMID 18159232. Open access icon
  5. ^ Peng Y, Chen Z, Yu W, et al. (July 2008). "Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells". Cell Biology International. 32 (10): 1265–71. doi:10.1016/j.cellbi.2008.07.011. PMID 18692582. S2CID 24144448.
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