UQCRC1

Protein-coding gene in the species Homo sapiens
UQCRC1
Identifiers
AliasesUQCRC1, D3S3191, QCR1, UQCR1, ubiquinol-cytochrome c reductase core protein I, ubiquinol-cytochrome c reductase core protein 1, PKNPY
External IDsOMIM: 191328; MGI: 107876; HomoloGene: 2525; GeneCards: UQCRC1; OMA:UQCRC1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for UQCRC1
Genomic location for UQCRC1
Band3p21.31Start48,599,002 bp[1]
End48,610,976 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for UQCRC1
Genomic location for UQCRC1
Band9 F2|9 59.63 cMStart108,765,701 bp[2]
End108,778,691 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • left ventricle

  • right ventricle

  • triceps brachii muscle

  • myocardium of left ventricle

  • gastrocnemius muscle

  • muscle of thigh

  • mucosa of transverse colon

  • right auricle

  • vastus lateralis muscle
Top expressed in
  • proximal tubule

  • heart

  • right kidney

  • muscle tissue

  • muscle of thigh

  • skeletal muscle tissue

  • quadriceps femoris muscle

  • human kidney

  • neural layer of retina

  • duodenum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ubiquinol-cytochrome-c reductase activity
  • protein-containing complex binding
  • zinc ion binding
  • metal ion binding
  • catalytic activity
  • metalloendopeptidase activity
  • ubiquitin protein ligase binding
Cellular component
  • mitochondrial respiratory chain complex III
  • membrane
  • myelin sheath
  • mitochondrion
  • mitochondrial respirasome
  • mitochondrial inner membrane
  • respirasome
  • cytosol
Biological process
  • protein processing
  • response to activity
  • aerobic respiration
  • oxidative phosphorylation
  • response to alkaloid
  • mitochondrial electron transport, ubiquinol to cytochrome c
  • proton transmembrane transport
  • proteolysis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7384

22273

Ensembl

ENSG00000010256

ENSMUSG00000025651

UniProt

P31930

Q9CZ13

RefSeq (mRNA)

NM_003365

NM_025407

RefSeq (protein)

NP_003356

NP_079683

Location (UCSC)Chr 3: 48.6 – 48.61 MbChr 9: 108.77 – 108.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.[5][6]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000010256 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025651 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hoffman GG, Lee S, Christiano AM, Chung-Honet LC, Cheng W, Katchman S, Uitto J, Greenspan DS (Nov 1993). "Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase". J Biol Chem. 268 (28): 21113–9. doi:10.1016/S0021-9258(19)36900-5. PMID 8407948.
  6. ^ "Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I".

Further reading

  • Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T (1991). "Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system". J. Biol. Chem. 266 (4): 2333–8. doi:10.1016/S0021-9258(18)52248-1. PMID 1846623.
  • Broger C, Nałecz MJ, Azzi A (1980). "Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain". Biochim. Biophys. Acta. 592 (3): 519–27. doi:10.1016/0005-2728(80)90096-1. PMID 6251869.
  • Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (2): 410. PMID 7951059.
  • Islam MM, Tanaka M, Suzuki H, et al. (1995). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (4): 815. PMID 7981668.
  • Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 32 (5): 797–805. PMID 8069229.
  • Hughes GJ, Frutiger S, Paquet N, et al. (1994). "Human liver protein map: update 1993". Electrophoresis. 14 (11): 1216–22. doi:10.1002/elps.11501401181. PMID 8313870. S2CID 33424554.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Valnot I, Kassis J, Chretien D, et al. (1999). "A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency". Hum. Genet. 104 (6): 460–6. doi:10.1007/s004390050988. PMID 10453733. S2CID 30584267.
  • Hu WH, Hausmann ON, Yan MS, et al. (2002). "Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP)". J. Neurochem. 81 (1): 36–45. doi:10.1046/j.1471-4159.2002.00788.x. PMID 12067236. S2CID 38794348.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kulawiec M, Arnouk H, Desouki MM, et al. (2007). "Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer". Cancer Biol. Ther. 5 (8): 967–75. doi:10.4161/cbt.5.8.2880. PMID 16775426. S2CID 84608368.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • v
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  • 1be3: CYTOCHROME BC1 COMPLEX FROM BOVINE
    1be3: CYTOCHROME BC1 COMPLEX FROM BOVINE
  • 1bgy: CYTOCHROME BC1 COMPLEX FROM BOVINE
    1bgy: CYTOCHROME BC1 COMPLEX FROM BOVINE
  • 1l0l: structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone
    1l0l: structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone
  • 1l0n: native structure of bovine mitochondrial cytochrome bc1 complex
    1l0n: native structure of bovine mitochondrial cytochrome bc1 complex
  • 1ntk: Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1
    1ntk: Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1
  • 1ntm: Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom
    1ntm: Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom
  • 1ntz: Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone
    1ntz: Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone
  • 1nu1: Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO)
    1nu1: Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO)
  • 1pp9: Bovine cytochrome bc1 complex with stigmatellin bound
    1pp9: Bovine cytochrome bc1 complex with stigmatellin bound
  • 1ppj: Bovine cytochrome bc1 complex with stigmatellin and antimycin
    1ppj: Bovine cytochrome bc1 complex with stigmatellin and antimycin
  • 1qcr: CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY
    1qcr: CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY
  • 1sqq: Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS)
    1sqq: Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS)
  • 1sqv: Crystal Structure Analysis of Bovine Bc1 with UHDBT
    1sqv: Crystal Structure Analysis of Bovine Bc1 with UHDBT
  • 1sqx: Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A
    1sqx: Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A
  • 2a06: Bovine cytochrome bc1 complex with stigmatellin bound
    2a06: Bovine cytochrome bc1 complex with stigmatellin bound
  • 2fyu: Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor
    2fyu: Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor
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