ZBTB1

ZBTB1
Identifiers
Aliases	ZBTB1, ZNF909, zinc finger and BTB domain containing 1
External IDs	OMIM: 616578; MGI: 2442326; HomoloGene: 8974; GeneCards: ZBTB1; OMA:ZBTB1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.3 Start 64,503,712 bp[1] End 64,533,690 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 76,417,040 bp[2] End 76,443,724 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Achilles tendon lymph node right uterine tube mononuclear cell monocyte skin of hip cartilage tissue germinal epithelium stromal cell of endometrium Top expressed in cumulus cell lacrimal gland hair follicle trigeminal ganglion blood sciatic nerve lymph node conjunctival fornix female urethra ascending aorta More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein homodimerization activity metal ion binding K63-linked polyubiquitin modification-dependent protein binding protein binding protein heterodimerization activity nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nuclear body nucleoplasm nucleus nuclear membrane Biological process positive regulation of T cell differentiation chromatin remodeling cell differentiation positive regulation of pro-T cell differentiation regulation of transcription, DNA-templated positive regulation of natural killer cell differentiation T cell differentiation in thymus thymus development immune system process cellular response to UV mRNA transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of T cell mediated immunity translesion synthesis B cell differentiation innate immune response protein homooligomerization DNA repair cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22890 268564 Ensembl ENSG00000126804 ENSMUSG00000033454 UniProt Q9Y2K1 Q91VL9 RefSeq (mRNA) NM_001123329 NM_014950 NM_178744 NM_001364323 RefSeq (protein) NP_001116801 NP_055765 NP_848859 NP_001351252 Location (UCSC) Chr 14: 64.5 – 64.53 Mb Chr 12: 76.42 – 76.44 Mb PubMed search [3] [4]
Wikidata
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Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.^[5]

ZBTB1 is essential for the development of lymphocytes in mice: T cells are absent from ZBTB1 mutant mice, and numbers of B cells and natural killer cells are reduced.^[6][7]

References