Elastin

Za ostale upotrebe, v. Spandeks.

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Elastin

Identifikatori

ELN; SVAS; WBS; WS

Vanjski ID

OMIM: 130160 MGI: 95317 HomoloGene: 73880 GeneCards: ELN Gene

Ontologija gena
Molekulska funkcija	• strukturni sastojak ekstracelularnog matriksa • proteinsko vezivanje • sastojak ekstracelularnog matriksa koji proizvodi elastičnost
Ćelijska komponenta	• ekstracelularni region • proteinski ekstracelularni matriks
Biološki proces	• respiratorna gasna razmena • krvna cirkulacija • ćelijska proliferacija • morfogeneza organa

Ortolozi

Vrsta

Čovek

Miš

Entrez

2006

13717

Ensembl

ENSG00000049540

ENSMUSG00000029675

UniProt

P15502

P54320

Ref. Sekv. (iRNK)

NM_000501.2

NM_007925.3

Ref. Sekv. (protein)

NP_000492.2

NP_031951.2

Lokacija (UCSC)

Chr 7:
73.44 - 73.48 Mb

Chr 5:
135.18 - 135.22 Mb

PubMed pretraga

[1]

[2]

Elastin je sastavna komponenta ekstracelularnog matriksa. Mnoga tkiva i organi u organizmu zahtevaju da budu jaki i ujedno elastični (krvni sudovi, koža, pluća...), što omogućavaju elasinska vlakna. Elastin se uvek nalazi uz nerstegljiviji kolagen kako bi se ograničilo rastezanje samog tkiva koje izgrađuje. Kod ljudi, elastin je kodiran ELN genom.^[1]

Funkcija

Ovaj gen kodira protein koji jedna od dve komponente elastičnih vlakana. On je bogat u hidrofobnim aminokiselinama kao što su glicin i prolin, koje formiraju mobilne hidrofobne regione povezane unakrsnim vezama između lizinskih ostataka.^[2] Višestruke transkriptne varijante koje kodiraju različite izoforme ovog gena su nađene.^[2] Drugo ime za elastin je tropoelastin.^[3]^[4]

Reference

↑ Curran ME, Atkinson DL, Ewart AK, Morris CA, Leppert MF, Keating MT (April 1993). „The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis”. Cell 73 (1): 159–68. DOI:10.1016/0092-8674(93)90168-P. PMID 8096434.
↑ ^2,0 ^2,1 „Entrez Gene: elastin”.
↑ „Elastin (ELN)”. Arhivirano iz originala na datum 2017-03-13. Pristupljeno 31. 10. 2011.
↑ Lisa D Muiznieks, Anthony S Weiss and Fred W Keeley (2010). „Structural disorder and dynamics of elastin.”. Biochem Cell Biol 88 (2): 239–50. DOI:10.1139/o09-161. PMID 20453927.

Literatura

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Keeley FW, Bellingham CM, Woodhouse KA (2002). „Elastin as a self-organizing biomaterial: use of recombinantly expressed human elastin polypeptides as a model for investigations of structure and self-assembly of elastin”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 357 (1418): 185–9. DOI:10.1098/rstb.2001.1027. PMC 1692930. PMID 11911775.
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