Interleukin 11
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| Interleukin 11 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | IL11; AGIF; IL-11 | ||||||||||
| Vanjski ID | OMIM: 147681 MGI: 107613 HomoloGene: 535 GeneCards: IL11 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 3589 | 16156 | |||||||||
| Ensembl | ENSG00000095752 | ENSMUSG00000004371 | |||||||||
| UniProt | P20809 | Q3V0U3 | |||||||||
| Ref. Sekv. (iRNK) | NM_000641 | NM_008350 | |||||||||
| Ref. Sekv. (protein) | NP_000632 | NP_032376 | |||||||||
| Lokacija (UCSC) | Chr 19: 60.57 - 60.57 Mb | Chr 7: 4.38 - 4.38 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Interleukin 11 (IL-11) je protein koji je kod ljudi kodiran IL11 genom.[1][2]
IL-11 je multifunkcionalni citokin koji je prvo izolovan 1990. godine iz kičmene moždine-izvedenih stromalnih ćelija. On je ključni regulator of više evenata hematopoeze, pogotovu stimulacije sazrevanja megakariocita.[3] On je isto poznat pod imenima inhibitorni faktor adipogeneze (AGIF)[4] i oprelvekin.
U poređenju sa drugim interleukinima, IL-11 je relativno slabo karakterisan.
Struktura
LJudski IL-11 gen, koji sadrži 5 eksona i 4 introna, je lociran na hromozomu 19,[1] i kodira 23 kDa protein. IL-11 is je član IL-6 citokinske familije, koja je osobena po upotrebi zajedničkog koreceptora gp130. Signal specifičnost daje IL-11R alfa podjedinica.
Signalizacija
Prenos signala se inicira nakon IL-11 vezivanja za IL-11R alfa i gp130, što omogućava homodimerizaciju gp130 molekula. Ovo omogućava gp130-asociranoj JAK kinazi da se aktivira i da fosforiliše intracelularne tirozinove ostatke na gp130.[5][6]
Funkcija
Za IL-11 je bilo pokazano da poboljšava oporavak trombocita nakon hemoterapijom-uzrokovane trombocitopenije, inducira akutnu fazu proteina, modulira antigen-antitelo odziv, učestvuje u regulaciji proliferacije i diferencijacije koštanih ćelija, i možda može biti korišćen kao terapeutik za osteoporozu. IL-11 stimuliše rast određenih limfocita, i u modelu na glodarima, stimuliše povećanje kortikalne debljine i jačanje dugačkih kostiju. Pored toga što ima limfopoetske/hematopoetske i osteotrofske osobine, on funkcioniše u mnogim drugim tkivima, uključujući mozak, creva i testise.
Reference
- ↑ 1,0 1,1 McKinley D, Wu Q, Yang-Feng T, Yang YC (1992). „Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)”. Genomics 13 (3): 814–9. DOI:10.1016/0888-7543(92)90158-O. PMID 1386338.
- ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
- ↑ Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara RM, Leary AC, Sibley B, Clark SC, Williams DA (1990). „Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine”. Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7512–6. DOI:10.1073/pnas.87.19.7512. PMID 2145578.
- ↑ Kawashima I, Ohsumi J, Mita-Honjo K, Shimoda-Takano K, Ishikawa H, Sakakibara S, Miyadai K, Takiguchi Y (1991). „Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11”. FEBS Lett. 283 (2): 199–202. DOI:10.1016/0014-5793(91)80587-S. PMID 1828438.
- ↑ Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F (August 2003). „Principles of interleukin (IL)-6-type cytokine signalling and its regulation”. Biochem. J. 374 (Pt 1): 1–20. DOI:10.1042/BJ20030407. PMC 1223585. PMID 12773095.
- ↑ Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4.
Literatura
- Yang YC, Yin T (1993). „Interleukin-11 and its receptor.”. Biofactors 4 (1): 15–21. PMID 1292471.
- Bhatia M, Davenport V, Cairo MS (2007). „The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors, lymphoma, acute myeloid leukemia and bone marrow failure syndromes.”. Leuk. Lymphoma 48 (1): 9–15. DOI:10.1080/10428190600909115. PMID 17325843.
- McKinley D, Wu Q, Yang-Feng T, Yang YC (1992). „Genomic sequence and chromosomal location of human interleukin-11 gene (IL11).”. Genomics 13 (3): 814–9. DOI:10.1016/0888-7543(92)90158-O. PMID 1386338.
- Kawashima I, Ohsumi J, Mita-Honjo K, et al. (1991). „Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11.”. FEBS Lett. 283 (2): 199–202. DOI:10.1016/0014-5793(91)80587-S. PMID 1828438.
- Paul SR, Bennett F, Calvetti JA, et al. (1990). „Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.”. Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7512–6. DOI:10.1073/pnas.87.19.7512. PMID 2145578.
- Wang XY, Fuhrer DK, Marshall MS, Yang YC (1996). „Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells.”. J. Biol. Chem. 270 (47): 27999–8002. PMID 7499280.
- Chérel M, Sorel M, Lebeau B, et al. (1995). „Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11.”. Blood 86 (7): 2534–40. PMID 7670098.
- Yamaguchi M, Miki N, Ono M, et al. (1995). „Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer.”. Endocrinology 136 (3): 1072–8. DOI:10.1210/en.136.3.1072. PMID 7867561.
- Mehler MF, Rozental R, Dougherty M, et al. (1993). „Cytokine regulation of neuronal differentiation of hippocampal progenitor cells.”. Nature 362 (6415): 62–5. DOI:10.1038/362062a0. PMID 8383296.
- Morris JC, Neben S, Bennett F, et al. (1996). „Molecular cloning and characterization of murine interleukin-11.”. Exp. Hematol. 24 (12): 1369–76. PMID 8913282.
- Neddermann P, Graziani R, Ciliberto G, Paonessa G (1997). „Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130.”. J. Biol. Chem. 271 (48): 30986–91. DOI:10.1074/jbc.271.48.30986. PMID 8940087.
- Barton VA, Hudson KR, Heath JK (1999). „Identification of three distinct receptor binding sites of murine interleukin-11.”. J. Biol. Chem. 274 (9): 5755–61. DOI:10.1074/jbc.274.9.5755. PMID 10026196.
- Tacken I, Dahmen H, Boisteau O, et al. (1999). „Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis.”. Eur. J. Biochem. 265 (2): 645–55. DOI:10.1046/j.1432-1327.1999.00755.x. PMID 10504396.
- Mahboubi K, Biedermann BC, Carroll JM, Pober JS (2000). „IL-11 activates human endothelial cells to resist immune-mediated injury.”. J. Immunol. 164 (7): 3837–46. PMID 10725745.
- Barton VA, Hall MA, Hudson KR, Heath JK (2000). „Interleukin-11 signals through the formation of a hexameric receptor complex.”. J. Biol. Chem. 275 (46): 36197–203. DOI:10.1074/jbc.M004648200. PMID 10948192.
- Curti A, Tafuri A, Ricciardi MR, et al. (2002). „Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1).”. Haematologica 87 (4): 373–80. PMID 11940481.
- Van der Meeren A, Mouthon MA, Gaugler MH, et al. (2002). „Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: interactive effect with thrombopoietin.”. Radiat. Res. 157 (6): 642–9. DOI:10.1667/0033-7587(2002)157[0642:AORHIA]2.0.CO;2. PMID 12005542.
- McCloy MP, Roberts IA, Howarth LJ, et al. (2002). „Interleukin-11 levels in healthy and thrombocytopenic neonates.”. Pediatr. Res. 51 (6): 756–60. PMID 12032273.
- Bartz H, Büning-Pfaue F, Türkel O, Schauer U (2002). „Respiratory syncytial virus induces prostaglandin E2, IL-10 and IL-11 generation in antigen presenting cells.”. Clin. Exp. Immunol. 129 (3): 438–45. DOI:10.1046/j.1365-2249.2002.01927.x. PMID 12197884.
Spoljašnje veze
- MeSH Interleukin-11
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