Kristalografska struktura kalcineurinskog heterodimera formirana od katalitičke (PPP3CA) i regulatorne (PPP3R1) podjedinice.[1]
Kalcineurin (CN) je proteinska fosfataza, takođe poznata kao proteinska fosfataza 3, i kalcijum-zavisna serin-treoninska fosfataza.[2]. On aktivira T ćelije imunskog sistema, i može se blokirati lekovima. Kalcineurin aktivira nuklearni faktor aktiviranih T ćelija, citoplazmni (NFATc) transkripcioni faktor, putem njegove defosforilacije. Aktivirani NFATc se zatim translocira u jedro, gde povećava izražavanje interleukina 2 (IL-2), koji zatim stimuliše rast i diferencijaciju T ćelijskog responsa. Kalcineurin je biološki cilj klase lekova pod nazivom kalcineurinski inhibitori, koja obuhvata ciklosporin, pimekrolimus i takrolimus.
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1Struktura
2Reference
3Literatura
4Vidi još
5Spoljašnje veze
Struktura
Kalcineurin je heterodimer od 61-kD kalmodulin-vezujuće katalitičke podjedinice, kalcineurina A i 19-kD Ca2+-vezujuće regulatorne podjedinice, kalcineurina B. Postoje tri izozima katalitčke podjedinice, svaka od kojih je kodirana zasebnim genom (PPP3CA, PPP3CB, i PPP3CC) i dve regulatorne izoforme, takođe kodirane zasebnim genima (PPP3R1, PPP3R2).
↑PDB 1AUI; Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW (December 1995). „Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex”. Nature378 (6557): 641–4. DOI:10.1038/378641a0. PMID 8524402.
↑Liu L, Zhang J, Yuan J, Dang Y, Yang C, Chen X, Xu J, Yu L. (March 2005). „Crystal Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis”. Mol Biol Rep32 (1): 41–45. DOI:10.1007/s11033-004-4250-4. PMID 15865209.
Literatura
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