Prostaglandinski E2 receptor

Prostaglandinski E receptor 2
Identifikatori
Simboli PTGER2; EP2
Vanjski ID OMIM: 176804 MGI: 97794 HomoloGene: 739 IUPHAR: EP2 GeneCards: PTGER2 Gene
Ontologija gena
Molekularna funkcija • aktivnost prostaglandinskog E receptora
Celularna komponenta • ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • signalni put G-protein spregnutog receptora
• signalni put adenilat ciklazom aktiviranog G-protein spregnutog receptora
• respons na lipopolisaharid
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5732 19217
Ensembl ENSG00000125384 ENSMUSG00000037759
UniProt P43116 Q62053
RefSeq (mRNA) NM_000956.3 NM_008964.4
RefSeq (protein) NP_000947.2 NP_032990.1
Lokacija (UCSC) Chr 14:
52.78 - 52.8 Mb		 Chr 14:
45.61 - 45.62 Mb
PubMed pretraga [1] [2]

Prostaglandinski E2 receptor (EP2) je prostaglandinski receptor za prostaglandin E2. On je kodiran ljudskim genom PTGER2.[1]

On je povezan sa aspirinom indukovanom astmom.[2]

Mehanizam

Ovaj protein je G protein spregnuti receptor, koji aktivira G protein Gs.[3]

Reference

  1. ^ „Entrez Gene: PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa”. 
  2. ^ Jinnai N; Sakagami T; Sekigawa T; et al. (2004). „Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach”. Hum. Mol. Genet. 13 (24): 3203—17. PMID 15496426. doi:10.1093/hmg/ddh332. CS1 одржавање: Експлицитна употреба et al. (веза)
  3. ^ Invitrogen Online Ordering: Prostanoid Receptor PTGER2 Assays[мртва веза]

Literatura

  • Duncan AM; Anderson LL; Funk CD; et al. (1995). „Chromosomal localization of the human prostanoid receptor gene family.”. Genomics. 25 (3): 740—2. PMID 7759114. doi:10.1016/0888-7543(95)80022-E. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Regan JW; Bailey TJ; Pepperl DJ; et al. (1994). „Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype.”. Mol. Pharmacol. 46 (2): 213—20. PMID 8078484. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Bastien L; Sawyer N; Grygorczyk R; et al. (1994). „Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.”. J. Biol. Chem. 269 (16): 11873—7. PMID 8163486. CS1 одржавање: Експлицитна употреба et al. (веза)
  • An S, Yang J, Xia M, Goetzl EJ (1994). „Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2.”. Biochem. Biophys. Res. Commun. 197 (1): 263—70. PMID 8250933. doi:10.1006/bbrc.1993.2470. 
  • Stillman BA, Breyer MD, Breyer RM (1999). „Importance of the extracellular domain for prostaglandin EP(2) receptor function.”. Mol. Pharmacol. 56 (3): 545—51. PMID 10462542. 
  • Smock SL; Pan LC; Castleberry TA; et al. (1999). „Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype.”. Gene. 237 (2): 393—402. PMID 10521663. doi:10.1016/S0378-1119(99)00323-6. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Desai S, April H, Nwaneshiudu C, Ashby B (2001). „Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration.”. Mol. Pharmacol. 58 (6): 1279—86. PMID 11093764. 
  • Duckworth N, Marshall K, Clayton JK (2002). „An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women.”. J. Endocrinol. 172 (2): 263—9. PMID 11834444. doi:10.1677/joe.0.1720263. 
  • Kyveris A, Maruscak E, Senchyna M (2002). „Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.”. Mol. Vis. 8: 51—8. PMID 11951086. 
  • Takafuji VA, Evans A, Lynch KR, Roche JK (2003). „PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer.”. Prostaglandins Leukot. Essent. Fatty Acids. 66 (1): 71—81. PMID 12051958. doi:10.1054/plef.2001.0299. 
  • Scandella E; Men Y; Gillessen S; et al. (2002). „Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.”. Blood. 100 (4): 1354—61. PMID 12149218. doi:10.1182/blood-2001-11-0017. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Okuyama T; Ishihara S; Sato H; et al. (2002). „Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines.”. J. Lab. Clin. Med. 140 (2): 92—102. PMID 12228765. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Konger RL; Scott GA; Landt Y; et al. (2003). „Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression.”. Am. J. Pathol. 161 (6): 2065—78. PMC 1850902 Слободан приступ. PMID 12466123. doi:10.1016/S0002-9440(10)64485-9. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Abulencia JP; Gaspard R; Healy ZR; et al. (2003). „Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells”. J. Biol. Chem. 278 (31): 28388—94. PMID 12743126. doi:10.1074/jbc.M301378200. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Richards JA, Brueggemeier RW (2003). „Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes”. J. Clin. Endocrinol. Metab. 88 (6): 2810—6. PMID 12788892. doi:10.1210/jc.2002-021475. 
  • Sun HS; Hsiao KY; Hsu CC; et al. (2003). „Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor”. Endocrinology. 144 (9): 3934—42. PMID 12933667. doi:10.1210/en.2003-0289. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Bradbury DA; Newton R; Zhu YM; et al. (2004). „Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors”. J. Biol. Chem. 278 (50): 49954—64. PMID 14517215. doi:10.1074/jbc.M307964200. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Moreland RB; Kim N; Nehra A; et al. (2004). „Functional prostaglandin E (EP) receptors in human penile corpus cavernosum”. Int. J. Impot. Res. 15 (5): 362—8. PMID 14562138. doi:10.1038/sj.ijir.3901042. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Sugimoto Y; Nakato T; Kita A; et al. (2004). „A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors”. J. Biol. Chem. 279 (12): 11016—26. PMID 14699136. doi:10.1074/jbc.M307404200. CS1 одржавање: Експлицитна употреба et al. (веза)

Vidi još

Spoljašnje veze

  • „Prostanoid Receptor: EP2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г. 
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Klasa A: Rodopsinu slični
Neurotransmiter
Adrenergički
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
Eikozanoidni
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
Neuropeptidni
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
Orfan
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
Orfan
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
Ukus
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni