BAMBI

Protein-coding gene in the species Homo sapiens
BAMBI
Identifiers
AliasesBAMBI, NMA, BMP and activin membrane-bound inhibitor, BMP and activin membrane bound inhibitor
External IDsOMIM: 604444 MGI: 1915260 HomoloGene: 8215 GeneCards: BAMBI
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for BAMBI
Genomic location for BAMBI
Band10p12.1Start28,677,510 bp[1]
End28,682,932 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for BAMBI
Genomic location for BAMBI
Band18|18 A1Start3,507,923 bp[2]
End3,516,404 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • periodontal fiber

  • glomerulus

  • adrenal cortex

  • left adrenal gland

  • metanephric glomerulus

  • ascending aorta

  • placenta

  • seminal vesicula

  • urinary bladder
Top expressed in
  • molar

  • endocardial cushion

  • Meckel's cartilage

  • clavicle

  • hair follicle

  • upper lip

  • atrioventricular valve

  • body of femur

  • crypt of lieberkuhn of small intestine

  • abdominal wall
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • type II transforming growth factor beta receptor binding
  • frizzled binding
Cellular component
  • cytoplasm
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • positive regulation of transcription, DNA-templated
  • positive regulation of protein binding
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • cell migration
  • positive regulation of epithelial to mesenchymal transition
  • positive regulation of cell population proliferation
  • regulation of cell shape
  • positive regulation of canonical Wnt signaling pathway
  • transforming growth factor beta receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25805

68010

Ensembl

ENSG00000095739

ENSMUSG00000024232

UniProt

Q13145

Q9D0L6

RefSeq (mRNA)

NM_012342

NM_026505

RefSeq (protein)

NP_036474

NP_080781

Location (UCSC)Chr 10: 28.68 – 28.68 MbChr 18: 3.51 – 3.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.[5][6]

Function

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000095739 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024232 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)".
  6. ^ Degen WG, Weterman MA, van Groningen JJ, Cornelissen IM, Lemmers JP, Agterbos MA, Geurts van Kessel A, Swart GW, Bloemers HP (February 1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer. 65 (4): 460–5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228.

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Lin Z, Gao C, Ning Y, et al. (2008). "The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling". J. Biol. Chem. 283 (48): 33053–8. doi:10.1074/jbc.M804039200. PMC 2662247. PMID 18838381.
  • Sekiya T, Oda T, Matsuura K, Akiyama T (2004). "Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling". Biochem. Biophys. Res. Commun. 320 (3): 680–4. doi:10.1016/j.bbrc.2004.06.017. PMID 15240101.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Fritzmann J, Morkel M, Besser D, et al. (2009). "A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential". Gastroenterology. 137 (1): 165–75. doi:10.1053/j.gastro.2009.03.041. PMID 19328798.
  • Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
  • Khin SS, Kitazawa R, Win N, et al. (2009). "BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer". Int. J. Cancer. 125 (2): 328–38. doi:10.1002/ijc.24318. PMID 19326429. S2CID 32084443.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Sekiya T, Adachi S, Kohu K, et al. (2004). "Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells". J. Biol. Chem. 279 (8): 6840–6. doi:10.1074/jbc.M310876200. PMID 14660579.
  • Togo N, Ohwada S, Sakurai S, et al. (2008). "Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer". World J. Gastroenterol. 14 (31): 4880–8. doi:10.3748/wjg.14.4880. PMC 2739940. PMID 18756595.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Zhang Z, Henzel WJ (2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Degen WG, Weterman MA, van Groningen JJ, et al. (1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer. 65 (4): 460–5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
TGF beta superfamily of ligands
Ligand of ACVR or TGFBR
Ligand of BMPR
TGF beta receptors
(Activin, BMP, family)
TGFBR1:
TGFBR2:
TGFBR3:
Transducers/SMADLigand inhibitors
Coreceptors
Other
  • v
  • t
  • e
TGFβ receptor superfamily modulators
Type I
ALK1 (ACVRL1)
  • Kinase inhibitors: K-02288
  • ML-347 (LDN-193719, VU0469381)
  • Other inhibitors: Disitertide
ALK2 (ACVR1A)
  • Kinase inhibitors: DMH-1
  • DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
  • ML-347 (LDN-193719, VU0469381)
ALK3 (BMPR1A)
  • Kinase inhibitors: DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
ALK4 (ACVR1B)
  • Kinase inhibitors: A 83-01
  • SB-431542
  • SB-505124
ALK5 (TGFβR1)
ALK6 (BMPR1B)
  • Kinase inhibitors: DMH-2
  • Dorsomorphin (BML-275)
  • K-02288
ALK7 (ACVR1C)
  • Antagonists: Lefty (1, 2)
  • Kinase inhibitors: A 83-01
  • SB-431542
  • SB-505124
Type II
TGFβR2
  • Kinase inhibitors: DMH-2
  • LY-364947
BMPR2
ACVR2A (ACVR2)
ACVR2B
  • Decoy receptors: Ramatercept
AMHR2 (AMHR)
Type III
TGFβR3 (β-glycan)
Unsorted


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