CHRNB4

Protein-coding gene in the species Homo sapiens
CHRNB4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2ASG

Identifiers
AliasesCHRNB4, cholinergic receptor nicotinic beta 4 subunit
External IDsOMIM: 118509; MGI: 87892; HomoloGene: 20196; GeneCards: CHRNB4; OMA:CHRNB4 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for CHRNB4
Genomic location for CHRNB4
Band15q25.1Start78,624,111 bp[1]
End78,727,754 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for CHRNB4
Genomic location for CHRNB4
Band9|9 BStart54,935,438 bp[2]
End54,956,063 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • sural nerve

  • right adrenal gland

  • appendix

  • thymus

  • lymph node

  • rectum

  • smooth muscle tissue

  • islet of Langerhans

  • transverse colon
Top expressed in
  • habenula

  • pineal gland

  • ciliary body

  • pretectal area

  • iris

  • Paneth cell

  • adrenal gland

  • carotid body

  • lens

  • ileum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • acetylcholine binding
  • acetylcholine receptor activity
  • ion channel activity
  • ligand-gated ion channel activity
  • protein heterodimerization activity
  • extracellular ligand-gated ion channel activity
  • protein binding
  • acetylcholine-gated cation-selective channel activity
  • transmembrane signaling receptor activity
  • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Cellular component
  • acetylcholine-gated channel complex
  • integral component of membrane
  • postsynaptic membrane
  • membrane
  • plasma membrane
  • synapse
  • integral component of plasma membrane
  • cell junction
  • neuron projection
  • specific granule membrane
  • tertiary granule membrane
  • cholinergic synapse
Biological process
  • smooth muscle contraction
  • locomotory behavior
  • regulation of smooth muscle contraction
  • protein heterooligomerization
  • positive regulation of transmission of nerve impulse
  • regulation of membrane potential
  • response to nicotine
  • synaptic transmission, cholinergic
  • ion transport
  • regulation of neurotransmitter secretion
  • behavioral response to nicotine
  • synaptic transmission involved in micturition
  • action potential
  • signal transduction
  • neutrophil degranulation
  • regulation of postsynaptic membrane potential
  • excitatory postsynaptic potential
  • ion transmembrane transport
  • chemical synaptic transmission
  • neuromuscular synaptic transmission
  • nervous system process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1143

108015

Ensembl

ENSG00000117971

ENSMUSG00000035200

UniProt

P30926

Q8R493

RefSeq (mRNA)

NM_000750
NM_001256567

NM_148944

RefSeq (protein)

NP_000741
NP_001243496

NP_683746

Location (UCSC)Chr 15: 78.62 – 78.73 MbChr 9: 54.94 – 54.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal acetylcholine receptor subunit beta-4 is a protein that in humans is encoded by the CHRNB4 gene.[5][6]


Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. [§ 1]

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NicotineActivityonChromaffinCells_WP1603Go to articlego to articleGo to articleGo to articleGo to articleGo to articlego to articlego to articleGo to articleGo to articlego to articleGo to articleGo to article
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NicotineActivityonChromaffinCells_WP1603Go to articlego to articleGo to articleGo to articleGo to articleGo to articlego to articlego to articleGo to articleGo to articlego to articleGo to articleGo to article
|alt=Nicotine Activity on Chromaffin Cells edit]]
Nicotine Activity on Chromaffin Cells edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineActivityonChromaffinCells_WP1603".

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117971 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035200 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–282. doi:10.1016/0888-7543(91)90253-B. PMID 2004777.
  6. ^ "Entrez Gene: CHRNB4 cholinergic receptor, nicotinic, beta 4".

Further reading

  • Green WN, Millar NS (1995). "Ion-channel assembly". Trends Neurosci. 18 (6): 280–287. doi:10.1016/0166-2236(95)93915-K. PMID 7571003.
  • Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 147: 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266.
  • Tarroni P, Rubboli F, Chini B, et al. (1992). "Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines". FEBS Lett. 312 (1): 66–70. doi:10.1016/0014-5793(92)81411-E. PMID 1330682.
  • Anand R, Lindstrom J (1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–967. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
  • Raimondi E, Rubboli F, Moralli D, et al. (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits". Genomics. 12 (4): 849–50. doi:10.1016/0888-7543(92)90324-L. PMID 1572664.
  • Boulter J, O'Shea-Greenfield A, Duvoisin RM, et al. (1990). "Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster". J. Biol. Chem. 265 (8): 4472–82. doi:10.1016/S0021-9258(19)39588-2. PMID 1689727.
  • Papke RL, Heinemann SF (1992). "The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors". J. Physiol. 440: 95–112. doi:10.1113/jphysiol.1991.sp018698. PMC 1180142. PMID 1725184.
  • Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–228. doi:10.1007/BF02736842. PMID 8906617. S2CID 45737923.
  • Chavez-Noriega LE, Crona JH, Washburn MS, et al. (1997). "Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes". J. Pharmacol. Exp. Ther. 280 (1): 346–56. PMID 8996215.
  • Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–314. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220.
  • Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.
  • Gerzanich V, Kuryatov A, Anand R, Lindstrom J (1997). ""Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor". Mol. Pharmacol. 51 (2): 320–7. doi:10.1124/mol.51.2.320. PMID 9203638.
  • Gerzanich V, Wang F, Kuryatov A, Lindstrom J (1998). "alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors". J. Pharmacol. Exp. Ther. 286 (1): 311–20. PMID 9655874.
  • Hellström-Lindahl E, Gorbounova O, Seiger A, et al. (1998). "Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord". Brain Res. Dev. Brain Res. 108 (1–2): 147–160. doi:10.1016/S0165-3806(98)00046-7. PMID 9693793.
  • Sato KZ, Fujii T, Watanabe Y, et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173. S2CID 43548155.
  • Boorman JP, Groot-Kormelink PJ, Sivilotti LG (2001). "Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes". J. Physiol. 529 (3): 565–77. doi:10.1111/j.1469-7793.2000.00565.x. PMC 2270211. PMID 11118490.
  • Lev-Lehman E, Bercovich D, Xu W, et al. (2001). "Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4". J. Hum. Genet. 46 (7): 362–366. doi:10.1007/PL00010921. PMID 11450844.
  • Groot-Kormelink PJ, Boorman JP, Sivilotti LG (2001). "Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach". Br. J. Pharmacol. 134 (4): 789–796. doi:10.1038/sj.bjp.0704313. PMC 1573006. PMID 11606319.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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