Protein-coding gene in the species Homo sapiens
| GJA10 |
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| Identifiers |
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| Aliases | GJA10, CX62, gap junction protein alpha 10 |
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| External IDs | OMIM: 611924 MGI: 1339969 HomoloGene: 7733 GeneCards: GJA10 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 6 (human)[1] |
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| | Band | 6q15 | Start | 89,894,469 bp[1] |
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| End | 89,921,760 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 4 (mouse)[2] |
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| | Band | 4 A5|4 14.25 cM | Start | 32,596,960 bp[2] |
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| End | 32,602,760 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| | Top expressed in | - secondary oocyte
- Region I of hippocampus proper
- gland
- adipose tissue
- endocrine gland
- white adipose tissue
- haematopoietic system
- thymus
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - gap junction channel activity
| | Cellular component | - integral component of membrane
- gap junction
- cell junction
- plasma membrane
- connexin complex
- membrane
| | Biological process | - synapse assembly
- cell communication
- gamete generation
- transmembrane transport
- response to light stimulus
- detection of light stimulus involved in visual perception
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | |
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ENSG00000135355
ENSG00000288435 |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 6: 89.89 – 89.92 Mb | Chr 4: 32.6 – 32.6 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Gap junction alpha-10 protein, also known as connexin-62 (Cx62), is a protein that in humans is encoded by the GJA10 gene.[5]
Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.[5][6]
References
- ^ a b c ENSG00000288435 GRCh38: Ensembl release 89: ENSG00000135355, ENSG00000288435 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051056 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: gap junction protein".
- ^ Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.
Further reading
- Hosgood HD, Zhang L, Shen M, et al. (2009). "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med. 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC 2928224. PMID 19773279.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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