HCN3

Protein-coding gene in the species Homo sapiens
HCN3
Identifiers
AliasesHCN3, hyperpolarization activated cyclic nucleotide gated potassium channel 3
External IDsOMIM: 609973; MGI: 1298211; HomoloGene: 22453; GeneCards: HCN3; OMA:HCN3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HCN3
Genomic location for HCN3
Band1q22Start155,277,463 bp[1]
End155,289,848 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for HCN3
Genomic location for HCN3
Band3|3 F1Start89,053,381 bp[2]
End89,067,503 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • testicle

  • ganglionic eminence

  • mucosa of transverse colon

  • ventricular zone

  • pituitary gland

  • anterior pituitary

  • hypothalamus

  • superior frontal gyrus

  • right frontal lobe
Top expressed in
  • neural layer of retina

  • perirhinal cortex

  • entorhinal cortex

  • pineal gland

  • barrel cortex

  • CA3 field

  • spinal ganglia

  • glossopharyngeal ganglion

  • olfactory bulb

  • choroid plexus of fourth ventricle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • potassium channel activity
  • cAMP binding
  • sodium channel activity
  • voltage-gated ion channel activity
  • ion channel activity
  • voltage-gated potassium channel activity
  • voltage-gated sodium channel activity
  • protein binding
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • synapse
  • neuronal cell body
  • axon
  • dendrite
  • cone cell pedicle
  • integral component of plasma membrane
Biological process
  • sodium ion transmembrane transport
  • sodium ion transport
  • cellular response to dopamine
  • regulation of membrane potential
  • regulation of ion transmembrane transport
  • ion transport
  • potassium ion transport
  • response to cisplatin
  • transmembrane transport
  • potassium ion transmembrane transport
  • cellular response to cAMP
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57657

15168

Ensembl

ENSG00000143630
ENSG00000263324

ENSMUSG00000028051

UniProt

Q9P1Z3

O88705

RefSeq (mRNA)

NM_020897

NM_008227

RefSeq (protein)

NP_065948

NP_032253

Location (UCSC)Chr 1: 155.28 – 155.29 MbChr 3: 89.05 – 89.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is a protein that in humans is encoded by the HCN3 gene.[5][6]

See also

References

  1. ^ a b c ENSG00000263324 GRCh38: Ensembl release 89: ENSG00000143630, ENSG00000263324 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028051 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
  6. ^ "Entrez Gene: HCN3 hyperpolarization activated cyclic nucleotide-gated potassium channel 3".

Further reading

  • Santoro B, Grant SG, Bartsch D, Kandel ER (1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14815–20. Bibcode:1997PNAS...9414815S. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
  • Ludwig A, Zong X, Jeglitsch M, et al. (1998). "A family of hyperpolarization-activated mammalian cation channels". Nature. 393 (6685): 587–91. Bibcode:1998Natur.393..587L. doi:10.1038/31255. PMID 9634236. S2CID 4429453.
  • Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Much B, Wahl-Schott C, Zong X, et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". J. Biol. Chem. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Stieber J, Stöckl G, Herrmann S, et al. (2005). "Functional expression of the human HCN3 channel". J. Biol. Chem. 280 (41): 34635–43. doi:10.1074/jbc.M502508200. PMID 16043489.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl−: Chloride channel
H+: Proton channel
M+: CNG cation channel
M+: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders


Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e