UBE2H

Protein-coding gene in the species Homo sapiens
UBE2H
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2Z5D

Identifiers
AliasesUBE2H, E2-20K, GID3, UBC8, UBCH, UBCH2, ubiquitin conjugating enzyme E2 H
External IDsOMIM: 601082; MGI: 104632; HomoloGene: 103894; GeneCards: UBE2H; OMA:UBE2H - orthologs
EC number2.3.2.24
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for UBE2H
Genomic location for UBE2H
Band7q32.2Start129,830,732 bp[1]
End129,952,960 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for UBE2H
Genomic location for UBE2H
Band6 A3.3|6 12.52 cMStart30,211,288 bp[2]
End30,304,538 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • right adrenal cortex

  • epithelium of colon

  • saphenous vein

  • internal globus pallidus

  • Skeletal muscle tissue of biceps brachii

  • amniotic fluid

  • islet of Langerhans

  • left adrenal gland

  • caput epididymis
Top expressed in
  • blood

  • retinal pigment epithelium

  • Rostral migratory stream

  • tibiofemoral joint

  • substantia nigra

  • medullary collecting duct

  • ascending aorta

  • ciliary body

  • condyle

  • fossa
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein binding
  • ATP binding
  • ubiquitin conjugating enzyme activity
  • ubiquitin protein ligase binding
  • ubiquitin protein ligase activity
  • ubiquitin-protein transferase activity
Cellular component
  • cytoplasm
  • cytosol
Biological process
  • protein K48-linked ubiquitination
  • ubiquitin-dependent protein catabolic process
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • protein K11-linked ubiquitination
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7328

22214

Ensembl

ENSG00000186591

ENSMUSG00000039159

UniProt

P62256

P62257

RefSeq (mRNA)

NM_001202498
NM_003344
NM_182697

NM_001169576
NM_001169577
NM_009459

RefSeq (protein)

NP_001189427
NP_003335
NP_874356
NP_003335.1

NP_001163047
NP_001163048
NP_033485

Location (UCSC)Chr 7: 129.83 – 129.95 MbChr 6: 30.21 – 30.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186591 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039159 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R (Apr 1994). "A human ubiquitin-conjugating enzyme homologous to yeast UBC8". J Biol Chem. 269 (12): 8797–802. doi:10.1016/S0021-9258(17)37039-4. PMID 8132613.
  6. ^ a b "Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)".

Further reading

  • Wefes I, Mastrandrea LD, Haldeman M, et al. (1995). "Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation". Proc. Natl. Acad. Sci. U.S.A. 92 (11): 4982–6. Bibcode:1995PNAS...92.4982W. doi:10.1073/pnas.92.11.4982. PMC 41831. PMID 7761435.
  • Kaiser P, Mandl S, Schweiger M, Schneider R (1996). "Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2". FEBS Lett. 377 (2): 193–6. Bibcode:1995FEBSL.377..193K. doi:10.1016/0014-5793(95)01323-7. PMID 8543049. S2CID 24431321.
  • Hayashida S, Yamasaki K, Asada Y, et al. (2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948. S2CID 19637860.
  • Vourc'h P, Martin I, Bonnet-Brilhault F, et al. (2005). "Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder". Psychiatr. Genet. 13 (4): 221–5. doi:10.1097/00041444-200312000-00005. PMID 14639049. S2CID 25469223.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
  • Bartee E, Mansouri M, Hovey Nerenberg BT, et al. (2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J. Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
  • Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846. S2CID 39773935.
  • Kim HJ, Chong KH, Kang SW, et al. (2005). "Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening". Immunol. Lett. 95 (2): 155–9. doi:10.1016/j.imlet.2004.07.001. PMID 15388255.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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Chaperones/
protein folding
Heat shock proteins/
Chaperonins
Other
Protein targeting
Ubiquitin
(ubiquitylation)
Ubiquitin-like proteins
(UBL)
SUMO protein
(SUMOylation)
  • E1 SUMO-activating enzyme
  • E2 SUMO-conjugating enzyme
Other


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