Gastrin-oslobađajući peptidni receptor

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Gastrin-oslobađajući peptidni receptor
Identifikatori
SimboliGRPR;
Vanjski IDOMIM: 305670 MGI: 95836 HomoloGene: 21098 IUPHAR: BB2 GeneCards: GRPR Gene
Ontologija gena
Molekularna funkcija • receptorska aktivnost
• aktivnost bombezinskog receptora
• aktivnost peptidnog receptora, G-protein spregnutog
Celularna komponenta • ćelijska membrana
• integralno sa ćelijskom membranom
• integralno sa membranom
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• regulacija ćelijske proliferacije
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez292514829
EnsemblENSG00000126010ENSMUSG00000031364
UniProtP30550Q53WV4
RefSeq (mRNA)NM_005314NM_008177
RefSeq (protein)NP_005305NP_032203
Lokacija (UCSC)Chr X:
16.05 - 16.08 Mb		Chr X:
158.86 - 158.89 Mb
PubMed pretraga[1][2]

Gastrin-oslobađajući peptidni receptor (GRPR), ili BB2 [1] je G protein-spregnuti receptor čije endogeni ligand je gastrin oslobađajući peptid.[2] Kod ljudi on je visoko izražen u pankreasu, a takođe i u želucu, adrenalnom korteksu i mozgu.[3]

Gastrin-oslobađajući peptid (GRP) reguliše brojne funkcije gastrointestinalnog i centralnog nervnog sistema, koje obuhvataju oslobađanje gastrointestinalnih hormona, kontrakcije glatkih mišića, proliferaciju epitelnih ćelija i koji je potentan mitogen neoplastičnog tkiva. GRP dejstvo je posredovano kroz gastrin-oslobađajući peptidni receptor. Ovaj receptor je glikozilirani, 7-transmembranski G-protein spregnuti receptor koji aktivira signalni put fosfolipaze C. Ovaj receptor je aberantno izražen u brojnim tipovima raka, kao što je rak pluća, debelog creva, i prostate.[4]

Transkripcioni faktor CREB je regulator humane GRP-R ekspresije kod raka debelog creva.[5]

Literatura

  1. ↑ „Bombesin Receptors: BB2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
  2. ↑ Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). „Expression and characterization of cloned human bombesin receptors”. Mol. Pharmacol. 47 (1): 10–20. PMID 7838118. Arhivirano iz originala na datum 2008-09-06. Pristupljeno 2014-05-08. 
  3. ↑ Corjay MH, Dobrzanski DJ, Way JM, Viallet J, Shapira H, Worland P, Sausville EA and Battey JF (1991). „Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.”. J. Biol. Chem. 266 (28): 18771–18779. PMID 1655761. 
  4. ↑ „Entrez Gene: GRPR gastrin-releasing peptide receptor”. 
  5. ↑ Chinnappan D, Qu X, Xiao D, Ratnasari A, Weber HC (May 2008). „Human gastrin releasing peptide receptor gene regulation requires transcription factor binding at two distinct cre sites”. Am. J. Physiol. Gastrointest. Liver Physiol. 295 (1): G153. DOI:10.1152/ajpgi.00036.2008. PMC 2494719. PMID 18483184. 

Dodatna literatura

  • Corjay MH, Dobrzanski DJ, Way JM, et al. (1991). „Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.”. J. Biol. Chem. 266 (28): 18771–9. PMID 1655761. 
  • Alitalo T, Francis F, Kere J, et al. (1995). „A 6-Mb YAC contig in Xp22.1-p22.2 spanning the DXS69E, XE59, GLRA2, PIGA, GRPR, CALB3, and PHKA2 genes.”. Genomics 25 (3): 691–700. DOI:10.1016/0888-7543(95)80012-B. PMID 7759104. 
  • Benya RV, Kusui T, Pradhan TK, et al. (1995). „Expression and characterization of cloned human bombesin receptors.”. Mol. Pharmacol. 47 (1): 10–20. PMID 7838118. 
  • Giladi E, Nagalla SR, Spindel ER (1993). „Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides.”. J. Mol. Neurosci. 4 (1): 41–54. DOI:10.1007/BF02736689. PMID 8391296. 
  • Maslen GL, Boyd Y (1993). „Comparative mapping of the Grpr locus on the X chromosomes of man and mouse.”. Genomics 17 (1): 106–9. DOI:10.1006/geno.1993.1290. PMID 8406441. 
  • Ishikawa-Brush Y, Powell JF, Bolton P, et al. (1997). „Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene.”. Hum. Mol. Genet. 6 (8): 1241–50. DOI:10.1093/hmg/6.8.1241. PMID 9259269. 
  • Heidary G, Hampton LL, Schanen NC, et al. (1998). „Exclusion of the gastrin-releasing peptide receptor (GRPR) locus as a candidate gene for Rett syndrome.”. Am. J. Med. Genet. 78 (2): 173–5. DOI:10.1002/(SICI)1096-8628(19980630)78:2<173::AID-AJMG15>3.0.CO;2-K. PMID 9674911. 
  • Shriver SP, Bourdeau HA, Gubish CT, et al. (2000). „Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer.”. J. Natl. Cancer Inst. 92 (1): 24–33. DOI:10.1093/jnci/92.1.24. PMID 10620630. 
  • Xiao D, Wang J, Hampton LL, Weber HC (2001). „The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter.”. Gene 264 (1): 95–103. DOI:10.1016/S0378-1119(00)00596-5. PMID 11245983. 
  • Carroll RE, Matkowskyj K, Saunthararajah Y, et al. (2002). „Contribution of gastrin-releasing peptide and its receptor to villus development in the murine and human gastrointestinal tract.”. Mech. Dev. 113 (2): 121–30. DOI:10.1016/S0925-4773(02)00032-1. PMID 11960700. 
  • Qu X, Xiao D, Weber HC (2002). „Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells.”. FEBS Lett. 527 (1-3): 109–13. DOI:10.1016/S0014-5793(02)03177-0. PMID 12220644. 
  • Xiao D, Qu X, Weber HC (2003). „GRP receptor-mediated immediate early gene expression and transcription factor Elk-1 activation in prostate cancer cells.”. Regul. Pept. 109 (1-3): 141–8. DOI:10.1016/S0167-0115(02)00197-0. PMID 12409226. 
  • Uchida K, Kojima A, Morokawa N, et al. (2003). „Expression of progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA transcripts in tumor cells of patients with small cell lung cancer.”. J. Cancer Res. Clin. Oncol. 128 (12): 633–40. DOI:10.1007/s00432-002-0392-8. PMID 12474049. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Shumyatsky GP, Tsvetkov E, Malleret G, et al. (2003). „Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear.”. Cell 111 (6): 905–18. DOI:10.1016/S0092-8674(02)01116-9. PMID 12526815. 
  • Glover SC, Tretiakova MS, Carroll RE, Benya RV (2003). „Increased frequency of gastrin-releasing peptide receptor gene mutations during colon-adenocarcinoma progression.”. Mol. Carcinog. 37 (1): 5–15. DOI:10.1002/mc.10117. PMID 12720295. 
  • Waters CM, MacKinnon AC, Cummings J, et al. (2003). „Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8-substance P (6-11)-induced growth inhibition.”]. Br. J. Cancer 88 (11): 1808–16. DOI:10.1038/sj.bjc.6600957. PMC 2377129. PMID 12771999. 
  • Scott N, Millward E, Cartwright EJ, et al. (2004). „Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours.”. J. Clin. Pathol. 57 (2): 189–92. DOI:10.1136/jcp.2003.10660. PMC 1770197. PMID 14747448. 
  • Chen PW, Kroog GS (2005). „Alterations in receptor expression or agonist concentration change the pathways gastrin-releasing peptide receptor uses to regulate extracellular signal-regulated kinase.”. Mol. Pharmacol. 66 (6): 1625–34. DOI:10.1124/mol.104.001206. PMID 15361544. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 

Spoljašnje veze

  • „Bombesin Receptors: BB2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
  • IUPHAR GPCR baza podataka - BB2 receptor Arhivirano 2016-03-03 na Wayback Machine-u
  • MeSH Receptors,+Bombesin
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)