POLD3

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Polimeraza (DNK vođena), delta 3, pomoćna jedinica

Prikaz POLD3 baziran na PDB 1U76
Dostupne strukture
1U76, 3E0J
Identifikatori
SimboliPOLD3; P66; P68
Vanjski IDOMIM: 611415 MGI: 1915217 HomoloGene: 38202 GeneCards: POLD3 Gene
Ontologija gena
Molekulska funkcija • Aktivnost DNK vođene DNK polimeraze
• proteinsko vezivanje
Ćelijska komponenta • nukleus
• nukleoplazma
• nukleolus
• mitohondrion
Biološki proces • S faza mitotičkog ćelijskog ciklusa
• mitotički ćelijski ciklus
• telomerno održavanje rekombinacijom
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez1071467967
EnsemblENSG00000077514ENSMUSG00000030726
UniProtQ15054Q9EQ28
Ref. Sekv. (iRNK)NM_006591NM_133692
Ref. Sekv. (protein)NP_006582NP_598453
Lokacija (UCSC)Chr 11:
74.2 - 74.38 Mb		Chr 7:
100.08 - 100.12 Mb
PubMed pretraga[1][2]

Delta podjedinica 3 DNK polimeraze je enzim koji je kod ljudi kodiran POLD3 genom.[1][2] Ona je komponenta kompleksa DNK polimeraze delta.

Interakcije

POLD3 formira interakcije sa PCNA.[3][4]

Reference

  1. ↑ Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999). „Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts”. Nucleic Acids Res 27 (10): 2108–14. DOI:10.1093/nar/27.10.2108. PMC 148430. PMID 10219083. 
  2. ↑ „Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit”. 
  3. ↑ Ducoux, M; Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (Dec 2001). „Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta”. J. Biol. Chem. (United States) 276 (52): 49258–66. DOI:10.1074/jbc.M106990200. ISSN 0021-9258. PMID 11595739. 
  4. ↑ Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct 2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. (United States) 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. ISSN 0021-9258. PMID 12171929. 

Literatura

  • Nomura N, Miyajima N, Sazuka T i dr.. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1”. DNA Res. 1 (1): 27–35. DOI:10.1093/dnares/1.1.27. PMID 7584026. 
  • Nomura N, Miyajima N, Sazuka T i dr.. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)”. DNA Res. 1 (1): 47–56. DOI:10.1093/dnares/1.1.47. PMID 7584028. 
  • Zeng XR, Jiang Y, Zhang SJ i dr.. (1994). „DNA polymerase delta is involved in the cellular response to UV damage in human cells”. J. Biol. Chem. 269 (19): 13748–51. PMID 7910606. 
  • Longley MJ, Pierce AJ, Modrich P (1997). „DNA polymerase delta is required for human mismatch repair in vitro”. J. Biol. Chem. 272 (16): 10917–21. DOI:10.1074/jbc.272.16.10917. PMID 9099749. 
  • Mo J, Liu L, Leon A i dr.. (2000). „Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA”. Biochemistry 39 (24): 7245–54. DOI:10.1021/bi0000871. PMID 10852724. 
  • Ducoux M, Urbach S, Baldacci G i dr.. (2002). „Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta”. J. Biol. Chem. 276 (52): 49258–66. DOI:10.1074/jbc.M106990200. PMID 11595739. 
  • Ohta S, Shiomi Y, Sugimoto K i dr.. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. PMID 12171929. 
  • Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Pohler JR, Otterlei M, Warbrick E (2006). „An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit”. BMC Mol. Biol. 6: 17. DOI:10.1186/1471-2199-6-17. PMC 1187890. PMID 16000169. 
  • Takemura M, Yoshida S, Akiyama T i dr.. (2006). „Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase”. Biochim. Biophys. Acta 1764 (9): 1447–53. DOI:10.1016/j.bbapap.2006.06.015. PMID 16935576. 
  • Olsen JV, Blagoev B, Gnad F i dr.. (2006). „Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell 127 (3): 635–48. DOI:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Masuda Y, Suzuki M, Piao J i dr.. (2007). „Dynamics of human replication factors in the elongation phase of DNA replication”. Nucleic Acids Res. 35 (20): 6904–16. DOI:10.1093/nar/gkm822. PMC 2175312. PMID 17932049. 


  • p
  • r
  • u
Separacija
i inicijacija
Prokariotska
(inicijacija)
Eukariotska
(priprema u
G1 fazi)
Oba
Replikacija
Prokariotska
(elongacija)
Eukariotska
(sinteza u
S fazi)
Oba
Kretanje: Procesivnost • DNK ligaza
Terminacija
B bsyn: dnk (repl, cycl, reco, repr) • tscr (fact, tcrg, nucl, rnat, rept, ptts) • tltn (risu, pttl, nexn) • dnab, rnab/runp • stru (domn, 1°, 2°, 3°, 4°)