SSBP1

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Protein 1 vezivanja jednolančane DNK, mitohondrijski

PDB prikaz baziran na 1s3o.
Dostupne strukture
1S3O, 2DUD, 3ULL
Identifikatori
SimboliSSBP1; Mt-SSB; SOSS-B1; SSBP; mtSSB
Vanjski IDOMIM: 600439 MGI: 1920040 HomoloGene: 74462 GeneCards: SSBP1 Gene
Ontologija gena
Molekulska funkcija hromatinsko vezivanje
Protein vezivanja jednolančane DNK
proteinsko vezivanje
Ćelijska komponenta mitohondrija
mitohondrijski nukleoid
Biološki proces DNK replikacija
pozitivna regulacija helikazne aktivnosti
mitohondrijska morfogeneza
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez6742381760
EnsemblENSG00000106028ENSMUSG00000029911
UniProtQ04837Q9CYR0
Ref. Sekv. (iRNK)NM_001256510NM_028358
Ref. Sekv. (protein)NP_001243439NP_082634
Lokacija (UCSC)Chr 7:
141.44 - 141.49 Mb
Chr 6:
40.47 - 40.48 Mb
PubMed pretraga[1][2]

Protein 1 vezivanja jednolančane DNK, mitohondrijski je protein koji je kod ljudi kodiran SSBP1 genom.[1][2]

Reference

  1. Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S, Zuffardi O, Zeviani M (Jul 1995). „Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis”. Genomics 25 (2): 559–564. DOI:10.1016/0888-7543(95)80058-T. PMID 7789991. 
  2. „Entrez Gene: SSBP1 single-stranded DNA binding protein 1”. 

Literatura

  • Tiranti V, Rocchi M, DiDonato S, Zeviani M (1993). „Cloning of human and rat cDNAs encoding the mitochondrial single-stranded DNA-binding protein (SSB)”. Gene 126 (2): 219–225. DOI:10.1016/0378-1119(93)90370-I. PMID 8482537. 
  • Yang C, Curth U, Urbanke C, Kang C (1997). „Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution”. Nat. Struct. Biol. 4 (2): 153–157. DOI:10.1038/nsb0297-153. PMID 9033597. 
  • Schultz RA, Swoap SJ, McDaniel LD i dr.. (1998). „Differential expression of mitochondrial DNA replication factors in mammalian tissues”. J. Biol. Chem. 273 (6): 3447–3451. DOI:10.1074/jbc.273.6.3447. PMID 9452467. 
  • Spelbrink JN, Toivonen JM, Hakkaart GA i dr.. (2000). „In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells”. J. Biol. Chem. 275 (32): 24818–24828. DOI:10.1074/jbc.M000559200. PMID 10827171. 
  • Müller-Höcker J, Schäfer S, Li K (2002). „Immunocytochemical localization of mitochondrial single-stranded DNA-binding protein in mitochondria-rich cells of normal and neoplastic human tissue”. Appl. Immunohistochem. Mol. Morphol. 9 (3): 276–280. DOI:10.1097/00022744-200109000-00013. PMID 11556757. 
  • Takamatsu C, Umeda S, Ohsato T i dr.. (2002). „Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein”. EMBO Rep. 3 (5): 451–456. DOI:10.1093/embo-reports/kvf099. PMC 1084112. PMID 11964388. 
  • Chen L, Segal D, Hukriede NA i dr.. (2002). „Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development”. Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14320–14325. DOI:10.1073/pnas.212532399. PMC 137882. PMID 12381786. 
  • Diez-Tascón C, Dodds KG, Crawford AM (2003). „Linkage mapping of the ovine single-stranded DNA-binding protein 1 (SSBP1) using microsatellite marker OARCDT7”. Anim. Genet. 33 (6): 468–468. DOI:10.1046/j.1365-2052.2002.00938_1.x. PMID 12464025. 
  • Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Bayarsaihan D (2003). „SSDP1 gene encodes a protein with a conserved N-terminal FORWARD domain”. Biochim. Biophys. Acta 1599 (1–2): 152–5. DOI:10.1016/s1570-9639(02)00376-x. PMID 12479417. 
  • Scherer SW, Cheung J, MacDonald JR i dr.. (2003). „Human chromosome 7: DNA sequence and biology”. Science 300 (5620): 767–772. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205. 
  • Hillier LW, Fulton RS, Fulton LA i dr.. (2003). „The DNA sequence of human chromosome 7”. Nature 424 (6945): 157–164. DOI:10.1038/nature01782. PMID 12853948. 
  • Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–2127. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Pocernich CB, Poon HF, Boyd-Kimball D i dr.. (2005). „Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat”. Brain Res. Mol. Brain Res. 133 (2): 299–306. DOI:10.1016/j.molbrainres.2004.10.024. PMID 15710247. 
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PDB Galerija
1s3o: Ljudki mitohondrijski protein vezivanja jednolančane DNK (hmSSB)
1s3o: Ljudki mitohondrijski protein vezivanja jednolančane DNK (hmSSB)  
2dud: Kristalna struktura ljudskog mitohondrijskog proteina vezivanja jednolančane DNK (hmtSSB)
2dud: Kristalna struktura ljudskog mitohondrijskog proteina vezivanja jednolančane DNK (hmtSSB)  
3ull: Ljudki mitohondrijski protein vezivanja jednolančane DNK
3ull: Ljudki mitohondrijski protein vezivanja jednolančane DNK  
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Separacija
i inicijacija
Prokariotska
(inicijacija)
Eukariotska
(priprema u
G1 fazi)
Oba
Replikacija
Prokariotska
(elongacija)
Eukariotska
(sinteza u
S fazi)
Oba
Kretanje: Procesivnost  DNK ligaza
Terminacija
B bsyn: dnk (repl, cycl, reco, repr)  tscr (fact, tcrg, nucl, rnat, rept, ptts)  tltn (risu, pttl, nexn)  dnab, rnab/runp  stru (domn, 1°, 2°, 3°, 4°)