KIF3C

Protein-coding gene in the species Homo sapiens
KIF3C
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3B6V

Identifiers
AliasesKIF3C, kinesin family member 3C
External IDsOMIM: 602845; MGI: 107979; HomoloGene: 55640; GeneCards: KIF3C; OMA:KIF3C - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for KIF3C
Genomic location for KIF3C
Band2p23.3Start25,926,598 bp[1]
End25,982,749 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for KIF3C
Genomic location for KIF3C
Band12 A1.1|12 1.77 cMStart3,415,132 bp[2]
End3,456,494 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • Brodmann area 46

  • pons

  • prefrontal cortex

  • orbitofrontal cortex

  • frontal pole

  • right frontal lobe

  • superior frontal gyrus

  • dorsolateral prefrontal cortex

  • postcentral gyrus
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • medial dorsal nucleus

  • superior frontal gyrus

  • dorsal tegmental nucleus

  • ventral tegmental area

  • medial geniculate nucleus

  • lateral geniculate nucleus

  • medial vestibular nucleus

  • pontine nuclei

  • cerebellar cortex
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • microtubule binding
  • microtubule motor activity
  • nucleotide binding
  • ATPase activity
  • cytoskeletal motor activity
  • ATP binding
Cellular component
  • cytoplasm
  • cytosol
  • ciliary tip
  • microtubule
  • cytoskeleton
  • kinesin complex
  • cilium
Biological process
  • microtubule-based movement
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • organelle transport along microtubule
  • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
  • intraciliary transport involved in cilium assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3797

16570

Ensembl

ENSG00000084731

ENSMUSG00000020668

UniProt

O14782

O35066

RefSeq (mRNA)

NM_002254

NM_008445

RefSeq (protein)

NP_002245

NP_032471

Location (UCSC)Chr 2: 25.93 – 25.98 MbChr 12: 3.42 – 3.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin-like protein KIF3C is a protein that in humans is encoded by the KIF3C gene.[5][6] It is part of the kinesin family of motor proteins.


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000084731 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020668 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sardella M, Navone F, Rocchi M, Rubartelli A, Viggiano L, Vignali G, Consalez GG, Sitia R, Cabibbo A (Apr 1998). "KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23". Genomics. 47 (3): 405–8. doi:10.1006/geno.1997.5123. PMID 9480755.
  6. ^ "Entrez Gene: KIF3C kinesin family member 3C".

Further reading

  • Davidovic L, Jaglin XH, Lepagnol-Bestel AM, et al. (2008). "The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules". Hum. Mol. Genet. 16 (24): 3047–58. doi:10.1093/hmg/ddm263. PMID 17881655.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Elenich LA, Nandi D, Kent AE, et al. (1999). "The complete primary structure of mouse 20S proteasomes". Immunogenetics. 49 (10): 835–42. doi:10.1007/s002510050562. PMID 10436176. S2CID 20977116.
  • Muresan V, Abramson T, Lyass A, et al. (1998). "KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles". Mol. Biol. Cell. 9 (3): 637–52. doi:10.1091/mbc.9.3.637. PMC 25292. PMID 9487132.
  • Yang Z, Goldstein LS (1998). "Characterization of the KIF3C neural kinesin-like motor from mouse". Mol. Biol. Cell. 9 (2): 249–61. doi:10.1091/mbc.9.2.249. PMC 25248. PMID 9450952.
  • Telford EA, Wightman P, Leek J, et al. (1998). "cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C". Biochem. Biophys. Res. Commun. 242 (2): 407–12. doi:10.1006/bbrc.1997.7977. PMID 9446808.

External links

  • Overview of all the structural information available in the PDB for UniProt: O14782 (Human Kinesin-like protein KIF3C) at the PDBe-KB.


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Human
Microfilaments
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filaments
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See also: cytoskeletal defects