MYH7B

Protein-coding gene in the species Homo sapiens
MYH7B
Identifiers
AliasesMYH7B, MHC14, MYH14, myosin, heavy chain 7B, cardiac muscle, beta, myosin heavy chain 7B
External IDsOMIM: 609928; MGI: 3710243; HomoloGene: 66117; GeneCards: MYH7B; OMA:MYH7B - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for MYH7B
Genomic location for MYH7B
Band20q11.22Start34,955,810 bp[1]
End35,002,437 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for MYH7B
Genomic location for MYH7B
Band2|2 H1Start155,453,132 bp[2]
End155,476,227 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • muscle of thigh

  • left ventricle

  • right auricle

  • Skeletal muscle tissue of rectus abdominis

  • body of tongue

  • biceps brachii

  • Skeletal muscle tissue of biceps brachii

  • lateral nuclear group of thalamus

  • sperm
Top expressed in
  • vascular smooth muscle

  • lens

  • neural layer of retina

  • left ventricle

  • soleus muscle

  • vasculature of trunk

  • superior frontal gyrus

  • cerebellar cortex

  • myocardium of atrium

  • primary visual cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • actin binding
  • cytoskeletal motor activity
  • protein binding
  • ATP binding
  • actin filament binding
  • microtubule motor activity
  • microtubule binding
Cellular component
  • myosin filament
  • membrane
  • myosin complex
  • cardiac myofibril
Biological process
  • microtubule-based movement
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57644

668940

Ensembl

ENSG00000078814

ENSMUSG00000074652

UniProt

Q5JW45

A2AQP0

RefSeq (mRNA)

NM_020884
NM_033424

NM_001085378

RefSeq (protein)

NP_065935

NP_001078847

Location (UCSC)Chr 20: 34.96 – 35 MbChr 2: 155.45 – 155.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin-7B also known as myosin, heavy chain 7B is a protein that in humans is encoded by the MYH7B gene.[5][6]

Function

MYH7B is a slow-twitch myosin.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000078814 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074652 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  6. ^ a b Desjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH (April 2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 (4): 375–93. doi:10.1093/oxfordjournals.molbev.a004093. PMID 11919279.

Further reading

  • Rossi AC, Mammucari C, Argentini C, et al. (2010). "Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles". J. Physiol. 588 (Pt 2): 353–64. doi:10.1113/jphysiol.2009.181008. PMC 2821527. PMID 19948655.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • McGuigan K, Phillips PC, Postlethwait JH (2004). "Evolution of sarcomeric myosin heavy chain genes: evidence from fish". Mol. Biol. Evol. 21 (6): 1042–56. doi:10.1093/molbev/msh103. PMID 15014174.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hu Z, Liang J, Wang Z, et al. (2009). "Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women". Hum. Mutat. 30 (1): 79–84. doi:10.1002/humu.20837. PMID 18634034. S2CID 41225773.
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects


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