CD1A

Mammalian protein found in Homo sapiens

CD1A

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
1ONQ, 1XZ0, 4X6C, 4X6D, 4X6E, 4X6F

Identifiers

Aliases

CD1A, CD1, FCB6, HTA1, R4, T6, CD1a molecule

External IDs

OMIM: 188370 HomoloGene: 113556 GeneCards: CD1A

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q23.1	Start	158,254,424 bp^[1]
Band	1q23.1	End	158,258,269 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

thymus

gums

skin of abdomen

monocyte

vulva

oral cavity

cervix epithelium

lymph node

appendix

gallbladder

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	beta-2-microglobulin binding endogenous lipid antigen binding protein binding exogenous lipid antigen binding lipopeptide binding
Cellular component	integral component of membrane membrane raft endosome integral component of plasma membrane endosome membrane membrane plasma membrane cell surface extracellular space external side of plasma membrane
Biological process	antigen processing and presentation, exogenous lipid antigen via MHC class Ib adaptive immune response immune system process immune response regulation of immune response positive regulation of T cell mediated cytotoxicity antigen processing and presentation, endogenous lipid antigen via MHC class Ib
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


909


n/a

Ensembl


ENSG00000158477


n/a

UniProt


P06126


n/a

RefSeq (mRNA)


NM_001763 NM_001320652


n/a

RefSeq (protein)


NP_001307581 NP_001754


n/a

Location (UCSC)

Chr 1: 158.25 – 158.26 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

CD1a (Cluster of Differentiation 1a) is a human protein encoded by the CD1A gene.^[3]

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytotic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.^[3] Transcript levels of the CD1A gene are upregulated in the lung parenchyma of smokers.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158477 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CD1A CD1a molecule".
^ Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F (September 2019). "Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients". Scientific Reports. 9 (1): 13039. Bibcode:2019NatSR...913039P. doi:10.1038/s41598-019-49648-2. PMC 6736939. PMID 31506599.

External links

Human CD1A genome location and CD1A gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P06126 (Human T-cell surface glycoprotein CD1a) at the PDBe-KB.

Melián A, Beckman EM, Porcelli SA, Brenner MB (1996). "Antigen presentation by CD1 and MHC-encoded class I-like molecules". Curr. Opin. Immunol. 8 (1): 82–8. doi:10.1016/S0952-7915(96)80109-9. PMID 8729450.
Park SH, Bendelac A (2000). "CD1-restricted T-cell responses and microbial infection". Nature. 406 (6797): 788–92. Bibcode:2000Natur.406..788P. doi:10.1038/35021233. PMID 10963609. S2CID 4373172.
Brigl M, Brenner MB (2004). "CD1: antigen presentation and T cell function". Annu. Rev. Immunol. 22 (1): 817–90. doi:10.1146/annurev.immunol.22.012703.104608. PMID 15032598.
Coventry B, Heinzel S (2004). "CD1a in human cancers: a new role for an old molecule". Trends Immunol. 25 (5): 242–8. doi:10.1016/j.it.2004.03.002. PMID 15099564.
Moody DB, Zajonc DM, Wilson IA (2005). "Anatomy of CD1-lipid antigen complexes". Nat. Rev. Immunol. 5 (5): 387–99. doi:10.1038/nri1605. PMID 15864273. S2CID 1387491.
Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.
Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB J. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296. S2CID 3111709.
Oakey RJ, Watson ML, Seldin MF (1993). "Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA". Hum. Mol. Genet. 1 (8): 613–20. doi:10.1093/hmg/1.8.613. PMID 1301170.
Martin LH, Calabi F, Lefebvre FA, et al. (1988). "Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9189–93. doi:10.1073/pnas.84.24.9189. PMC 299718. PMID 2447586.
Moseley WS, Watson ML, Kingsmore SF, Seldin MF (1989). "CD1 defines conserved linkage group border between human chromosomes 1 and mouse chromosomes 1 and 3". Immunogenetics. 30 (5): 378–82. doi:10.1007/BF02425278. PMID 2478463. S2CID 9361881.
Yu CY, Milstein C (1990). "A physical map linking the five CD1 human thymocyte differentiation antigen genes". EMBO J. 8 (12): 3727–32. doi:10.1002/j.1460-2075.1989.tb08548.x. PMC 402056. PMID 2583117.
Aruffo A, Seed B (1989). "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts". J. Immunol. 143 (5): 1723–30. doi:10.4049/jimmunol.143.5.1723. PMID 2701945. S2CID 23168239.
Longley J, Kraus J, Alonso M, Edelson R (1989). "Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules". J. Invest. Dermatol. 92 (4): 628–31. doi:10.1111/1523-1747.ep12712175. PMID 2784820.
Albertson DG, Fishpool R, Sherrington P, et al. (1988). "Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1". EMBO J. 7 (9): 2801–5. doi:10.1002/j.1460-2075.1988.tb03135.x. PMC 457071. PMID 3053166.
Calabi F, Milstein C (1986). "A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6". Nature. 323 (6088): 540–3. Bibcode:1986Natur.323..540C. doi:10.1038/323540a0. PMID 3093894. S2CID 4274219.
Martin LH, Calabi F, Milstein C (1987). "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154–8. doi:10.1073/pnas.83.23.9154. PMC 387093. PMID 3097645.
Woolfson A, Milstein C (1994). "Alternative splicing generates secretory isoforms of human CD1". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6683–7. Bibcode:1994PNAS...91.6683W. doi:10.1073/pnas.91.14.6683. PMC 44267. PMID 7517559.
Han M, Hannick LI, DiBrino M, Robinson MA (2000). "Polymorphism of human CD1 genes". Tissue Antigens. 54 (2): 122–7. doi:10.1034/j.1399-0039.1999.540202.x. PMID 10488738.
Sugita M, Grant EP, van Donselaar E, et al. (2000). "Separate pathways for antigen presentation by CD1 molecules". Immunity. 11 (6): 743–52. doi:10.1016/S1074-7613(00)80148-X. PMID 10626896.

PDB gallery

1onq: Crystal Structure of CD1a in Complex with a Sulfatide
1xz0: Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350