CD300A

Human gene
CD300A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2Q87

Identifiers
AliasesCD300A, CLM-8, CMRF-35-H9, CMRF-35H, CMRF35-H, CMRF35-H9, CMRF35H, CMRF35H9, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60, CD300a molecule
External IDsOMIM: 606790; MGI: 2443411; HomoloGene: 48514; GeneCards: CD300A; OMA:CD300A - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CD300A
Genomic location for CD300A
Band17q25.1Start74,466,399 bp[1]
End74,484,794 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • blood

  • monocyte

  • spleen

  • bone marrow

  • bone marrow cells

  • amniotic fluid

  • appendix

  • periodontal fiber

  • lymph node
    n/a
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • signaling receptor activity
  • phosphatidylethanolamine binding
  • phosphatidylserine binding
  • protein binding
Cellular component
  • integral component of membrane
  • extracellular exosome
  • membrane
  • plasma membrane
  • tertiary granule membrane
  • ficolin-1-rich granule membrane
Biological process
  • regulation of T cell receptor signaling pathway
  • immune system process
  • negative regulation of eosinophil migration
  • positive regulation of phosphoprotein phosphatase activity
  • negative regulation of neutrophil activation
  • negative regulation of eosinophil activation
  • regulation of immune response
  • negative regulation of fibroblast proliferation
  • negative regulation of MAP kinase activity
  • negative regulation of mast cell degranulation
  • negative regulation of mast cell activation involved in immune response
  • cell adhesion
  • negative regulation of NK T cell activation
  • negative regulation of B cell receptor signaling pathway
  • negative regulation of activation of Janus kinase activity
  • negative regulation of phagocytosis, engulfment
  • negative regulation of B cell proliferation
  • signal transduction
  • negative regulation of MyD88-dependent toll-like receptor signaling pathway
  • neutrophil degranulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11314

217303

Ensembl

ENSG00000167851

n/a

UniProt

Q9UGN4

Q6SJQ0

RefSeq (mRNA)

NM_001256841
NM_007261
NM_001330456
NM_001330457

NM_170758
NM_001347654
NM_001359812

RefSeq (protein)

NP_001243770
NP_001317385
NP_001317386
NP_009192

NP_001334583
NP_739564
NP_001346741

Location (UCSC)Chr 17: 74.47 – 74.48 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

CD300A (Cluster of Differentiation 300A) is a human gene.[4]

The CMRF35 antigen (CMRF35A; MIM 606786), which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes. CMRF35H is recognized by the same antibody and is distinct from CMRF35 (Green et al., 1998).[supplied by OMIM][4]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167851 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b "Entrez Gene: CD300A CD300a molecule".

Further reading

  • Clark GJ, Fitzpatrick S, Kuo B, et al. (2003). "CMRF-35A, CMRF-35H: potential new CD". J. Biol. Regul. Homeost. Agents. 16 (3): 233–5. PMID 12456026.
  • Alvarez Y, Tang X, Coligan JE, Borrego F (2007). "The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling". Mol. Immunol. 45 (1): 253–8. doi:10.1016/j.molimm.2007.05.006. PMC 2000843. PMID 17588661.
  • Bachelet I, Munitz A, Moretta A, et al. (2006). "The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells". J. Immunol. 175 (12): 7989–95. doi:10.4049/jimmunol.175.12.7989. PMID 16339535.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark GJ, Green BJ, Hart DN (2000). "The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17". Tissue Antigens. 55 (2): 101–9. doi:10.1034/j.1399-0039.2000.550201.x. PMID 10746781.
  • Cantoni C, Bottino C, Augugliaro R, et al. (1999). "Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells". Eur. J. Immunol. 29 (10): 3148–59. doi:10.1002/(SICI)1521-4141(199910)29:10<3148::AID-IMMU3148>3.0.CO;2-L. PMID 10540326. S2CID 8828216.
  • Green BJ, Clark GJ, Hart DN (1998). "The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor". Int. Immunol. 10 (7): 891–9. doi:10.1093/intimm/10.7.891. PMID 9701027.
  • Jackson DG, Hart DN, Starling G, Bell JI (1992). "Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor". Eur. J. Immunol. 22 (5): 1157–63. doi:10.1002/eji.1830220508. PMID 1349532. S2CID 23437463.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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