SIRPB1

Protein-coding gene in the species Homo sapiens
SIRPB1
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2D9C, 2JJU,%%s2JJV

Identifiers
AliasesSIRPB1, CD172b, SIRP-BETA-1, signal regulatory protein beta 1
External IDsOMIM: 603889; MGI: 3779828; HomoloGene: 82993; GeneCards: SIRPB1; OMA:SIRPB1 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SIRPB1
Genomic location for SIRPB1
Band20p13Start1,561,385 bp[1]
End1,620,061 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for SIRPB1
Genomic location for SIRPB1
Band3 A1|3Start15,560,811 bp[2]
End15,640,125 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • blood

  • right lung

  • spleen

  • bone marrow

  • bone marrow cells

  • appendix

  • gallbladder

  • lymph node

  • upper lobe of left lung
Top expressed in
  • spermatid

  • secondary oocyte

  • bone marrow

  • spleen

  • lung

  • jejunum

  • liver

  • uterus

  • spermatocyte

  • ovary
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • integral component of plasma membrane
  • membrane
  • secretory granule membrane
  • cell surface
Biological process
  • cell surface receptor signaling pathway
  • innate immune response
  • signal transduction
  • neutrophil degranulation
  • positive regulation of cell-cell adhesion
  • positive regulation of phagocytosis
  • positive regulation of T cell activation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10326

668101

Ensembl

ENSG00000101307

ENSMUSG00000095028

UniProt

O00241
Q5TFQ8

n/a

RefSeq (mRNA)

NM_001083910
NM_001135844
NM_006065
NM_001329157
NM_001330639

NM_001173460

RefSeq (protein)
NP_001077379
NP_001129316
NP_001316086
NP_001317568
NP_006056

NP_001129316.1

n/a

Location (UCSC)Chr 20: 1.56 – 1.62 MbChr 3: 15.56 – 15.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.[5][6][7] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.[7]

Interactions

SIRPB1 has been shown to interact with TYROBP.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101307 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000095028 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J, Ullrich A (April 1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181–6. Bibcode:1997Natur.386..181K. doi:10.1038/386181a0. PMID 9062191. S2CID 4259314.
  6. ^ van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (December 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511. S2CID 41479985.
  7. ^ a b "Entrez Gene: SIRPB1 signal-regulatory protein beta 1".
  8. ^ Dietrich J, Cella M, Seiffert M, Bühring H J, Colonna M (January 2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. 164 (1). UNITED STATES: 9–12. doi:10.4049/jimmunol.164.1.9. ISSN 0022-1767. PMID 10604985.
  9. ^ Tomasello E, Cant C, Bühring H J, Vély F, André P, Seiffert M, Ullrich A, Vivier E (August 2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. 30 (8). GERMANY: 2147–56. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. ISSN 0014-2980. PMID 10940905. S2CID 84258013.

Further reading

  • Dietrich J, Cella M, Seiffert M, et al. (2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. 164 (1): 9–12. doi:10.4049/jimmunol.164.1.9. PMID 10604985.
  • Tomasello E, Cant C, Bühring HJ, et al. (2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. 30 (8): 2147–56. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. PMID 10940905. S2CID 84258013.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Cannon JP, Haire RN, Litman GW (2002). "Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate". Nat. Immunol. 3 (12): 1200–7. doi:10.1038/ni849. PMID 12415263. S2CID 19367972.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Liu Y, Soto I, Tong Q, et al. (2006). "SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration". J. Biol. Chem. 280 (43): 36132–40. doi:10.1074/jbc.M506419200. PMID 16081415.
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
  • Laplana M, Royo JL, Aluja A, López R, Heine-Sunyer H, Fibla J (September 2014). "SIRPB1 copy-number polymorphism as candidate quantitative trait locus for impulsive-disinhibited personality". Genes, Brain and Behavior. 13 (7): 653–62. doi:10.1111/gbb.12154. hdl:10486/667487. PMID 25039969.

External links

  • v
  • t
  • e
  • 2d9c: Solution structure of the first ig-like domain of signal-regulatory protein beta-1 (SIRP-beta-1)
    2d9c: Solution structure of the first ig-like domain of signal-regulatory protein beta-1 (SIRP-beta-1)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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