CLEC4M

Protein-coding gene in the species Homo sapiens
CLEC4M
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1K9J, 1SL6, 1XAR, 1XPH, 3JQH

Identifiers
AliasesCLEC4M, CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M
External IDsOMIM: 605872; MGI: 2157942; HomoloGene: 129771; GeneCards: CLEC4M; OMA:CLEC4M - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CLEC4M
Genomic location for CLEC4M
Band19p13.2Start7,763,210 bp[1]
End7,769,605 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for CLEC4M
Genomic location for CLEC4M
Band8|8 A1.1Start3,793,397 bp[2]
End3,798,984 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • germinal epithelium

  • lymph node

  • pancreatic ductal cell

  • right lung

  • testicle

  • placenta

  • left ovary

  • right adrenal gland

  • left adrenal cortex
Top expressed in
  • granulocyte

  • lip

  • skin of abdomen

  • right kidney

  • muscle of thigh

  • spleen

  • right lung lobe

  • white adipose tissue

  • carotid body

  • skin of external ear
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • peptide antigen binding
  • virus receptor activity
  • metal ion binding
  • calcium-dependent protein binding
  • mannose binding
  • virion binding
  • ICAM-3 receptor activity
  • carbohydrate binding
  • signaling receptor activity
  • protein binding
Cellular component
  • cytoplasm
  • integral component of membrane
  • membrane
  • plasma membrane
  • integral component of plasma membrane
  • extracellular region
  • host cell
Biological process
  • leukocyte cell-cell adhesion
  • cell-cell recognition
  • intracellular transport of virus
  • intracellular signal transduction
  • antigen processing and presentation
  • endocytosis
  • adaptive immune response
  • immune system process
  • viral genome replication
  • peptide antigen transport
  • modulation by virus of host process
  • innate immune response
  • viral process
  • virion attachment to host cell
  • viral entry into host cell
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10332

170786

Ensembl

ENSG00000104938

ENSMUSG00000031494

UniProt

Q9H2X3

Q91ZX1

RefSeq (mRNA)
NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908

NM_001144909
NM_001144910
NM_001144911
NM_014257
NM_214675
NM_214676

NM_133238

RefSeq (protein)
NP_001138376
NP_001138377
NP_001138378
NP_001138379
NP_001138380

NP_001138381
NP_001138382
NP_001138383
NP_055072

NP_573501

Location (UCSC)Chr 19: 7.76 – 7.77 MbChr 8: 3.79 – 3.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene.[5] CLEC4M has also been designated as CD299 (cluster of differentiation 299).

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104938 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031494 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (Apr 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.
  6. ^ "Entrez Gene: CLEC4M C-type lectin domain family 4, member M".

Further reading

  • Baribaud F, Doms RW, Pöhlmann S (2006). "The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?". Expert Opin. Ther. Targets. 6 (4): 423–31. doi:10.1517/14728222.6.4.423. PMID 12223058. S2CID 21541850.
  • Becker Y (2004). "HIV-1 gp120 binding to dendritic cell receptors mobilize the virus to the lymph nodes, but the induced IL-4 synthesis by FcepsilonRI+ hematopoietic cells damages the adaptive immunity--a review, hypothesis, and implications". Virus Genes. 29 (1): 147–65. doi:10.1023/B:VIRU.0000032797.43537.d3. PMID 15215692. S2CID 5666009.
  • Lalor PF, Lai WK, Curbishley SM, et al. (2006). "Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo". World J. Gastroenterol. 12 (34): 5429–39. doi:10.3748/wjg.v12.i34.5429. PMC 4088223. PMID 17006978.
  • Curtis BM, Scharnowske S, Watson AJ (1992). "Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8356–60. Bibcode:1992PNAS...89.8356C. doi:10.1073/pnas.89.17.8356. PMC 49917. PMID 1518869.
  • Gattegno L, Ramdani A, Jouault T, et al. (1992). "Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1)". AIDS Res. Hum. Retroviruses. 8 (1): 27–37. doi:10.1089/aid.1992.8.27. PMID 1736938.
  • Soilleux EJ, Barten R, Trowsdale J (2000). "DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13". J. Immunol. 165 (6): 2937–42. doi:10.4049/jimmunol.165.6.2937. PMID 10975799.
  • Pöhlmann S, Soilleux EJ, Baribaud F, et al. (2001). "DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2670–5. Bibcode:2001PNAS...98.2670P. doi:10.1073/pnas.051631398. PMC 30196. PMID 11226297.
  • Bashirova AA, Geijtenbeek TB, van Duijnhoven GC, et al. (2001). "A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection". J. Exp. Med. 193 (6): 671–8. doi:10.1084/jem.193.6.671. PMC 2193415. PMID 11257134.
  • Mummidi S, Catano G, Lam L, et al. (2001). "Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts". J. Biol. Chem. 276 (35): 33196–212. doi:10.1074/jbc.M009807200. PMID 11337487.
  • Mitchell DA, Fadden AJ, Drickamer K (2001). "A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands". J. Biol. Chem. 276 (31): 28939–45. doi:10.1074/jbc.M104565200. PMID 11384997.
  • Feinberg H, Mitchell DA, Drickamer K, Weis WI (2002). "Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR". Science. 294 (5549): 2163–6. doi:10.1126/science.1066371. PMID 11739956. S2CID 25046581.
  • Alvarez CP, Lasala F, Carrillo J, et al. (2002). "C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans". J. Virol. 76 (13): 6841–4. doi:10.1128/JVI.76.13.6841-6844.2002. PMC 136246. PMID 12050398.
  • Soilleux EJ, Morris LS, Rushbrook S, et al. (2002). "Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity". Hum. Pathol. 33 (6): 652–9. doi:10.1053/hupa.2002.124036. PMID 12152166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lin G, Simmons G, Pöhlmann S, et al. (2003). "Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR". J. Virol. 77 (2): 1337–46. doi:10.1128/JVI.77.2.1337-1346.2003. PMC 140807. PMID 12502850.
  • Pöhlmann S, Zhang J, Baribaud F, et al. (2003). "Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR". J. Virol. 77 (7): 4070–80. doi:10.1128/JVI.77.7.4070-4080.2003. PMC 150620. PMID 12634366.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Engering A, van Vliet SJ, Hebeda K, et al. (2004). "Dynamic populations of dendritic cell-specific ICAM-3 grabbing nonintegrin-positive immature dendritic cells and liver/lymph node-specific ICAM-3 grabbing nonintegrin-positive endothelial cells in the outer zones of the paracortex of human lymph nodes". Am. J. Pathol. 164 (5): 1587–95. doi:10.1016/S0002-9440(10)63717-0. PMC 1615649. PMID 15111305.
  • v
  • t
  • e
  • 1k9j: Complex of DC-SIGNR and GlcNAc2Man3
    1k9j: Complex of DC-SIGNR and GlcNAc2Man3
  • 1sl6: Crystal Structure of a fragment of DC-SIGNR (containing the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.
    1sl6: Crystal Structure of a fragment of DC-SIGNR (containing the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.
  • 1xar: Crystal Structure of a fragment of DC-SIGNR (containing the carbohydrate recognition domain and two repeats of the neck).
    1xar: Crystal Structure of a fragment of DC-SIGNR (containing the carbohydrate recognition domain and two repeats of the neck).
  • 1xph: Structure of DC-SIGNR and a portion of repeat domain 8
    1xph: Structure of DC-SIGNR and a portion of repeat domain 8

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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