IGSF2

Human gene
CD101
Identifiers
AliasesCD101, EWI-101, IGSF2, V7, CD101 molecule
External IDsOMIM: 604516; MGI: 2685862; HomoloGene: 3142; GeneCards: CD101; OMA:CD101 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CD101
Genomic location for CD101
Band1p13.1Start117,001,750 bp[1]
End117,036,552 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for CD101
Genomic location for CD101
Band3|3 F2.2Start100,900,845 bp[2]
End100,936,872 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • right lung

  • bone marrow cells

  • upper lobe of left lung

  • blood

  • rectum

  • spleen

  • ganglionic eminence

  • cingulate gyrus

  • appendix
Top expressed in
  • morula

  • jejunum

  • duodenum

  • bone marrow

  • ileum

  • lung

  • colon

  • thymus

  • spleen

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Cellular component
  • plasma membrane
  • extracellular exosome
  • membrane
  • integral component of membrane
Biological process
  • cell surface receptor signaling pathway
  • positive regulation of myeloid leukocyte differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9398

630146

Ensembl

ENSG00000134256

ENSMUSG00000086564

UniProt

Q93033

A8E0Y8

RefSeq (mRNA)

NM_001256106
NM_001256109
NM_001256111
NM_004258

NM_001099332
NM_001167906

RefSeq (protein)

NP_001243035
NP_001243038
NP_001243040
NP_004249

NP_001161378

Location (UCSC)Chr 1: 117 – 117.04 MbChr 3: 100.9 – 100.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Immunoglobulin superfamily, member 2 (IGSF2) also known as CD101 (Cluster of Differentiation 101), is a human gene.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134256 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000086564 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: IGSF2 immunoglobulin superfamily, member 2".

Further reading

  • Rivas A, Ruegg CL, Zeitung J, et al. (1995). "V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies". J. Immunol. 154 (9): 4423–33. doi:10.4049/jimmunol.154.9.4423. PMID 7722299.
  • Ruegg CL, Rivas A, Madani ND, et al. (1995). "V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene". J. Immunol. 154 (9): 4434–43. doi:10.4049/jimmunol.154.9.4434. PMID 7722300. S2CID 22225700.
  • Soares LR, Rivas A, Tsavaler L, Engleman EG (1997). "Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism". J. Immunol. 159 (3): 1115–24. doi:10.4049/jimmunol.159.3.1115. PMID 9233604. S2CID 32846335.
  • Bagot M, Martinel I, Charue D, et al. (1998). "CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation". Tissue Antigens. 50 (5): 439–48. doi:10.1111/j.1399-0039.1997.tb02898.x. PMID 9389317.
  • Soares LR, Tsavaler L, Rivas A, Engleman EG (1998). "V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation". J. Immunol. 161 (1): 209–17. doi:10.4049/jimmunol.161.1.209. PMID 9647226. S2CID 24815632.
  • Bouloc A, Boulland ML, Geissmann F, et al. (2000). "CD101 expression by Langerhans cell histiocytosis cells". Histopathology. 36 (3): 229–32. doi:10.1046/j.1365-2559.2000.00827.x. PMID 10692025. S2CID 36983914.
  • Bouloc A, Bagot M, Delaire S, et al. (2001). "Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production". Eur. J. Immunol. 30 (11): 3132–9. doi:10.1002/1521-4141(200011)30:11<3132::AID-IMMU3132>3.0.CO;2-E. PMID 11093127. S2CID 45350340.
  • Stipp CS, Kolesnikova TV, Hemler ME (2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J. Biol. Chem. 276 (44): 40545–54. doi:10.1074/jbc.M107338200. PMID 11504738.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Meyer N, Petrella T, Poszepczynska-Guigne E, et al. (2005). "CD4+ CD56+ blastic tumor cells express CD101 molecules". J. Invest. Dermatol. 124 (3): 668–9. doi:10.1111/j.0022-202X.2005.23617.x. PMID 15737213.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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