CD 205

Protein-coding gene in the species Homo sapiens

LY75

Identifiers

Aliases

LY75, CD205, CLEC13B, DEC-205, GP200-MR6, LY-75, lymphocyte antigen 75

External IDs

OMIM: 604524; MGI: 106662; HomoloGene: 31085; GeneCards: LY75; OMA:LY75 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q24.2	Start	159,803,355 bp^[1]
Band	2q24.2	End	159,904,756 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 C1.1	Start	60,122,447 bp^[2]
Band	2\|2 C1.1	End	60,213,647 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

thymus

epithelium of nasopharynx

jejunal mucosa

bronchial epithelial cell

mucosa of paranasal sinus

nasal epithelium

skin of thigh

mucosa of sigmoid colon

lactiferous duct

pancreatic ductal cell

Top expressed in

granulocyte

thymus

primitive streak

yolk sac

lumbar spinal ganglion

jejunum

duodenum

tail of embryo

epiblast

blood

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding carbohydrate binding transmembrane signaling receptor activity signaling receptor activity
Cellular component	integral component of membrane integral component of plasma membrane extracellular exosome membrane
Biological process	inflammatory response endocytosis immune response signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4065


17076

Ensembl


ENSG00000054219


ENSMUSG00000026980

UniProt


O60449


Q60767

RefSeq (mRNA)


NM_002349


NM_013825

RefSeq (protein)


NP_001185688 NP_001185689


NP_038853

Location (UCSC)

Chr 2: 159.8 – 159.9 Mb

Chr 2: 60.12 – 60.21 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CD205 also called Lymphocyte antigen 75 is a protein that in humans is encoded by the LY75 gene.^[5]^[6]

CD205 is also known as DEC-205.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000054219 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026980 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kato M, Neil TK, Clark GJ, Morris CM, Sorg RV, Hart DN (Jun 1998). "cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells". Immunogenetics. 47 (6): 442–50. doi:10.1007/s002510050381. PMID 9553150. S2CID 10949216.
^ "Entrez Gene: LY75 lymphocyte antigen 75".

Tungekar MF, Gatter KC, Ritter MA (1996). "Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124)". Br. J. Cancer. 73 (4): 429–32. doi:10.1038/bjc.1996.77. PMC 2074450. PMID 8595155.
al-Tubuly AA, Luqmani YA, Shousha S, et al. (1996). "Differential expression of gp200-MR6 molecule in benign hyperplasia and down-regulation in invasive carcinoma of the breast". Br. J. Cancer. 74 (7): 1005–11. doi:10.1038/bjc.1996.481. PMC 2077117. PMID 8855966.
McKay PF, Imami N, Johns M, et al. (1999). "The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family". Eur. J. Immunol. 28 (12): 4071–83. doi:10.1002/(SICI)1521-4141(199812)28:12<4071::AID-IMMU4071>3.0.CO;2-O. PMID 9862343. S2CID 13656389.
Palmer DB, Crompton T, Marandi MB, et al. (1999). "Intrathymic function of the human cortical epithelial cell surface antigen gp200-MR6: single-chain antibodies to evolutionarily conserved determinants disrupt mouse thymus development". Immunology. 96 (2): 236–45. doi:10.1046/j.1365-2567.1999.00691.x. PMC 2326733. PMID 10233701.
Guo M, Gong S, Maric S, et al. (2000). "A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells". Hum. Immunol. 61 (8): 729–38. doi:10.1016/S0198-8859(00)00144-0. PMID 10980384.
Kato M, Neil TK, Fearnley DB, et al. (2000). "Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells". Int. Immunol. 12 (11): 1511–9. doi:10.1093/intimm/12.11.1511. PMID 11058570.
Kato M, Khan S, Gonzalez N, et al. (2003). "Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1". J. Biol. Chem. 278 (36): 34035–41. doi:10.1074/jbc.M303112200. PMID 12824192.
Bozzacco L, Trumpfheller C, Siegal FP, et al. (2007). "DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1289–94. Bibcode:2007PNAS..104.1289B. doi:10.1073/pnas.0610383104. PMC 1783096. PMID 17229838.
Nonaka D, Henley JD, Chiriboga L, Yee H (2007). "Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms". Am. J. Surg. Pathol. 31 (7): 1038–44. doi:10.1097/PAS.0b013e31802b4917. PMID 17592270. S2CID 30502411.