IRX4

Protein-coding gene in the species Homo sapiens
IRX4
Identifiers
AliasesIRX4, IRXA3, iroquois homeobox 4
External IDsOMIM: 606199; MGI: 1355275; HomoloGene: 9485; GeneCards: IRX4; OMA:IRX4 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for IRX4
Genomic location for IRX4
Band5p15.33Start1,877,413 bp[1]
End1,887,236 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for IRX4
Genomic location for IRX4
Band13|13 C1Start73,408,598 bp[2]
End73,417,727 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • apex of heart

  • skin of leg

  • hair follicle

  • gonad

  • left ventricle

  • minor salivary glands

  • vagina

  • right ventricle

  • epithelium of lactiferous gland
Top expressed in
  • lip

  • ventricle

  • atrioventricular canal

  • endocardial cushion

  • myocardium of ventricle

  • cardiac muscles

  • right ventricle

  • atrioventricular valve

  • primordial ventricle

  • upper lip
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • sequence-specific DNA binding
  • DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • heart development
  • regulation of transcription, DNA-templated
  • establishment of animal organ orientation
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50805

50916

Ensembl

ENSG00000113430

ENSMUSG00000021604

UniProt

P78413

Q9QY61

RefSeq (mRNA)

NM_016358
NM_001278632
NM_001278633
NM_001278634
NM_001278635

NM_018885

RefSeq (protein)

NP_001265561
NP_001265562
NP_001265563
NP_001265564
NP_057442

NP_061373

Location (UCSC)Chr 5: 1.88 – 1.89 MbChr 13: 73.41 – 73.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.[5][6]

Function

IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113430 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021604 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: iroquois homeobox 4".
  6. ^ Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi:10.1006/dbio.1999.9548. PMID 10625552.

Further reading

  • Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142. S2CID 37046813.
  • Wang GF, Nikovits W, Bao ZZ, Stockdale FE (2001). "Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression". J. Biol. Chem. 276 (31): 28835–41. doi:10.1074/jbc.M103716200. PMID 11382777.
  • Bayrak F, Kömürcü-Bayrak E, Mutlu B, et al. (2008). "Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy". Turk Kardiyol Dern Ars. 36 (2): 90–5. PMID 18497553.
  • Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests". European Journal of Human Genetics. 18 (7): 815–820. doi:10.1038/ejhg.2010.2. PMC 2987367. PMID 20125193.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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