LYL1

Protein-coding gene in the species Homo sapiens
LYL1
Identifiers
AliasesLYL1, bHLHa18, lymphoblastic leukemia associated hematopoiesis regulator 1, basic helix-loop-helix family member, LYL1 basic helix-loop-helix family member
External IDsOMIM: 151440; MGI: 96891; HomoloGene: 4078; GeneCards: LYL1; OMA:LYL1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for LYL1
Genomic location for LYL1
Band19p13.13Start13,099,033 bp[1]
End13,103,161 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for LYL1
Genomic location for LYL1
Band8 C3|8 41.02 cMStart85,428,078 bp[2]
End85,431,569 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • monocyte

  • trabecular bone

  • bone marrow

  • spleen

  • bone marrow cells

  • vena cava

  • superficial temporal artery

  • lymph node

  • appendix
Top expressed in
  • spleen

  • bone marrow

  • blood

  • interventricular septum

  • endocardial cushion

  • yolk sac

  • internal carotid artery

  • female urethra

  • subcutaneous adipose tissue

  • ankle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • protein binding
  • protein dimerization activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • positive regulation of transcription, DNA-templated
  • B cell differentiation
  • definitive hemopoiesis
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • blood vessel maturation
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4066

17095

Ensembl

ENSG00000104903

ENSMUSG00000034041

UniProt

P12980

P27792

RefSeq (mRNA)

NM_005583

NM_008535

RefSeq (protein)

NP_005574

NP_032561

Location (UCSC)Chr 19: 13.1 – 13.1 MbChr 8: 85.43 – 85.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.[5][6]

Interactions

LYL1 has been shown to interact with TCF3[7] and NFKB1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104903 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034041 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mellentin JD, Smith SD, Cleary ML (July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell. 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID 2752424. S2CID 24737263.
  6. ^ "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".
  7. ^ Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.
  8. ^ Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.

Further reading

  • Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proceedings of the National Academy of Sciences of the United States of America. 88 (24): 11416–20. Bibcode:1991PNAS...8811416X. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
  • Kuo SS, Mellentin JD, Copeland NG, Gilbert DJ, Jenkins NA, Cleary ML (June 1991). "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene". Oncogene. 6 (6): 961–8. PMID 2067848.
  • Saltman DL, Mellentin JD, Smith SD, Cleary ML (November 1990). "Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization". Genes, Chromosomes & Cancer. 2 (4): 259–65. doi:10.1002/gcc.2870020402. PMID 2268576. S2CID 103922.
  • Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". The EMBO Journal. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
  • Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A (January 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
  • Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.
  • Mahajan MA, Park ST, Sun XH (June 1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene. 12 (11): 2343–50. PMID 8649774.
  • Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.
  • Meng YS, Khoury H, Dick JE, Minden MD (November 2005). "Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia". Leukemia. 19 (11): 1941–7. doi:10.1038/sj.leu.2403836. PMID 16094422.

External links

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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