Protein-coding gene in the species Homo sapiens
NKX6-2 |
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Identifiers |
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Aliases | NKX6-2, GTX, NKX6.2, NKX6B, NK6 homeobox 2, SPAX8 |
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External IDs | OMIM: 605955; MGI: 1352738; HomoloGene: 18580; GeneCards: NKX6-2; OMA:NKX6-2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 10 (human)[1] |
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| Band | 10q26.3 | Start | 132,783,179 bp[1] |
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End | 132,786,147 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7 F4|7 84.57 cM | Start | 139,159,292 bp[2] |
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End | 139,162,713 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - substantia nigra
- putamen
- hippocampus proper
- temporal lobe
- amygdala
- hypothalamus
- caudate nucleus
- Brodmann area 9
- nucleus accumbens
- corpus callosum
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| Top expressed in | - ascending aorta
- aortic valve
- substantia nigra
- spermatid
- spermatocyte
- superior frontal gyrus
- supraoptic nucleus
- suprachiasmatic nucleus
- anterior horn of spinal cord
- facial motor nucleus
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - DNA-binding transcription factor activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- DNA binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | | Biological process | - multicellular organism development
- positive regulation of glial cell differentiation
- cell differentiation
- oligodendrocyte differentiation
- negative regulation of glial cell differentiation
- regulation of transcription, DNA-templated
- negative regulation of transcription by RNA polymerase II
- negative regulation of cell fate commitment
- neuromuscular process controlling balance
- positive regulation of cell fate commitment
- central nervous system myelination
- endocrine pancreas development
- regulation of myelination
- negative regulation of transcription, DNA-templated
- positive regulation of transcription by RNA polymerase II
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 10: 132.78 – 132.79 Mb | Chr 7: 139.16 – 139.16 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Homeobox protein Nkx-6.2 is a protein that in humans is encoded by the NKX6-2 gene.[5][6]
Nk6 homeobox 2 gene (Nkx6.2) is found on chromosome 10 in humans and on chromosome 7 in murine species.[7][8] Expression of the Nkx6.2 gene results in the Nkx6.2 transcription factor.[9] Its expression can be seen in the fetal brain, ventral portion of the neural tube, and the developing spinal cord during embryogenesis as well as in the adult brain.[9][10] Expression was also found to be in germ cells of testes.[11]
Nkx6.2 is involved in the patterning of the central nervous system during early embryo development.[12] As this gene continues to be researched, newfound information suggests that it aids in human oligodendrocyte maturation.[10][13] It has also been found to be important in motor function stemming from spinal neuronal circuits.[7]
Disorders with this gene can result in Spastic Ataxia which is a disease characterized by possible neurological issues, impaired learning ability, and a hypomyelinated central nervous system.[8][14] Another study has shown that methylation of Nkx6.2 can be correlated with renal cancer metastasis.[15] An Nkx6.2 knock-out mouse model showed abnormal motor ability thus corroborating that Nkx6.2 plays a role in central nervous system development.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000148826 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041309 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lee SH, Davison JA, Vidal SM, Belouchi A (February 2001). "Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors". Mamm. Genome. 12 (2): 157–62. doi:10.1007/s003350010247. PMID 11210186. S2CID 22368753.
- ^ "Entrez Gene: NK6 homeobox 2".
- ^ a b c Touch M, Harris A, Schakman O, Kondratskaya E, Boulland J, Dauguet N, Debrulle S, Baudouin C, Figueroa M, Mu X, Gow A, Glover C, Tissir F, Clotman F (2020). "Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits". Scientific Reports. 10 (1): 996. Bibcode:2020NatSR..10..996T. doi:10.1038/s41598-020-57945-4. PMC 6976625. PMID 31969659.
- ^ a b Hosseini Bereshneh A, Hosseipour S, Rasoulinezhad M, Pak N, Garshasbi M, Tavasoli A (2020). "Expanding the clinical and neuroimaging features of NKX6-2-related hereditary spastic ataxia type 8". European Journal of Medical Genetics. 63 (5): 103868. doi:10.1016/j.ejmg.2020.103868. PMID 32004679.
- ^ a b Vallstedt A, Muhr J, Pattyn A, Pierani A, Mendelsohn M, Sander M, Jessel T, Ericson J (2001). "Different Levels of Repressor Activity Assign Redundant and Specific Roles to Nkx6 Genes in Motor Neuron and Interneuron Specification". Neuron. 31 (5): 743–755. doi:10.1016/s0896-6273(01)00412-3. PMID 11567614.
- ^ a b Chelban V, Patel N, Vandrovcova J, Zanetti M, Lynch D, Ryten M, Botia J, Bello O, Tribollet E, Efthymiou S, Davagnanam I, Bashiri F, Wood N, Rothman J, Alkuraya F (2017). "Mutations in NKX6-2 Cause Progressive Spastic Ataxia and Hypomyelination". The American Journal of Human Genetics. 100 (6): 969–977. doi:10.1016/j.ajhg.2017.05.009. PMC 5473715. PMID 28575651.
- ^ Komuro I, Schalling M, Jahn L, Bodmer R, Jenkins N, Copeland N, Izumo S (1993). "Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter". The EMBO Journal. 12 (4): 1387–1401. doi:10.1002/j.1460-2075.1993.tb05783.x. PMC 413350. PMID 8096811.
- ^ Southwood C, He C, Garbern J, Kamholz J, Arroyo E, Gow A (2004). "CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure". Journal of Neuroscience. 24 (50): 11215–11225. doi:10.1523/JNEUROSCI.3479-04.2004. PMC 6730372. PMID 15601927.
- ^ Cai J, Zhu Q, Zheng K, Li H, Qi Y, Cao Q, Qiu M (2010). "Co-localization of Nkx6. 2 and Nkx2. 2 homeodomain proteins in differentiated myelinating oligodendrocytes". Glia. 58 (4): 458–468. doi:10.1002/glia.20937. PMC 2807475. PMID 19780200.
- ^ Shurrab S, Cordeiro D, Mercimek-Andrews S, Shuen AY (2023). "NKX6-2 Disease in Two Unrelated Patients with Early-Onset Spastic Quadriplegia and Diffuse Hypomyelinating Leukodystrophy". Brain Disorders. 9: 100069. doi:10.1016/j.dscb.2023.100069.
- ^ Serth J, Peters I, Katzendorn O, Dang T, Moog J, Balli Z, Reese C, Hennenlotter J, Grote A, Lafos M, Tezval H, Kuczyk M (2022). "Identification of a Novel Renal Metastasis Associated CpG-Based DNA Methylation Signature (RMAMS)". Int J Mol Sci. 23 (19): 11190. doi:10.3390/ijms231911190. PMC 9569431. PMID 36232491.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
(1) Basic domains |
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(1.1) Basic leucine zipper (bZIP) | |
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(1.2) Basic helix-loop-helix (bHLH) | Group A | |
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Group B | |
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Group C bHLH-PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3) bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2) Zinc finger DNA-binding domains |
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(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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see also transcription factor/coregulator deficiencies |
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