JARID2

JARID2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5HYN
Identifiers
Aliases	JARID2, JMJ, jumonji and AT-rich interaction domain containing 2
External IDs	OMIM: 601594 MGI: 104813 HomoloGene: 31279 GeneCards: JARID2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.3 Start 15,246,069 bp[1] End 15,522,042 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A5|13 21.66 cM Start 44,882,950 bp[2] End 45,075,119 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm trabecular bone nipple amniotic fluid Brodmann area 23 inferior olivary nucleus bone marrow middle temporal gyrus thymus Top expressed in internal carotid artery external carotid artery renal corpuscle secondary oocyte medullary collecting duct hair follicle blood conjunctival fornix corneal stroma trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding histone demethylase activity DNA-binding transcription repressor activity, RNA polymerase II-specific transcription factor binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific methylated histone binding histone H3-tri/di/monomethyl-lysine-4 demethylase activity Cellular component ESC/E(Z) complex nucleoplasm nucleus histone methyltransferase complex mitochondrion Biological process cell differentiation negative regulation of histone methylation regulation of transcription, DNA-templated thymus development negative regulation of transcription by RNA polymerase II spleen development transcription, DNA-templated stem cell differentiation multicellular organism development central nervous system development negative regulation of gene expression, epigenetic regulation of cell population proliferation liver development negative regulation of transcription, DNA-templated negative regulation of cell population proliferation positive regulation of histone H3-K9 methylation negative regulation of cardiac muscle hypertrophy cellular response to leukemia inhibitory factor negative regulation of cardiac muscle cell proliferation chromatin organization histone demethylation chromatin remodeling histone H3-K4 demethylation, trimethyl-H3-K4-specific Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3720 16468 Ensembl ENSG00000008083 ENSMUSG00000038518 UniProt Q92833 Q62315 RefSeq (mRNA) NM_001267040 NM_004973 NM_001205043 NM_001205044 NM_021878 NM_001360281 RefSeq (protein) NP_001253969 NP_004964 NP_001191972 NP_001191973 NP_068678 NP_001347210 Location (UCSC) Chr 6: 15.25 – 15.52 Mb Chr 13: 44.88 – 45.08 Mb PubMed search [3] [4]
Wikidata
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Protein Jumonji is a protein that in humans is encoded by the JARID2 gene.^[5][6] JARID2 is a member of the alpha-ketoglutarate-dependent hydroxylase superfamily.

Jarid2 (jumonji, AT rich interactive domain 2) is a protein coding gene that functions as a putative transcription factor. Distinguished as a nuclear protein necessary for mouse embryogenesis, Jarid2 is a member of the jumonji family that contains a DNA binding domain known as the AT-rich interaction domain (ARID).^{[7][8][9][10]} In vitro studies of Jarid2 reveal that ARID along with other functional domains are involved in DNA binding, nuclear localization, transcriptional repression,^[11] and recruitment of Polycomb-repressive complex 2 (PRC2).^[12][13] Intracellular mechanisms underlying these interactions remain largely unknown.

In search of developmentally important genes, Jarid2 has previously been identified by gene trap technology as an important factor necessary for organ development.^[7][11][14] During mouse organogenesis, Jarid2 is involved in the formation of the neural tube and development of the liver, spleen, thymus and cardiovascular system.^[15][16] Continuous Jarid2 expression in the tissues of the heart, highlight its presiding role in the development of both the embryonic and the adult heart.^[7] Mutant models of Jarid2 embryos show severe heart malformations, ventricular septal defects, noncompaction of the ventricular wall, and atrial enlargement.^[7] Homozygous mutants of Jarid2 are found to die soon after birth.^[7] Overexpression of the mouse Jarid2 gene has been reported to repress cardiomyocyte proliferation through it close interaction with retinoblastoma protein (Rb), a master cell cycle regulator.^[11][14][17] Retinoblastoma-binding protein-2 and the human SMCX protein share regions of homology between mice and humans.^[5]

References

Further reading

External links

• JARID2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.